Effects of physical exercise on plasma brain-derived neurotrophic factor in neurodegenerative disorders: A systematic review and meta-analysis of randomized controlled trials

Ruiz-González, David; Hernández‐Martínez, Alba; Valenzuela, Pedro L.; Morales, Javier S.; Soriano‐Maldonado, Alberto

doi:10.1016/j.neubiorev.2021.05.025

Cited by 84 publications

(83 citation statements)

References 49 publications

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“…Other limitations include short-term interventions (<26 weeks), low levels of disability of most participants (EDSS scores <4), and the inclusion of mainly relapsing-remitting MS or mixed-group patient populations and exclusion of patients with comorbidities that could their relief assessed due to exercise training. Moreover, we only included the intervention group of the included studies and analyzed the pre- and post-intervention levels of BDNF in PwMS who underwent exercise, as another meta-analysis conducted by Ruiz-González et al [ 89 ] compared post-intervention levels of BDNF in both PwMS and controls. It is worth emphasizing that Mackay et al [ 90 ] intended to assess the impact of aerobic exercise on BDNF levels in persons with neurological disorders without segregating neurologic conditions (e.g., MS).…”

Section: Discussionmentioning

confidence: 99%

Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials

et al. 2022

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Background Exercise training may affect the blood levels of brain-derived neurotrophic factor (BDNF), but meta-analyses have not yet been performed comparing pre- and post-intervention BDNF concentrations in patients with multiple sclerosis (PwMS). Objective To perform a meta-analysis to study the influence of exercise on BDNF levels and define components that modulate them across clinical trials of exercise training in adults living with multiple sclerosis (MS). Method Five databases (PubMed, EMBASE, Cochrane Library, PEDro database, CINAHL) were searched up to June 2021. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, we included 13 articles in the meta-analysis, including 271 subjects. To investigate sources of heterogeneity, subgroup analysis, meta-regression, and sensitivity analysis were conducted. We performed the meta-analysis to compare pre- and post-exercise peripheral levels of BDNF in PwMS. Results Post-exercise concentrations of serum BDNF were significantly higher than pre-intervention levels (Standardized Mean Difference (SMD): 0.33, 95% CI: [0.04; 0.61], p-value = 0.02). Meta-regression indicated that the quality of the included studies based on the PEDro assessment tool might be a source of heterogeneity, while no significant effect was found for chronological age and disease severity according to the expanded disability status scale. Conclusion This systematic review and meta-analysis shows that physical activity increases peripheral levels of BDNF in PwMS. More research on the effect of different modes of exercise on BDNF levels in PwMS is warranted.

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Section: Discussionmentioning

confidence: 99%

Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials

et al. 2022

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“…Neurological disorders are known to have an extremely negative impact on a person's quality of life and to be among the leading cause of disability and death globally [1][2][3]. In particular, those labelled as neurodegenerative diseases, i.e., characterized by progressive neuro losses, are seeing an increase in their prevalence and incidence in the global population [1,4].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, those labelled as neurodegenerative diseases, i.e., characterized by progressive neuro losses, are seeing an increase in their prevalence and incidence in the global population [1,4]. Alzheimer's disease, Parkinson's disease, multiple sclerosis, as well as other cognitive impairments, have a considerable impact on public health expenditure and, despite the efforts to establish new and effective pharmacological therapies, the current drug-based treatments still present limited advantages [2][3][4][5]. Therefore, physical exercise approaches have been proposed as promising strategies to support the treatment of such neurodegenerative disorders [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Statistical Analysis and Kinematic Assessment of Upper Limb Reaching Task in Parkinson’s Disease

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Ricciardi

Amato

et al. 2022

Sensors

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The impact of neurodegenerative disorders is twofold; they affect both quality of life and healthcare expenditure. In the case of Parkinson’s disease, several strategies have been attempted to support the pharmacological treatment with rehabilitation protocols aimed at restoring motor function. In this scenario, the study of upper limb control mechanisms is particularly relevant due to the complexity of the joints involved in the movement of the arm. For these reasons, it is difficult to define proper indicators of the rehabilitation outcome. In this work, we propose a methodology to analyze and extract an ensemble of kinematic parameters from signals acquired during a complex upper limb reaching task. The methodology is tested in both healthy subjects and Parkinson’s disease patients (N = 12), and a statistical analysis is carried out to establish the value of the extracted kinematic features in distinguishing between the two groups under study. The parameters with the greatest number of significances across the submovements are duration, mean velocity, maximum velocity, maximum acceleration, and smoothness. Results allowed the identification of a subset of significant kinematic parameters that could serve as a proof-of-concept for a future definition of potential indicators of the rehabilitation outcome in Parkinson’s disease.

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“…Interestingly, many studies provided viable evidence of miRNAs-mediated post-transcriptional regulation of BDNF ( Eyileten et al, 2017 , 2020 ). Several human studies and meta-analyses showed that physical exercise leads to elevation of blood BDNF levels ( Mrówczyński, 2019 ; Ruiz-González et al, 2021 ). Physical exercise induces BDNF secretion which leads to an increase of lactate levels in the blood, and elevation of CV response ( Schiffer et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Altered Circulating MicroRNA Profiles After Endurance Training: A Cohort Study of Ultramarathon Runners

et al. 2022

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BackgroundDespite the positive effects of endurance training on the cardiovascular (CV) system, excessive exercise induces not only physiological adaptations but also adverse changes in CV system, including the heart. We aimed to evaluate the selected miRNAs expression based on bioinformatic analysis and their changes before and after an ultramarathon run.Materials and MethodsCardiac tissue-specific targets were identified with the Tissue 2.0 database. Gene-gene interaction data were retrieved from the STRING app for Cytoscape. Twenty-three endurance athletes were recruited to the study. Athletes ran to completion (100 km) or exhaustion (52–91 km, median 74 km). All participants completed pre- and post-run testing. miRNAs expressions were measured both before and after the race.ResultsEnrichment analysis of the signaling pathways associated with the genes targeted by miRNAs selected for qRT-PCR validation (miR-1-3p, miR-126, miR-223, miR-125a-5p, miR-106a-5p, and miR-15a/b). All selected miRNAs showed overlap in regulation in pathways associated with cancer, IL-2 signaling, TGF-β signaling as well as BDNF signaling pathway. Analysis of metabolites revealed significant regulation of magnesium and guanosine triphosphate across analyzed miRNA targets. MiR-1-3p, miR-125a-5p, miR-126, and miR-223 expressions were measured in 23 experienced endurance athletes, before and after an ultramarathon wherein athletes ran to completion (100 km) or exhaustion (52–91 km, median 74 km). The expressions of miR-125a-5p, miR-126, and miR-223 were significantly increased after the race (p = 0.007, p = 0.001, p = 0.014, respectively). MiR-1-3p expression post-run showed a negative correlation with the post-run levels of high-sensitivity C-reactive protein (hs-CRP) (r = −0.632, p = 0.003). Higher miR-1-3p expression was found in runners, who finished the race under 10 h compared to runners who finished over 10 h (p = 0.001). Post-run miR-125a-5p expression showed a negative correlation with the peak lactate during the run (r = −0.576, p = 0.019).ConclusionExtreme physical activity, as exemplified by an ultramarathon, is associated with changes in circulating miRNAs’ expression related to inflammation, fibrosis, and cardiac muscle function. In particular, the negative correlations between miR-125a-5p and lactate concentrations, and miR-1-3p and hs-CRP, support their role in specific exercise-induced adaptation. Further studies are essential to validate the long-term effect of these observations.

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Effects of physical exercise on plasma brain-derived neurotrophic factor in neurodegenerative disorders: A systematic review and meta-analysis of randomized controlled trials

Cited by 84 publications

References 49 publications

Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials

Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials

Statistical Analysis and Kinematic Assessment of Upper Limb Reaching Task in Parkinson’s Disease

Altered Circulating MicroRNA Profiles After Endurance Training: A Cohort Study of Ultramarathon Runners

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