Effects of physical exercise on the cartilage of ovariectomized rats submitted to immobilization

Simas, José Martim Marques; Kunz, Regina Inês; Brancalhão, Rose Meire Costa; Ribeiro, Lucinéia de Fátima Chasko; Bertolini, Gladson Ricardo Flor

doi:10.1590/s1679-45082015ao3418

Cited by 7 publications

(10 citation statements)

References 32 publications

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“…As well, the application of appropriately timed biophysical stimuli when engineering neocartilage [7] , and one less well studied related topic, examining upstream factors that can be harnessed to protect articular cartilage may help to avert progressive cartilage deterioration and degradation, and/or to produce functional cartilage. As well, the possible use of multiple, rather than single therapeutic strategies to attenuate the disease process [15] , including joint protection efforts in the face of attempts to stimulate neocartilage might prove especially helpful, as might careful mechanical or electrical stimulation of the affected osteoarthritic joint or both [102][103][104][105][106][107][108][109][110][111][112] .…”

Section: Discussionmentioning

confidence: 99%

“…Highly promising too are the application of relevant magnetic stimuli that can affect calcium signaling and mechano transduction positively [1] , along with efforts to limit excess damage in those with diminished joint sensitivity, excess joint effusion, and unstable joints. Bio-imaging to monitor stem cell to chondrocyte differentiation processes [65] , the use of magnetic nanoparticles [48] , exercise [102][103][104] , and regenerative therapies that are carefully staged and of sufficient intensity and duration and tailored for each product may also help to foster maximal results [68] .…”

Section: Discussionmentioning

confidence: 99%

“…4. Efforts to examine and integrate promising physical modalities into the cartilage repair paradigm, such as laser light applications, ultrasound, pulsed electromagnetic fields, electrical stimulation, active and passive exercises [102][103][104][105][106][107][108][109][110][111][112][113][114][115] .…”

Section: Discussionmentioning

confidence: 99%

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Articular Cartilage Regeneration: An Update of Possible Treatment Approaches

Marks¹

2017

International Journal of Orthopaedics

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repair themes in the leading databases were examined. Specific emphasis was placed on a broad array of efforts and observations concerning articular cartilage and its repair. Articles of historic significance and more current strategies designed to foster cartilage repair were focused on, and reported in narrative form. Ideas extracted from the voluminous literature were those that answered one or more of the key questions driving this research. RESULTS: Numerous attempts have been made over time to foster cartilage repair, using a variety of approaches such as creating artificial cartilage, and transplanting stem cells into damaged cartilage to promote repair. Most current strategies are forged in laboratories and do not always account for the complex disease process, and the importance mechanical and inflammatory determinants play in the disease. However, manipulating biophysical, and biomechanical stimuli favorably is likely to hold promise for attenuating destruction of/or for fostering cartilage viability and repair, even in the presence of adverse osteoarthritic cartilage tissue changes. CONCLUSION: More work is needed to examine the key upstream determinants leading to articular cartilage destruction, and to enhancing the viability of the tissue. Employing carefully construed therapeutic strategies known to impact articular cartilage homeostasis safely and effectively can potentially preserve chondrocyte homeostasis, either alone or in conjunction with new technologies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Articular Cartilage Regeneration: An Update of Possible Treatment Approaches

Marks¹

2017

International Journal of Orthopaedics

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“…Vale salientar que o exercício físico intenso é utilizado como modelo para produção de osteoartrose 17 , denotando a importância que o exercício seja dosado adequadamente, como em estudo anterior apontando para efeitos benéficos sobre a cartilagem do exercício de subida em escada para ratas submetidas à ooforectomia e imobilização de membros pélvicos 18 .…”

Section: Figuraunclassified

Diferentes Respostas Do Tecido Ósseo E Articular De Ratos Wistar, Submetidos a Exercício Resistido, Após Lesão Nervosa

Baretta¹,

Pelissari²,

Escher³

et al. 2017

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RESUMO | Objetivo:analisar o efeito do exercício resistido de subida em escadas nos tecidos ósseo e articular, após lesão compressiva do nervo isquiático de ratos Wistar. Material e Métodos: 32 ratos foram divididos aleatoriamente em 4 grupos, com 8 animais em cada, G1 (controle), G2 (exercício), G3 (lesão) e G4 (lesão e exercício). Após a lesão nervosa G2 e G4 foram submetidos ao exercício resistido de subida em escada, durante 5 dias na semana, com intervalo de 2 dias, por 21 dias. Os animais foram eutanasiados e as articulações do joelho e tíbias do membro pélvico lesionado foram coletadas, e seguiram o processamento padrão para análises em microscopia de luz. Resultados: O tecido ósseo apresentou alterações significativas, em relação a análise morfométrica da área do canal medular e contagem e osteócitos, porém, não foi observada diferença significativa em relação a análise da espessura do osso cortical. Na cartilagem articular do joelho foram observadas discretas alterações morfológicas entre os grupos, como a presença de clones celulares no grupo G3 e remodelagem no grupo G4. Conclusão: a lesão do nervo isquiático em ratos Wistar trouxe efeitos deletérios ao tecido ósseo e articular. Também foi observado que o exercício físico resistido em subida de escada não trouxe alterações ao tecido ósseo dos animais, porém, foi eficaz ao retorno às características normais da cartilagem articular lesionada, e demonstrou aumento da evidencia da tidemark, em animais não lesionados. ABSTRACT | Objective:To analyze the effect of resistance exercise climb stairs in bone tissue and articular after compression injury of the sciatic nerve of Wistar rats. Methods: 32 rats were randomly divided into 4 groups with 8 animals in each, G1 (control), G2 (exercise), G3 (injury) and G4 (injury and exercise). After nerve injury G2 and G4 were submitted to resistance exercise climb stairs, for 5 days a week, with two days interval for 21 days. After the experiment, the animals were euthanized and the knee and tibia of the injured hindlimb were collected, and followed the standard processing for analysis by light microscopy. Results: The bone tissue change significantly in relation to morphometric analysis of the area of the spinal canal and counting and osteocytes, however, was not observed significant difference in the analysis of the thickness of the cortical bone. A joint tissue were observed discrete morphological changes between the groups. Conclusion: The sciatic nerve injury in rats brought deleterious effects on bone tissue and articular. It was also observed that resistance exercise in stair climbing brought no changes to bone tissue of animals, however, it was effective to return to the normal characteristics of the injured joint, and showed increased evidence of tidemark in uninjured animals.

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“…The clinical manifestation of osteoporosis in women correlates with the menopausal period, a female physiological condition characterized by a decrease in the production of estrogen and progesterone, substantial hormones of skeletal maintenance 6 . In these circumstances, the bone resorption process becomes more pronounced than the one of synthesis, generating a structural imbalance, an important factor in the characterization of the disease 7,8 . There is an expected that 50% of women after 50 years of age will suffer from a fracture caused by low bone mineral density, with vertebral injuries being more frequent 9 .…”

Section: Introductionmentioning

confidence: 99%

Effects of oophorectomy on the lumbar spine of Wistar rats submitted to vibratory platform treatment

Tavares¹,

A²,

Kakihata³

et al. 2020

Arch Med Deporte

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Introduction: This study evaluated the effect of the vibratory platform on the lumbar spine morphology of Wistar rats submitted to hormonal deprivation by oophorectomy. Material and method: Twenty rats were divided into four groups: Pseudo-oophorectomy (GP), Pseudo-oophorectomy Treated (GPT), Oophorectomy (GO), Oophorectomy Treated (GOT). After 60 days of postoperative, the treated groups started exercises on a vibratory platform in the frequency parameters of 60 Hz, alternating vibration with amplitude of 2 mm, acceleration of 57.6 m/s² and time of 10 minutes, three times in the during the four week period. Following the euthanasia of the animals, the lumbar spine was dissected and processed for analysis of the anterior and posterior longitudinal ligaments, intervertebral disc height (IVD), nucleus pulposus (NP) height, radiographic density of the lumbar vertebrae and IVD morphology. Results: The results showed a decrease in the height of the NP associated to the GO and morphological alterations such as lamellar disorganization and presence of rifts in the fibrous ring, alterations of the structural limits and decrease of the NP cavity; while the other groups presented organized lamellae, peripheral and nuclear region well delimited and wide cavity of the nucleus. Conclusion: In this way, it can be concluded that the oophorectomy protocol promoted a decrease in the height of the NP of the IVD and that the exercise in the vibratory platform did not generate lesions in the analyzed tissues, as well as preserved the structural organization of the IVD and the height of the NP of oophorectomized rats.

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Effects of physical exercise on the cartilage of ovariectomized rats submitted to immobilization

Cited by 7 publications

References 32 publications

Articular Cartilage Regeneration: An Update of Possible Treatment Approaches

Articular Cartilage Regeneration: An Update of Possible Treatment Approaches

Diferentes Respostas Do Tecido Ósseo E Articular De Ratos Wistar, Submetidos a Exercício Resistido, Após Lesão Nervosa

Effects of oophorectomy on the lumbar spine of Wistar rats submitted to vibratory platform treatment

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