Effects of physical endurance training on the plasma renin-angiotensin-aldosterone system in normal man

Abstract

The effect of physical endurance training on the plasma renin-angiotensin-aldosterone system was studied in 27 normal sedentary volunteers aged between 20 and 55 years, using a randomized two-period cross-over study design. After 4 months of training (2.5 h/week), peak oxygen uptake and physical working capacity at a heart rate of 130 beats/min were increased by 16% (P less than 0.01) and 29% (P less than 0.001) respectively, whereas resting heart rate was decreased by 15% (P less than 0.001). The plasma noradrenaline concentration and haematocrit were both decreased (P less than 0.01) after training. For the total group of subjects, the small decreases in plasma renin activity (PRA) and in the plasma concentrations of angiotensin-I, angiotensin-II and aldosterone were not statistically significant. However, the change in PRA during the training period was negatively correlated with the increase in physical working capacity (r = -0.49, P less than 0.01), suggesting that PRA decreased only in those subjects with the greatest increase in exercise capacity. Also, the change in plasma aldosterone during training was negatively related to the rise in physical working capacity (r = -0.57, P less than 0.01). Furthermore, the changes in plasma angiotensin-I (r = 0.75), angiotensin-II (r = 0.49) and aldosterone (r = 0.43) during the training period correlated positively with the change in PRA. It is concluded that physical endurance training, leading to a substantial gain of physical working capacity, suppresses the plasma renin-angiotensin-aldosterone system in normal man.

Effect of aerobic exercise training on blood pressure sensitivity to dietary sodium in older hypertensives

“…The reduction in plasma aldosterone concentration following the aerobic exercise training programme may be owing to an adaptation of the adrenal gland to adrenocorticotrophin stimulation. 23 It has been shown that adrenocorticotrophin-induced release Values are means7standard deviation.…”

Nongenomic Steroid Action: Controversies, Questions, and Answers

“…However, physical training, which leads to a substantial gain in working capacity, does not affect aldosterone levels at rest or at exercise (175). A possible explanation is the suppression of the renin-angiotensin-aldosterone system (RAAS) secondary to training to counteract stress-induced activation (211). The action on baroreflex mentioned above and the reducing effect on heart rate variability (271) may point to an adrenergic-like action of aldosterone.…”

Influência do treinamento aeróbio nos mecanismos fisiopatológicos da hipertensão arterial sistêmica

“…Segundo o autor, esse efeito está associado a reduções da ativação simpática, concentrações plasmáticas de angiotensina II e vasopressina. Outros estudos também relatam redução dos níveis de renina e angiotensina II após o treinamento em indivíduos normotensos (HESPEL et al, 1988). Entretanto, em indivíduos hipertensos os estudos ainda não são conclusivos.…”