Effects of Physical Agents on Muscle Healing with a Focus on Animal Model Research

Sakamoto, Miki

doi:10.1298/ptr.r0011

Cited by 5 publications

(3 citation statements)

References 55 publications

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“…Observations also suggest that the absorption of mechanical energy may modify gene expression, growth factors, and collagens. Together, thermal and non-thermal effects on the target tissue have been proposed to result in increased local metabolism, circulation, extensibility of connective tissue, and tissue regeneration [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Mechanical Vibration in Equine Osteoarthritis: A Pilot Study

Rinnovati,

Meistro,

Ralletti

et al. 2024

Applied Sciences

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The use of therapeutic ultrasounds (TUs) is widespread in both human and veterinary medicine. In fact, mechanical vibration is the simplest and purest form of vibratory energy that is applied either in physical therapies or in rehabilitation medicine. In particular, the use of low-frequency TUs to treat equine conditions is a new and evolving field. In the equine industry, osteoarthritis (OA) is one of the most challenging causes of lameness. Despite its prevalence and the advancements in its treatment, there is still no therapy whose results are completely decisive. Little is described in the literature about the use of TUs in horses’ joints, particularly regarding its use to treat OA. For these reasons, the aim of this study was to preliminarily assess the efficacy of low-frequency ultrasound in two horses with metacarpo/metatarso-phalangeal joint OA. The reduction in lameness was significant in both treated cases, pointing to the effective therapeutic action of TUs. However, to better evaluate the long-term effects in athlete horses, it is necessary to include in the research a greater number of cases and a control group.

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Section: Introductionmentioning

confidence: 99%

Effects of Mechanical Vibration in Equine Osteoarthritis: A Pilot Study

Rinnovati,

Meistro,

Ralletti

et al. 2024

Applied Sciences

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“…Observations also suggest that the absorption of mechanical energy may modify gene expression, growth factors, and collagens [ 4 ]. Together, thermal and non-thermal effects on the target tissue have been proposed to result in increased local metabolism, circulation, extensibility of connective tissue, and tissue regeneration [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Complementary and Alternative Veterinary Medicine in Sport and Companion Animals: Therapeutic Ultrasound

Boström

Asplund

Bergh

et al. 2022

Animals

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Background: To explore the scientific evidence for therapeutic ultrasound (TU), we conducted a systematic review of the literature on TU in dogs, horses, donkeys, and cats. Methods: In three major databases, relevant articles published in 1980–2020 were identified. The risk of bias in each article was evaluated. Results: Twenty-four relevant articles on the effects of TU in dogs, nine in horses, two in donkeys, and one in cats were identified. TU usually involved 2–6 treatments weekly for up to 4 weeks. Articles on tendon, ligament, and bone healing, acute aseptic arthritis, osteoarthritis, paraparesis, hindquarter weakness, and back muscle pain were identified. In experimental bone lesions in dogs, there is moderate scientific evidence for enhanced healing. For the treatment of other musculoskeletal conditions, the scientific evidence is insufficient due to the high risk of bias. There is substantial evidence that continuous TU increases tissue temperature in muscles and tendons by up to 5 °C in healthy animals. For disorders in tendons, ligaments, muscles, and joints in sport and companion animals, there is insufficient evidence for the clinical effects of TU.

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“…In particular, when it is complicated with a fracture or neurovascular injury, SMI is often ignored or placed in a secondary position ( Yan, 2018 ); incomplete repair after SMI, for chronic inflammation and scar, often leads to sequelae (limb pain, incomplete functional recovery, etc. ), which has become the main problem and challenge in clinics ( Chiu et al, 2020 ; Sakamoto, 2021 ; Yamamoto et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Research on skeletal muscle impact injury using a new rat model from a bioimpact machine

Liao

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Introduction: Skeletal muscle impact injury occurs frequently during sports, falls, and road traffic accidents. From the reported studies on skeletal muscle injury, it is difficult to determine the injury parameters. Therefore, we developed a new model of gastrocnemius impact injury in rats with a bioimpact machine, with which the experimental operation could be conducted in feasibility from the recorded parameters. Through this novel model, we study the skeletal muscle impact injury mechanisms by combining temporal and spatial variation.Methods: The gastrocnemius of anesthetized rats was injured by a small pneumatic-driven bioimpact machine; the moving speed and impact force were determined, and the whole impact process was captured by a high-speed camera. We observed the general condition of rats and measured the changes in injured calf circumference, evaluating calf injuries using MRI, gait analysis system, and pathology at different times after the injury.Results: The gastrocnemius was injured at an impact speed of 6.63 m/s ± 0.25 m/s and a peak force of 1,556.80 N ± 110.79 N. The gait analysis system showed that the footprint area of the RH limb decreased significantly on the first day and then increased. The calf circumference of the injured limb increased rapidly on the first day post-injury and then decreased in the next few days. MRI showed edema of subcutaneous and gastrocnemius on the first day, and the area of edema decreased over the following days. HE staining showed edema of cells, extensive hyperemia of blood vessels, and infiltration of inflammatory cells on the first day. Cell edema was alleviated day by day, but inflammatory cell infiltration was the most on the third day. TEM showed that the sarcoplasmic reticulum was dilated on the first day, the mitochondrial vacuolation was obvious on the second day, and the glycogen deposition was prominent on the fifth day.Conclusion: In our experiment, we developed a new and effective experimental animal model that was feasible to operate; the injured area of the gastrocnemius began to show “map-like” changes in the light microscope on the third day. Meanwhile, the gastrocnemius showed a trend of “edema-mitochondrial vacuolation-inflammatory cell aggregation” after impact injury.

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Effects of Physical Agents on Muscle Healing with a Focus on Animal Model Research

Cited by 5 publications

References 55 publications

Effects of Mechanical Vibration in Equine Osteoarthritis: A Pilot Study

Effects of Mechanical Vibration in Equine Osteoarthritis: A Pilot Study

Systematic Review of Complementary and Alternative Veterinary Medicine in Sport and Companion Animals: Therapeutic Ultrasound

Research on skeletal muscle impact injury using a new rat model from a bioimpact machine

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