Effects of Perioperative Acetyl Salicylic Acid on Clinical Outcomes in Patients Undergoing Craniotomy for Brain Tumor

The Effect of Preoperative Antiplatelet Therapy on Hemorrhagic Complications after Decompressive Craniectomy in Patients with Traumatic Brain Injury

“…Hemorrhagic complications of neurosurgical procedures are sometimes disastrous, which is why most neurosurgeons recommended that all antiplatelet agents should be discontinued before surgery 15). In 1994, Palmer et al13) reported that the perioperative administration of ASA in intracranial surgery was the most commonly associated risk factor for postoperative hemorrhagic complications requiring additional surgery for hematoma evacuation.…”

“…The authors suggested that spine surgery could be done without stopping antiplatelet therapy 1). In 2015, Rahman et al15) investigated 83 patients with brain tumor on chronic ASA therapy. Fifty five patients had discontinued ASA before surgery and 28 patients continued ASA during the perioperative period 15).…”

“…In 2015, Rahman et al15) investigated 83 patients with brain tumor on chronic ASA therapy. Fifty five patients had discontinued ASA before surgery and 28 patients continued ASA during the perioperative period 15). There were no statistical differences between the groups in outcomes, including bleeding complications, need for reoperation, or thrombotic complications in this retrospective cohort analysis 15).…”

“…The number of patients taking antiplatelet agents is increasing because antiplatelet therapy has been shown to have a clear advantage in secondary prevention of cardiovascular events and a possible benefit in primary prevention as well 15). However, in 1994, it was reported that preoperative use of antiplatelet agents was the most commonly associated risk factor for postoperative hematomas requiring surgical evacuation after neurosurgery 13).…”

Surgical Hemostasis in the Era of Anticoagulation: Guidelines and Recommendations Summary

“…In regard to neurosurgical, intimately invasive procedures, the risk prior to the fi fth post-op day appears signifi cant [ 35 ]. Conversely, Ahmed et al found no signifi cant differences in hemorrhagic or thrombotic complications in craniotomy patients who either stopped aspirin perioperatively or continued to take it up to and through the operation [ 36 ]. Another study found no increase in the risk of hemorrhage in transsphenoidal operations for sellar and parasellar lesions [ 37 ].…”