Effects of periodontal treatment on primary sjȫgren’s syndrome symptoms

Ambrósio, Luciana; Rovai, Emanuel Silva; França, Bruno Nunes de; Balzarini, Danilo; Abreu, Ieda Santos; Lopes, Sheyla Batista Bologna; Nunes, Thaís Borguezan; Lourenço, Sílvia Vanessa; Pasoto, Sandra Gofinet; Saraiva, Luciana; Holzhausen, Marinella

doi:10.1590/1807-3107bor-2017.vol31.0008

Cited by 18 publications

(19 citation statements)

References 34 publications

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“…The pSS patients in our study had severer ocular expressions and signs of dry eye and reported severer anxiety and depression. Furthermore, studies show that pSS patients have a decreased salivary flow with high risk of dental caries, enhanced susceptibility to oral candidiasis, tooth loss, severer periodontal destruction, pain during chewing, pararthria, tongue palpitation and angular cheilitis [ 36 – 38 ]. Anxious pSS individuals, because of their avoidant behaviours, often have poorer dental health.…”

Section: Discussionmentioning

confidence: 99%

Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study

Cui

Xia

et al. 2018

BMC Psychiatry

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BackgroundPrevalence of anxiety and depression is high in people with Primary Sjögren’s syndrome (pSS). However, there are currently no known reported studies about anxiety/depression in pSS patients from China. Our aim was to compare anxiety/depression in pSS patients and healthy controls; to investigate the prevalence of anxiety and/or depression among pSS patients in China; to evaluate its relationship with the disease activity, fatigue, pain, education, ocular surface disease, oral health, swallowing disorders, employment status, European League Against Rheumatism Sjögren’s Syndrome Patient Reported Index(ESSPRI) as well as to analyze potential determinants of anxiety and depression.MethodsIn this study, 160 pSS patients and 170 age- and sex- matched healthy controls were included. Participants completed self-administered questionnaires, Hospital Anxiety and Depression Scale (HADS) and so on. Independent samples t-tests, χ2 analyses and multivariable stepwise logistic regression modeling were used to analyze the data.ResultsWe found 33.8% pSS patients were anxiety, and 36.9% had depression, which were significantly higher than controls. And there were significant correlations among education, employment status, disease activity, fatigue, ocular surface disease, ESSPRI, oral health, swallowing disorders and anxiety/depression. Meanwhile, logistic regression analysis revealed that oral health and swallowing disorders were significantly associated with anxiety in pSS patients; as well as fatigue was significantly associated with depression.ConclusionsThe prevalence of depression and anxiety was high in adult pSS patients. Interestingly, oral health and swallowing disorders were the most important predictors of anxiety in pSS patients. Therefore, rheumatologists should pay attention to the potential mental comorbidities while managing patients with pSS and provide the basis for mental health providers in order to identify effective strategies for preventing and treating depression and anxiety among adult pSS patients. Simultaneously, rheumatologists should also focus on the oral health and swallowing disorders in pSS patients.

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Section: Discussionmentioning

confidence: 99%

Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study

Cui

Xia

et al. 2018

BMC Psychiatry

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“…Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease mainly characterized by involvement of the exocrine glands, leading to dry mouth or sicca syndrome with a global prevalence of about 0.04% to 4.8%, and mostly affecting women between the fourth and fifth decades of life . Even though sicca symptoms are the most frequent features of the disease, the inflammatory process can extend to several other organs and tissues and constitutional symptoms, including fatigue, and widespread pain, may impair quality of life .…”

Section: Introductionmentioning

confidence: 99%

Prevalence, correlates, and impact of sleep disturbance in Chinese patients with primary Sjögren’s syndrome

Cui

et al. 2019

Int J of Rheum Dis

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Aim Sleep disturbances are common in primary Sjögren's syndrome (pSS) patients and may lead to disease aggravation and decreased health‐related quality of life (HRQoL). There are currently no known reported studies related to the prevalence, correlates, and impact of sleep disturbance in pSS patients from China. Therefore, this study aims to assess the sleep quality in Chinese pSS patients and evaluate its relationship with the disease activity, quality of life and mood disorders. Methods A self‐report survey was administered to 221 pSS patients and 198 healthy individuals using the Pittsburgh Sleep Quality Index (PSQI) for sleep quality. Disease activity and damage were evaluated with the European League Against Rheumatism Sjögren's syndrome disease activity index (ESSDAI). Independent samples t tests, Chi‐square analysis, logistic regression were used to analyze these data. Results Our results found that the prevalence of poor sleep (PSQI ≥ 6) was 57.5% and the mean global score of PSQI was 6.57 (SD 3.19) in patients, which were significantly higher than the controls (32.3% and 4.93 [SD 2.86], respectively). When trying to fall asleep, patients with pSS had some sleep disturbances, reduced sleep efficiency, increased number of awakenings than controls. There were significant correlations among dryness, ocular surface disease, HRQoL, pain, disease activity, anxiety/depression and sleep quality in pSS patients. Meanwhile, logistic regression models identified depression and Short Form‐36 mental composite score as predictors of poor sleep quality. Conclusions Sleep disturbances are commonly reported in pSS patients and sleep quality is lower in pSS patients than in healthy controls. The data suggested the need for holistic assessment and management of pSS patients.

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“…In patients with SS, destruction of the salivary glands results in dry mouth and bacterial overgrowth and is followed by PD. Periodontal treatment in patients with SS may increase salivary flow and improve clinical and immunological parameters and quality of life [34]. Furthermore, alterations of cytokine network may play important roles in the link between PD and SS.…”

Section: Discussionmentioning

confidence: 99%

Association between Periodontal Disease and Subsequent Sjögren’s Syndrome: A Nationwide Population-Based Cohort Study

Lin

Tseng

Liu

et al. 2019

IJERPH

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Xerostomia (dry mouth) is the cardinal symptom of Sjögren’s syndrome (SS), which is an autoimmune disease involving the exocrine glands and other organs. Xerostomia may predispose patients to periodontal disease (PD) and an association between SS and PD has been reported. This association may be bidirectional; therefore, we conducted this study to investigate the risk of SS in patients with PD using data from the National Health Insurance Research Database of Taiwan. A total of 135,190 patients were enrolled in our analysis. In all, 27,041 patients with PD were matched by gender, age, insured region, urbanization and income, with cases and controls in a 1:4 ratio. Both groups were followed and the risks of SS were calculated by Cox proportional hazards regression. Finally, 3292 (2.4%) patients had newly diagnosed SS. Patients with PD had a significantly higher risk of subsequent SS (903 (3.3%) vs. 2389 (2.2%), adjusted hazard 1.47, 95% confidence interval: 1.36–1.59). In conclusion, patients with PD had an approximately 50% increased risk of subsequent SS. Physicians should be aware of the symptoms and signs of SS in patients with PD.

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Effects of periodontal treatment on primary sjȫgren’s syndrome symptoms

Cited by 18 publications

References 34 publications

Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study

Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study

Prevalence, correlates, and impact of sleep disturbance in Chinese patients with primary Sjögren’s syndrome

Association between Periodontal Disease and Subsequent Sjögren’s Syndrome: A Nationwide Population-Based Cohort Study

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