Effects of PCBs and PBDEs on thyroid hormone, lymphocyte proliferation, hematology and kidney injury markers in residents of an e-waste dismantling area in Zhejiang, China

Xu, Pingwei; Lou, Xiaoming; Ding, Gang; Shen, Haitao; Wu, Lizhi; Chen, Zhijian; Han, Jiaguang; Wang, Xiaofeng

doi:10.1016/j.scitotenv.2015.07.025

Cited by 64 publications

(41 citation statements)

References 43 publications

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“…Serious problems occurred in China due to relatively primitive technologies used to process the e-waste. Dangerous levels of polychlorinated biphenyls and polybrominated diphenyl ethers have been observed in various environmental matrices, such as the atmosphere, sediment, water and soil, and in biological samples, including human serum, cord blood, breast milk, placenta and hair from many Chinese e-waste dismantling sites [3].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Specific Conditions on Cu, Ni, Zn and Al Recovery from PCBS Waste Using Acidophilic Bacterial Strains

Mražíková¹,

Kaduková²,

Marcinčáková³

et al. 2016

Archives of Metallurgy and Materials

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The objective of this work was to evaluate the influence of static, stirring and shaking conditions on copper, zinc, nickel and aluminium dissolution from printed circuit boards (PCBs) using the mixed acidophilic bacterial culture of Acidithiobacillus ferrooxidans and Acidithiobacillus thiooxidans. The results revealed that static conditions were the most effective in zinc and aluminium dissolution. Zinc was removed almost completely under static conditions, whereas maximum of nickel dissolution was reached under the stirring conditions. The highest copper recovery (36%) was reached under stirring conditions. The shaking conditions appeared to be the least suitable. The relative importance of these systems for the bioleaching of copper and nickel decreased in the order: stirring, static conditions, shaking.

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Section: Introductionmentioning

confidence: 99%

The Effect of Specific Conditions on Cu, Ni, Zn and Al Recovery from PCBS Waste Using Acidophilic Bacterial Strains

Mražíková¹,

Kaduková²,

Marcinčáková³

et al. 2016

Archives of Metallurgy and Materials

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“…Human with prenatal or postnatal exposure to PBDEs has been demonstrated to be associated with several adverse health outcomes (Chao et al, 2014b;Hsu et al, 2014) including low birth length and weight (Chao et al, 2007), menstrual irregularity , disruption of thyroid and growth hormones (Shy et al, 2012), and interference with neurological development in infants (Chao et al, 2011). In the recent study in the e-waste dismantling areas, the researchers found that serum levels of PBDEs were related with increasing levels of white blood cells, hemoglobin, and platelets (Xu et al, 2015a).…”

Section: Introductionmentioning

confidence: 99%

Levels of Polybrominated Diphenyl Ethers in Air-Conditioner Filter Dust Used to Assess Health Risks in Clinic and Electronic Plant Employees

Chou

Kao

Chuang

et al. 2016

Aerosol Air Qual. Res.

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Because consumer products release them, polybrominated diphenyl ethers (PBDEs) are frequently present in a variety of indoor environments including homes and workplaces. Our goal was to investigate PBDEs contamination of workplace air-conditioner filter dust to assess the health effects of contaminated dust on workers with occupational exposure. Nine medical clinics, four dental clinics, eight factory offices, and six factory clean rooms were selected in southern Taiwan between April 2013 and September 2014. Air-conditioner-filter dust was collected by a high-efficiency vacuum cleaner and then PBDEs were analyzed by a high-resolution gas chromatography coupled with high-resolution mass spectrometry.

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“…Previous epidemiological and experimental data on some individual chemicals could have led to predict decreased thyroid hormone availability. For instance, high PCB or BDE exposure depresses circulating thyroid hormone levels in humans and different species3233. However, many of these experiments were based on long term exposure where increased clearance is subsequent to transient interactions with distributor proteins.…”

Section: Discussionmentioning

confidence: 99%

Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos

Fini¹,

Mughal²,

Mevel³

et al. 2017

Sci Rep

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Thyroid hormones are essential for normal brain development in vertebrates. In humans, abnormal maternal thyroid hormone levels during early pregnancy are associated with decreased offspring IQ and modified brain structure. As numerous environmental chemicals disrupt thyroid hormone signalling, we questioned whether exposure to ubiquitous chemicals affects thyroid hormone responses during early neurogenesis. We established a mixture of 15 common chemicals at concentrations reported in human amniotic fluid. An in vivo larval reporter (GFP) assay served to determine integrated thyroid hormone transcriptional responses. Dose-dependent effects of short-term (72 h) exposure to single chemicals and the mixture were found. qPCR on dissected brains showed significant changes in thyroid hormone-related genes including receptors, deiodinases and neural differentiation markers. Further, exposure to mixture also modified neural proliferation as well as neuron and oligodendrocyte size. Finally, exposed tadpoles showed behavioural responses with dose-dependent reductions in mobility. In conclusion, exposure to a mixture of ubiquitous chemicals at concentrations found in human amniotic fluid affect thyroid hormone-dependent transcription, gene expression, brain development and behaviour in early embryogenesis. As thyroid hormone signalling is strongly conserved across vertebrates the results suggest that ubiquitous chemical mixtures could be exerting adverse effects on foetal human brain development.

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Effects of PCBs and PBDEs on thyroid hormone, lymphocyte proliferation, hematology and kidney injury markers in residents of an e-waste dismantling area in Zhejiang, China

Cited by 64 publications

References 43 publications

The Effect of Specific Conditions on Cu, Ni, Zn and Al Recovery from PCBS Waste Using Acidophilic Bacterial Strains

The Effect of Specific Conditions on Cu, Ni, Zn and Al Recovery from PCBS Waste Using Acidophilic Bacterial Strains

Levels of Polybrominated Diphenyl Ethers in Air-Conditioner Filter Dust Used to Assess Health Risks in Clinic and Electronic Plant Employees

Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos

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