Effects of Pasteurella haemolytica A1 leukotoxin on bovine neutrophils: degranulation and generation of oxygen-derived free radicals

Maheswaran, S. K.; Weiss, Douglas J.; Kannan, Mathur; Townsend, Elise L.; Reddy, Kanamata; Whiteley, Laurence O.; Srikumaran, Subramaniam

doi:10.1016/0165-2427(92)90034-n

Cited by 55 publications

(55 citation statements)

References 25 publications

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“…However, activation of bovine neutrophils by M. haemolytica leads in bulk to elevation of intracellular calcium [139], oxidative burst [114] and production of several lipid mediators [30,69] and proinflammatory cytokines [193] (Tab. I).…”

Section: Apoptosis/necrosismentioning

confidence: 99%

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How Mannheimia haemolytica defeats host defence through a kiss of death mechanism

2005

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-Mannheimia haemolytica induced pneumonias are only observed in goats, sheep and cattle. The bacterium produces several virulence factors,whose principal ones are lipopolysaccharide and leukotoxin. The latter is cytotoxic only for ruminant leukocytes, a phenomenon that is correlated with its ability to bind and interact with the ruminant β2-integrin Lymphocyte Function-associated Antigen 1. This paper globally reviews all the information available on host-pathogen interactions underlying respiratory mannheimiosis (formerly pasteurellosis), from the stable and the Petri dish to the biochemical cascade of events triggered by the leukotoxin inside ruminant leukocytes. One conclusion can be made: the most widespread cattle respiratory disease with the most important impact on beef production worldwide, is probably due to a tiny ruminant-specific focal variation in the CD18-and/or CD11a-expressing genes.

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Section: Apoptosis/necrosismentioning

confidence: 99%

“…Oxygen-derived free radicals are also generated following LKT stimulation (Fig. 3) [114]. At the molecular level, they could act as second messengers and activate several factors and genes involved in the immune response and in apoptosis [35].…”

Section: Death Pathwaysmentioning

confidence: 99%

How Mannheimia haemolytica defeats host defence through a kiss of death mechanism

2005

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“…Neutrophils are phagocytic granulocytes responsible for rapid migration to infection foci and pathogen clearance there as well as important roles in cell-cell communication and tissue remodelling. In fact, neutrophils may be responsible for excessive inflammation and tissue damage observed in the BRDC associated with transportation-stressed cattle (Maheswaran et al, 1992;Lekeux, 1995;Wessely-Szponder et al, 2004). A profound leukocytosis, marked by neutrophilia may occur in conjunction with a decrease in the number of lymphocytes (Blecha et al, 1984;Preisler et al, 2000), indicating a disruption of neutrophil homoeostasis in response to stress in cattle.…”

Section: Haematological Cell Changes Indicative Of a Stress Responsementioning

confidence: 99%

“…This bacterial toxin stimulated respiratory burst and degranulation is reported to cause the cytolysis of neutrophils (Maheswaran et al, 1992). It is possible that the proteolytic enzymes and reactive oxygen species released into surrounding lung tissue may cause more severe damage than the leukotoxin itself, exacerbating an already dangerous pathological state.…”

Section: The Neutrophil Paradox and Bovine Respiratory Disease Complexmentioning

confidence: 99%

“…It is also probable that other mechanisms such as a delay in apoptosis and an overwhelming of neutrophil-clearing macrophages play roles in neutrophil-mediated tissue damage associated with the BRDC. Although many reports have investigated neutrophil function during natural and experimental cases of the BRDC (Maheswaran et al, 1992;Coomber et al, 2001;WesselySzponder et al, 2004), there are limited studies that have explored neutrophil function during transportation of cattle (Murata et al, 1987). Thus, decreased apoptosis of neutrophils in combination with increased migratory capacity in dairy cows after 4 h of transportation, support a potential enhancement of the pro-inflammatory response.…”

Section: The Neutrophil Paradox and Bovine Respiratory Disease Complexmentioning

confidence: 99%

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Invited review: Relationship between cattle transport, immunity and respiratory disease

Earley

Sporer

Gupta

2017

Animal

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The association between transportation and the occurrence of the bovine respiratory disease complex (BRDC) has long been recognised. Many hypotheses regarding this association have been declared through the past decades, and it is agreed upon by most researchers that the multiple stressors that calves experience during transportation result in an overall immunosuppression that allows the respiratory tract to be invaded by numerous opportunistic pathogens. Furthermore, the innate immune cells, neutrophils, may be trapped in a paradox whereby their crucial defence and pathogen-killing activities are counteracted by excessive inflammation and tissue damage that may exacerbate disease, including the BRDC. Neutrophilia in response to glucocorticoids has been attributed to an influx of immature neutrophils newly released from the bone marrow, a decrease in neutrophil margination along endothelial walls, and a decrease in neutrophil apoptosis. Several of these explanations have been confirmed by altered expression of genes and proteins important for neutrophil margination and apoptosis.

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Construction of an isogenic leukotoxin deletion mutant ofPasteurella haemolyticaserotype 1: characterization and virulence

Tatum

Briggs

Sreevatsan

et al. 1998

Microbial Pathogenesis

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Effects of Pasteurella haemolytica A1 leukotoxin on bovine neutrophils: degranulation and generation of oxygen-derived free radicals

Cited by 55 publications

References 25 publications

How Mannheimia haemolytica defeats host defence through a kiss of death mechanism

How Mannheimia haemolytica defeats host defence through a kiss of death mechanism

Invited review: Relationship between cattle transport, immunity and respiratory disease

Construction of an isogenic leukotoxin deletion mutant ofPasteurella haemolyticaserotype 1: characterization and virulence

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