Effects of Parecoxib, a Parenteral COX-2-specific Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Propofol

Abstract

Single-bolus parecoxib, in doses to be used perioperatively, does not alter the disposition or the magnitude or time course of clinical effects of bolus propofol. Effects on a propofol infusion were not evaluated.

Augmentation of Myocardial Production of 15-Epi-Lipoxin-A 4 by Pioglitazone and Atorvastatin in the Rat

“…However, valdecoxib may suppress P-450 2C9 (CYP2C9). 30 On the other hand, it has been reported that P-450 induced by aspirin generates both 15-R-HETE (40%, which is converted to 15-epi-LXA 4 ) and 15-S-HETE (60%, which is converted to lipoxin-A 4 ). 26 Indeed, it was demonstrated that aspirin augmented the generation of both lipoxins and 15-epi-lipoxins in human lung adenocarcinoma cell line.…”

Valdecoxib: the rise and fall of a COX-2 inhibitor

“…Drug interactions between valdecoxib and many other drugs have been extensively studied [35,36]. Of particular interest is the fact that valdecoxib does not significantly affect the action of methotrexate.…”

Analytical Procedure for Determination of Cyclooxygenase-2 Inhibitors in Biological Fluids by High Performance Liquid Chromatography: A Review

“…This drug has been approved for the treatment of rheumatoid arthritis, osteoarthritis and pain [113][114][115]. Valdecoxib is metabolized primarily by cytochrome P450 2C9 and 3A4 to the pharmacological active hydroxylated metabolite and the carboxylic acid metabolite in humans [116][117][118]. Chemical structures of valdecoxib, hydroxylated valdecoxib, and carboxylic acid valdecoxib are shown in Fig.…”