Effects of orexin-monoaminergic interactions on oxytocin secretion in rat neurohypophyseal cell cultures

Ocskó, Tímea; Gálfi, Márta; Radács, Marianna; Molnár, Zsolt; Kis, Gyongyi; Rákosi, Kinga; Molnár, Árpád; László, Ferenc; Varga, Csaba

doi:10.1016/j.regpep.2012.01.002

Cited by 8 publications

(5 citation statements)

References 64 publications

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“…Moreover, orexin‐A inhibited the activities of PVN OT neurons by inhibiting glutamatergic excitatory synaptic input (Maejima et al, 2017). A previous study also revealed the inhibitory effect of orexin on OT, showing that the changes in OT secretion induced by the monoaminergic system can be directly impacted by the orexin system (Ocsko et al, 2012). However, how the five OXTR SNPs in this study affect OXTR function and the orexin system remains unclear.…”

Section: Discussionmentioning

confidence: 80%

Genotype–genotype interactions of the OXTR gene polymorphisms are associated with self‐reported daytime dysfunction, sleep latency and personal distress

Wang

Guan

et al. 2022

Journal of Sleep Research

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The oxytocin receptors located in the corticotropin-releasing factor neurons of the paraventricular nucleus are stimulated by oxytocin. Oxytocin functions as the regulator of the corticotropin-releasing factor system and in turn promotes sleep quality. The objective of this study was to examine the main and genotypegenotype interactive effects of the oxytocin receptor gene (OXTR) polymorphisms on sleep quality. A total of 324 participants were randomly recruited from a university in Beijing, China. Sleep quality was measured with the Pittsburgh Sleep Quality Index. The OXTR single-nucleotide polymorphisms (rs2254298, rs2268498, rs13316193, rs2268490 and rs2268491) were genotyped. The results showed that gender and age were associated with various empathy traits (all p < 0.001). The Pittsburgh Sleep Quality Index was positively correlated with the Personal Distress subscale of empathy (p < 0.001). Both rs2254298 and rs2268491 interacted with rs13316193 to influence daytime dysfunction and Personal Distress (all p < 0.05), indicating that in individuals with rs13316193 CC/CT genotype, those with rs2254298 AA/AG or rs2268491 TT/TC genotypes displayed higher daytime dysfunction and Personal Distress scores than those with rs2254298 GG or rs2268491 CC genotypes.Conversely, among the individuals with rs2254298 GG or rs2268491 CC genotypes, the rs13316193 C allele carriers had lower daytime dysfunction and Personal Distress scores than rs13316193 TT homozygotes. There was also a significant interaction between rs2268490 and rs2268498 on the sleep latency dimension of the Pittsburgh Sleep Quality Index. Our findings reveal for the first time the genotype-genotype interactions of the OXTR gene on sleep quality, which may open new research avenues for studying psychopathology involving sleep problems.

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Section: Discussionmentioning

confidence: 80%

Genotype–genotype interactions of the OXTR gene polymorphisms are associated with self‐reported daytime dysfunction, sleep latency and personal distress

Wang

Guan

et al. 2022

Journal of Sleep Research

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“…Second, during labor and delivery, oxytocin and catecholamine level increases. As shown in vitro studies of cultured cells, oxytocin, 11,24–26 dopamine 27 epinephrine, and norepinephrine 28,29 increase the expression of orexin‐A. As a result, orexin‐A level in NVD is higher than C/S.…”

Section: Discussionmentioning

confidence: 87%

The influence of mode of delivery, anthropometric indices, and infant's sex on the maternal and cord blood orexin‐A levels: A cohort study

Razavinia

Tehranian

Sadatmahalleh

et al. 2021

J of Obstet and Gynaecol

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Background Orexin as an adipokin hormone plays an important role in appetite regulation, energy metabolism, obesity, diabetes, and cardiovascular disease. The main source of orexin secretion in nonpregnant and pregnant women is adipose tissue and placenta, respectively. This research was conducted to evaluate the association between orexin‐A level and the mode of delivery, anthropometric indices, and sex of the infant. Methods This prospective cohort study was conducted on 69 normal pregnant women. The samples of umbilical cord blood were obtained at the time of delivery, and maternal blood was taken within 24 h of delivery. Serum orexin‐A levels were measured by using enzyme‐linked immunosorbent assay. Statistical analyses were performed using SPSS and p < 0.05 was considered as significant. Results We found a significant difference between postpartum maternal and umbilical cord orexin‐A level both with the mode of delivery (p < 0.001). Also, a significant positive correlation was seen between maternal and umbilical cord serum orexin‐A levels (r = −0.61, p < 0.001). There was no relationship between serum orexin‐A levels with anthropometric indices and the sex of the neonate (p > 0.05). Conclusion Both maternal and umbilical cord serum orexin‐A levels were associated with the mode of delivery. Maternal and cord blood orexin‐A levels in normal vaginal delivery are higher than cesarean section.

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“…Both mice with NC and patients with NC are prone to develop metabolic disorders, such as obesity (Sakurai, ), which may increase the risk of pregnancy complications. Recently, a link between HCRT peptides and hypothalamic oxytocin secretion has been suggested based on data in vitro (Ocskò et al ., ), and expression of HCRT peptides and receptors has been reported in the uterus (Nietkiewicz et al ., ; Silveyra et al ., ). These findings raise the hypothesis that lack of HCRT peptides directly or indirectly compromises uterine contraction.…”

Section: Discussionmentioning

confidence: 99%

A critical role of hypocretin deficiency in pregnancy

Bastianini

Berteotti

Martire

et al. 2013

Journal of Sleep Research

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Summary Hypocretin/orexin peptides are known for their role in the control of the wake–sleep cycle and narcolepsy–cataplexy pathophysiology. Recent studies suggested that hypocretin peptides also have a role in pregnancy. We tested this hypothesis by conducting a retrospective analysis on pregnancy complications in two different mouse models of hypocretin deficiency. We recorded 85 pregnancies of mice lacking either hypocretin peptides (knockout) or hypocretin‐releasing neurons (transgenic) and their wild‐type controls. Pregnancy was associated with unexplained dam death before delivery in 3/15 pregnancies in knockout mice, and in 3/23 pregnancies in transgenic mice. No casualties occurred in wild‐type pregnant dams (P < 0.007 versus hypocretin‐deficient mice as a whole). Hypocretin deficiency did not impact either on litter size or the number of weaned pups per litter. These data provide preliminary evidence of a critical role of hypocretin deficiency in pregnancy.

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Effects of orexin-monoaminergic interactions on oxytocin secretion in rat neurohypophyseal cell cultures

Cited by 8 publications

References 64 publications

Genotype–genotype interactions of the OXTR gene polymorphisms are associated with self‐reported daytime dysfunction, sleep latency and personal distress

Genotype–genotype interactions of the OXTR gene polymorphisms are associated with self‐reported daytime dysfunction, sleep latency and personal distress

The influence of mode of delivery, anthropometric indices, and infant's sex on the maternal and cord blood orexin‐A levels: A cohort study

A critical role of hypocretin deficiency in pregnancy

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