Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients

Fumeron, Christine; Nguyen–Khoa, Thao; Saltiel, C.; Kebede, Messeret; Buisson, Claude; Drüeke, Tilman B.; Lacour, Bernard; Massy, Ziad A.

doi:10.1093/ndt/gfh928

Cited by 88 publications

(82 citation statements)

References 24 publications

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“…iron treatment (48). In contrast to our results with juice, antioxidant supplements such as the N-3 fatty acid docosahexaenoic acid or vitamins C and E were not found to decrease the protein carbonyl content in hemodialysis patients (10,11). Further juice intervention studies in hemodialysis patients utilizing the protein carbonyl content as biomarker have not been described yet.…”

Section: Cancer Epidemiology Biomarkers and Prevention Cancer Epidemiocontrasting

confidence: 99%

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Anthocyanin/Polyphenolic–Rich Fruit Juice Reduces Oxidative Cell Damage in an Intervention Study with Patients on Hemodialysis

Spormann¹,

Albert

Rath

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Hemodialysis patients face an elevated risk of cancer, arteriosclerosis, and other diseases, ascribed in part to increased oxidative stress. Red fruit juice with high anthocyanin/polyphenol content had been shown to reduce oxidative damage in healthy probands. To test its preventive potential in hemodialysis patients, 21 subjects in a pilot intervention study consumed 200 mL/day of red fruit juice (3-week run-in; 4-week juice uptake; 3-week wash-out). Weekly blood sampling was done to monitor DNA damage (comet assay F formamidopyrimidine-DNA glycosylase enzyme), glutathione, malondialdehyde, protein carbonyls, trolox equivalent antioxidant capacity, triglycerides, and DNA binding capacity of the transcription factor nuclear factor-KB. Results show a significant decrease of DNA oxidation damage (P < 0.0001), protein and lipid peroxidation (P < 0.0001 and P < 0.001, respectively), and nuclear factor-KB binding activity (P < 0.01), and an increase of glutathione level and status (both P < 0.0001) during juice uptake. We attribute this reduction in oxidative (cell) damage in hemodialysis patients to the especially high anthocyanin/polyphenol content of the juice. This provides promising perspectives into the prevention of chronic diseases such as cancer and cardiovascular disease in population subgroups exposed to enhanced oxidative stress like hemodialysis patients. (Cancer Epidemiol Biomarkers Prev 2008; 17(12):3372 -80)

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Section: Cancer Epidemiology Biomarkers and Prevention Cancer Epidemiocontrasting

confidence: 99%

“…Blood sampling was done after each experimental week (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Samples were drawn immediately before the beginning of the dialysis session, 1 to 2 h after juice ingestion.…”

Section: Methodsmentioning

confidence: 99%

Anthocyanin/Polyphenolic–Rich Fruit Juice Reduces Oxidative Cell Damage in an Intervention Study with Patients on Hemodialysis

Spormann¹,

Albert

Rath

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In accordance, C3f fragments have been found in the sera of patients with myocardial infarction but not in healthy controls (186). Although several polypeptides were affected/normalized by short-term oral vitamin C supplementation, the authors were not able to find any significant difference between classic oxidative/antioxidative stress and inflammation markers under vitamin C supplementation (187). Taken together, proteome analysis of plasma, urine, and dialysis fluid by proteomic analysis represents a sensitive and valuable new tool to pinpoint new molecular changes associated with uremia.…”

Section: Proteomics-a New Era Of Research In Ckdmentioning

confidence: 82%

Emerging Biomarkers for Evaluating Cardiovascular Risk in the Chronic Kidney Disease Patient

Stenvinkel¹,

Carrero²,

Axelsson³

et al. 2008

Clinical Journal of the American Society of Nephrology

487

373

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Premature cardiovascular disease (CVD), including stroke, peripheral vascular disease, sudden death, coronary artery disease, and congestive heart failure, is a notorious problem in patients with chronic kidney disease (CKD). Because the presence of CVD is independently associated with kidney function decline, it appears that the relationship between CKD and CVD is reciprocal or bidirectional, and that it is this association that leads to the vicious circle contributing to premature death. As randomized, placebo-controlled trials have so far been disappointing and unable to show a survival benefit of various treatment strategies, such a lipid-lowering, increased dialysis dose and normalization of hemoglobin, the risk factor profile seems to be different in CKD compared with the general population. Indeed, seemingly paradoxical associations between traditional risk factors and cardiovascular outcome in patients with advanced CKD have complicated our efforts to identify the real cardiovascular culprits. This review focuses on the many new pieces that need to be fit into the complicated puzzle of uremic vascular disease, including persistent inflammation, endothelial dysfunction, oxidative stress, and vascular ossification. Each of these is not only highly prevalent in CKD but also more strongly linked to CVD in these patients than in the general population. However, a causal relationship between these new markers and CVD in CKD patients remains to be established. Finally, two novel disciplines, proteomics and epigenetics, will be discussed, because these tools may be helpful in the understanding of the discussed vascular risk factors.

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“…200 mg/d [18], 800 IU/d [19] and 1,200 IU/d [20]). With regard to vitamin C, three studies found statistically significant treatment effects [21][22][23], and two found no treatment effect [28,29]. Firm conclusions are difficult to draw from these studies due to the wide variation in doses used and the differing lengths of each intervention.…”

Section: Discussionmentioning

confidence: 99%

“…As for ADMA, therapies that lower CRP as a marker of inflammation may therefore be expected to reduce CVD risk. A number of studies have suggested that antioxidant supplementation may lower CRP [18][19][20][21][22][23], but this is not always consistent [24][25][26][27][28][29][30]. Similarly, increasing levels of tHcy in cell cultures seems to promote IL-6 production by monocytes [31] and endothelial cells [32] and, therefore, B vitamins may also reduce CRP as a result of their tHcy-lowering potential.…”

Section: Introductionmentioning

confidence: 99%

Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial

et al. 2010

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Woodside, J. (2010). Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and Creactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial. European Journal of Nutrition, 49(8) AbstractPurpose Cardiovascular risk factors such as elevated levels of asymmetric dimethylarginine (ADMA)/C-reactive protein (CRP) and homocysteine are potentially related to essential micronutrients such as certain B vitamins and antioxidant vitamins. The aim of the present study was to investigate whether supplementation with moderate doses of B vitamins and/or antioxidants could alter either ADMA and/or CRP concentrations in middle-aged, apparently healthy men with mildly elevated homocysteine levels. Methods A randomised, double-blind, factorial design, intervention study was carried out on 132 men with mildly elevated homocysteine levels, allocated to four groups (a) B vitamins alone-1 mg folic acid, 7.2 mg pyridoxine, 0.02 mg cyanocobalamin daily, (b) antioxidants alone-150 mg ascorbic acid, 67 mg vitamin E, 9 mg b-carotene daily, (c) B vitamins with antioxidant vitamins, or (d) placebo. A total of 101 men completed the study to 8 weeks.Results When the percentage of baseline ADMA and CRP was examined at 8 weeks, no statistically significant differences were observed between the four groups (p = 0.21 and p = 0.90, respectively). Similar non-significant results were observed when analysis was stratified based on baseline CRP levels (\1.0 mg/L, p = 0.10; C1.0 mg/L, p = 0.64) and smoking status (all p C 0.05). Conclusions Supplementation with moderate doses of B vitamins and/or antioxidants did not alter either ADMA or CRP concentrations in these middle-aged, apparently healthy men with mildly elevated homocysteine levels.

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Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients

Abstract: Short-term oral vitamin C supplementation did not modify well-defined oxidative/antioxidative stress and inflammation markers in HD patients. Whether a higher oral dose or the intravenous route can modify these markers remains to be determined.

Cited by 88 publications

References 24 publications

Anthocyanin/Polyphenolic–Rich Fruit Juice Reduces Oxidative Cell Damage in an Intervention Study with Patients on Hemodialysis

Anthocyanin/Polyphenolic–Rich Fruit Juice Reduces Oxidative Cell Damage in an Intervention Study with Patients on Hemodialysis

Emerging Biomarkers for Evaluating Cardiovascular Risk in the Chronic Kidney Disease Patient

Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial

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