Effects of Oral Supplementation of L-Arginine in the Treatment of Pulmonary Hypertension Secondary to Pulmonary Embolism: A Case Report

Ogata, Hiroshi; Takahashi, Tomoko; Ishikawa, Kazunobu; Ishibashi, Tosiyuki; Maruyama, Yukio; Watanabe, Machiko; Edo, Kiyoto

doi:10.5387/fms.56.135

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…On the other hand, a reduction in NO availability of vascular endothelium occurs under the conditions of diabetes and inflammation, resulting in compromised vascular activity. A supplement of L-arginine is beneficial to vasorelaxation favorable to relieve the abnormal vascular activity [37]. In the testing for suppression on inflammation caused by carrageenin, however, L-arginine, as a NO donor, which was neutral while medicated alone, no improvement, or worsen of the inflamed edema, was found (unpublished data).…”

Section: Discussionmentioning

confidence: 90%

ER Stress, P66shc, and P-Akt/Akt Mediate Adjuvant-Induced Inflammation, Which Is Blunted by Argirein, a Supermolecule and Rhein in Rats

et al. 2011

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We investigated the anti-inflammatory activities of argirein and rhein on inflammatory edema in rat paw which was caused by complete adjuvant, compared with ibuprofen. We hypothesized that the adjuvant-induced inflammation is attributed to upregulation of activating transcript factor 6 (ATF6; a chaperone for endoplasmic reticulum (ER) stress), p66Shc (an adaptive protein modulating oxidative stress), and NADPH oxidase subunits p22phox and gp91phox in the inflamed tissues. Biomarkers were measured in the rat paw in association with monitoring swellings. The primary inflammatory edema of the injected paw occurred rapidly and sustained over a couple of days, and the secondary inflammation developed 2 weeks later. The inflammatory edema was accompanied by upregulation of cytokines including ATF6, p66Shc, p22phox, gp91phox, and MMP-2 and an increase in ratio of p-Akt/Akt in the afflicted paw. These were suppressed by either argirein and rhein or ibuprofen. These findings indicate that ER stress, upregulated p66Shc, and phosphorylated Akt are actively implicated in the inflammatory zone caused by adjuvant injection. These biomarkers were causal factors responsible for inflammation of the afflicted paw and were suppressed by a supermolecule argirein and rhein, and the anti-inflammatory activities of the two compounds were comparable to that of ibuprofen.

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Section: Discussionmentioning

confidence: 90%

ER Stress, P66shc, and P-Akt/Akt Mediate Adjuvant-Induced Inflammation, Which Is Blunted by Argirein, a Supermolecule and Rhein in Rats

et al. 2011

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“…In the present study, oral arginine administration did not significantly increase exhaled NO concentration in healthy subjects. However, the reports on the effectiveness of arginine for patients with pulmonary hypertension 6,7,25) , suggest that the production of NO by arginine administration in the airways and the pulmonary artery may be enhanced in patients with pulmonary hypertension. It is necessary to examine whether oral arginine increases exhaled NO in patients with pulmonary hypertension in the future.…”

mentioning

confidence: 99%

“…L -arginine (arginine) is a substrate for NOS to produce NO in vivo 5) . We previously reported a case of pulmonary hypertension, in which arginine administration was therapeutically effective 6) . As for the mechanism, there is a possibility that NO production in the pulmonary artery was enhanced by administration of arginine, and the produced NO relaxed the pulmonary artery 7) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Oral L-Arginine Administration on Exhaled Nitric Oxide (No) Concentration in Healthy Volunteers

Ogata

Yatabe

Misaka

et al. 2013

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: We previously reported a case of pulmonary hypertension, where the symptoms were improved by oral L -arginine (arginine) administration. Arginine may increase nitric oxide (NO) production in the pulmonary artery. Exhaled NO may reflect pulmonary artery NO production. It has been demonstrated that exhaled NO concentration is higher in patients with allergic diseases, but whether oral arginine administration alters exhaled NO is unknown. Therefore, in this study, we investigated whether oral arginine administration increases exhaled NO among healthy volunteers with and without a history of allergy. Eleven subjects were given a single oral dose (200 mg/kg) of arginine, and their plasma arginine concentrations and exhaled NO were measured up to 150 minutes. Baseline values of exhaled NO concentration were significantly higher in those with a history of allergy (56.4±20.3 ppb, n=5, P<0.05) than those without (16.8±4.0 ppb, n=6). Oral arginine increased exhaled NO, which peaked at 60 minutes after the administration in those with a history of allergy (85.2±44.8 ppb, n=5). However, the increase in exhaled NO was not significant compared to the baseline values. In contrast, plasma arginine concentration was increased significantly by arginine administration (P<0.01), regardless of an allergy history. These results suggested that the difference in exhaled NO concentration was not due to a difference in arginine absorption. Serum IgE level was significantly higher in the group with a history of allergy. Eosinophils and white blood cells were within normal range in all subjects. We conclude that oral arginine administration does not significantly increase exhaled NO, regardless of allergy history. However, as arginine administration has been reported to be effective in patients with pulmonary hypertension, it will be necessary to test exhaled NO in subjects with pulmonary hypertension in the future.

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Effects of Oral Supplementation of L-Arginine in the Treatment of Pulmonary Hypertension Secondary to Pulmonary Embolism: A Case Report

Cited by 2 publications

References 14 publications

ER Stress, P66shc, and P-Akt/Akt Mediate Adjuvant-Induced Inflammation, Which Is Blunted by Argirein, a Supermolecule and Rhein in Rats

ER Stress, P66shc, and P-Akt/Akt Mediate Adjuvant-Induced Inflammation, Which Is Blunted by Argirein, a Supermolecule and Rhein in Rats

Effect of Oral L-Arginine Administration on Exhaled Nitric Oxide (No) Concentration in Healthy Volunteers

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