Effects of Oral Cromolyn on the Nasal Response due to Foods

Protective Effects of Oral Disodium Cromoglycate on the Asthmatic Responses Induced by Food Allergy

“…The five types of asthmatic response induced by food ingestion challenge in bronchial asthma patients, described in this as well as in our previous papers [7,19,[23][24][25]84], may be comparable with the basic types of the asthmatic response to the bronchial challenge with inhalant allergens [76][77][78][79].…”

“…confirmation of a patient 's eligibility for the study and the exclusion of contraindications [4,[6][7][8]10,11,19,20,[23][24][25]39,41,45,[47][48][49][51][52][53][54][55][56][57][58]60,61,63,64]. This procedure consisted of: (1) the general part: disease history, physical examination, basic laboratory tests, X-ray of chest and sinuses, lung function, determination of blood gases and bacteriological examination of the sputum; (2) the allergologic part: skin tests with inhalant and food allergens, bronchial histamine threshold [61,[75][76][77][78][79], and determination of the serum immunoglobulins; (3) 109 bronchial challenges with inhalant allergens (BPT) [75][76][77][78][79] and (4) 97 ingestion challenges with selected foods, suspected from the history and/or skin tests, in combination with recording of the lung function (FVC and FEV 1 ). A 7-day interval was always inserted between the consecutive tests, to prevent carry-over effects.…”

“…The skin prick tests (SPTs) in concentration of 500 BU/mL were performed and evaluated after 20 minutes and again after 24 hours. If the SPT were negative, than intracutaneous (intradermal) tests in concentrations of 100 BU/mL and 500 BU/mL were carried out and evaluated 20 minutes, 6, 12, 24, 36, 48, 72 and 96 hours after the injection [6,7,19,20,[23][24][25]40,43,61,[76][77][78][79][80]. If the SPTs were positive (early/immediate skin response), then the intracutaneous tests were performed in concentrations of 200 BU/mL and evaluated up to 96 hours after the injection.…”

“…Histamine diphosphate was used as a positive, whereas PBS as a negative control. A skin wheal (>7.0 mm in diameter) appearing within 20 minutes after the injection was considered to be a positive immediate skin response, the skin infiltration observed between 6-12 hours to be a late skin response and the skin in duration than recorded 48 hours orlater to was designated a delayed skin response [6,7,19,20,[23][24][25]40,43,61,[76][77][78][79][80].…”

Late Type of Bronchial Response to Milk Ingestion Challenge: A Comparison of Open and Double-Blind Challenge

“…In addition, it is eligible in cases where the objective parameters can be recorded. This technique is not suitable for challenges where the results can be influenced by the patient or by the investigator or where the response can only be measured by means of subjective parameters, such as headache, (skin) itching, tiredness, and behavior changes [ 1 – 3 , 6 – 11 , 16 , 22 , 27 , 42 , 45 , 48 , 49 , 52 , 73 ].…”