Effects of Oral Administration of Water Extract of Nigella sativa on
Serum Concentrations of Insulin and Testosterone in Alloxan-induced Diabetic
Rats

Mansi, Kamal

doi:10.3923/pjbs.2005.1152.1156

Cited by 21 publications

(2 citation statements)

References 12 publications

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“…Improvement in serum insulin and decline in blood glucose levels in Nigella sativa treated groups could be explained by the effect of Nigella sativa itself. Where Nigella sativa could cause partial regeneration and proliferation of pancreatic β-cells leading to increase in insulin secretion (Mansi, 2005). Thus indicating the insulinotropic properties of Nigella sativa oil (Fararh et al, 2002) which helps in glucose utilization by cells in glycolysis, tricarboxylic acid cycle, hexose monophosphate shunt and glycogenesis pathways (Krishnamurthy et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Biochemical Efficacy of <i>Nigella Sativa Oil</i> and Metformin on Induced Diabetic Male Rats

Mahmoud¹,

Saleh²,

Ghannam³

et al. 2014

American Journal of Animal and Veterinary Sciences

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This study was carried out to investigate possible beneficial effects of Nigella sativa oil supplementation to diabetic rats. Fifty male Sprague-Dawley rats were randomly divided into five groups (n= 10/group) as follows: Group I (normal control), group II (diabetic control), group III (diabetic rats treated with metformin), group IV (diabetic rats treated with metformin and Nigella sativa oil) and group V (diabetic rats treated with Nigella sativa oil). Insulin, testosterone, male gametogenic hormones, insulin resistance, serum lipid profile, testicular redox state, relative weight of testes, tail of epididymis, accessory sex glands (prostate and seminal gland), epididymal sperm count, alive sperm percent and abnormalities percent were estimated. Results revealed improvement in the studied parameters within group III, IV and V compared with non treated diabetic group with better improvement in group IV. Conclusion: Co-administration of metformin and Nigella sativa oil could result in better regulation of diabetes and diabetes induced subfertility in male rats due to hypoglycemic, hypolipidemic and antioxidant properties of Nigella sativa.

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Section: Discussionmentioning

confidence: 99%

Biochemical Efficacy of <i>Nigella Sativa Oil</i> and Metformin on Induced Diabetic Male Rats

Mahmoud¹,

Saleh²,

Ghannam³

et al. 2014

American Journal of Animal and Veterinary Sciences

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“…Recently, some studies have evaluated the effects of medicinal herbs such as NS on some risk factors for NAFLD such as insulin resistance, hyperlipidemia, oxidative stress and inflammation in experimental models (41)(42)(43)(44). In this study, we sought to review the results of these studies and find the future direction in this field of science.…”

Section: Contextmentioning

confidence: 99%

Nigella sativa and Non-Alcoholic Fatty Liver Disease: A Review of the Current Evidence

2018

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Context: Nigella sativa (NS) has been used as an herbal remedy for the treatment and prevention of a variety of diseases. In this review, we aimed to summarize the current evidence on the effects of NS consumption on non-alcoholic fatty liver disease (NAFLD) characteristics. Evidence Acquisition: We reviewed the existing literature published by the end of 2017 using the following key words: "Nigella sativa", "black seeds", "black cumin", "thymoquinone", "NAFLD", "NASH", and "diabetes". Papers used in this study were collected by searching the PubMed, Google Scholar, Science Direct and Scopus databases. Our search was limited to English-language articles. All the articles published between 2000 and 2017 meeting the inclusion criteria were included in the study. Results: The results of current studies indicate that NS has many biological effects such as anti-inflammatory, anti-hyperlipidemic, anti-microbial, anti-cancer, anti-oxidative, anti-diabetic, anti-hypertensive and wound healing activities. In summary, it can be used as a valuable plant for designing therapeutic strategies in NAFLD. Conclusions: Results from available studies indicate that NS can ameliorate the main metabolic disturbances related to NAFLD including hyperglycemia, hyperlipidemia, and overweight. These effects are mainly attributed to the anti-oxidative and antiinflammatory properties of thymoquinone. Clinical trials on human subjects are highly essential to confirm the results found in in vivo and in vitro studies.

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Nutritional Features and Bioactivities of Thymoquinone against Type 2 Diabetes Mellitus

Atukeren

2023

Natural Products and Their Bioactives in Antidiabetic Drug Discovery

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Effects of Oral Administration of Water Extract of Nigella sativa on Serum Concentrations of Insulin and Testosterone in Alloxan-induced Diabetic Rats

Cited by 21 publications

References 12 publications

Biochemical Efficacy of <i>Nigella Sativa Oil</i> and Metformin on Induced Diabetic Male Rats

Biochemical Efficacy of <i>Nigella Sativa Oil</i> and Metformin on Induced Diabetic Male Rats

Nigella sativa and Non-Alcoholic Fatty Liver Disease: A Review of the Current Evidence

Nutritional Features and Bioactivities of Thymoquinone against Type 2 Diabetes Mellitus

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