Effects of Omega-3 Long Chain Polyunsaturated Fatty Acid Supplementation on Equine Synovial Fluid Fatty Acid Composition and Prostaglandin E2

Omega-3 fatty acid supplementation in horses

“…Synovial fluid fatty acid levels for EPA and DHA were significantly higher in the MARINE group compared to either CON or FLAX groups, indicating that direct supplementation of EPA and DHA is required if higher fluid concentrations of those fatty acids are desired (Ross-Jones et al, 2014). A small difference between treatment and control in synovial fluid PGE 2 concentration in the current study may be due to all horses being healthy and free of existing joint inflammation or disease.…”

“…Evaluation of synovial fluid in horses fed two different sources n-3 PUFA: a pilot study (Ross-Jones et al, 2014) Elevating n-3 PUFA in mammalian diets may downregulate inflammatory processes in the joint (Proudman et al, 2008) and has been shown to have symptom-modifying effects in inflammatory diseases (Lau et al, 1993). One hypothesized mechanism is the potential of long-chain n-3 PUFA to reduce the production of potent inflammatory eicosanoids (Chapkin et al, 2009), primarily PGE 2 .…”

“…One hypothesized mechanism is the potential of long-chain n-3 PUFA to reduce the production of potent inflammatory eicosanoids (Chapkin et al, 2009), primarily PGE 2 . In order to test the effects of different sources of n-3 PUFA on synovial fluid composition, the diets described on the first study (Hess et al, 2012) were supplemented for 90 days (Ross-Jones et al, 2014).…”

Serum Lipid Modification Related to Exercise and Polyunsaturated Fatty Acid Supplementation in Jumpers and Thoroughbred Horses

“…In horse nutritional research, the investigation of dietary polyunsaturated fatty acids (PUFAs) has grown in popularity on modifying inflammation, hematological and clotting parameters [6][7][8]. Several studies showed an effect of PUFAs supplementation on oxidative metabolism in athletic horse [1,9,10].…”

“…Omega-3 and omega-6 fatty acids are two of the most biologically significant PUFA classes. These essential fatty acids offer a variety of health-related benefits in a wide variety of physiological and pathologic conditions [6][7][8][9][10][11]. Moreover, there is some evidence that fat supplementation improve aerobic and anaerobic metabolism in horse by the increasing capacity of the uptake and the oxidation of fatty acids in muscle with consequent rise of muscle glycogen content and utilization rate during exercise [12].…”