2013
DOI: 10.1016/j.pnpbp.2013.08.005
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Abstract: . 2013, 'Effects of olanzapine and betahistine co-treatment on serotonin transporter, 5-HT2A and dopamine D2 receptor binding density ', vol. 47, Effects of olanzapine and betahistine co-treatment on serotonin transporter, 5-HT2A and dopamine D2 receptor binding density AbstractOlanzapine is widely used in treating multiple domains of schizophrenia symptoms but induces serious metabolic side-effects. Recent evidence has showed that co-treatment of betahistine (a histaminergic H1 receptor agonist and H3 recepto… Show more

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Cited by 30 publications
(41 citation statements)
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References 65 publications
(84 reference statements)
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“…Two studies investigated the effects of olanzapine and betahistine cotreatment on the 5-HT 2A R, 5-HT 2C R, 5-HTT, and D 2 R bindings in the brain regions associated with the therapeutic efficacy of antipsychotics, including the PFC, NAcC, NAcS and Cg, in both drug-naïve and chronic/repeated olanzapine-treated rats [195,196].…”
Section: Co-treatment With Betahistine Does Not Affect the Efficacy Omentioning
confidence: 99%
See 1 more Smart Citation
“…Two studies investigated the effects of olanzapine and betahistine cotreatment on the 5-HT 2A R, 5-HT 2C R, 5-HTT, and D 2 R bindings in the brain regions associated with the therapeutic efficacy of antipsychotics, including the PFC, NAcC, NAcS and Cg, in both drug-naïve and chronic/repeated olanzapine-treated rats [195,196].…”
Section: Co-treatment With Betahistine Does Not Affect the Efficacy Omentioning
confidence: 99%
“…It was shown that there was significant reduction of 5-HT 2A R binding density by olanzapine in various brain regions including the PFC, Cg, NAcC and NAcS [197,195,196,189,198].…”
Section: Co-treatment With Betahistine Does Not Affect the Efficacy Omentioning
confidence: 99%
“…Prior to drug treatment, rats were trained to self-administer a sweet cookie dough pellet (0.3 g, including 30.9% cornstarch, 30.9% sucrose, 6.3% gelatine, 15.5% casein, 6.4% fibre, 8.4% minerals and 1.6% vitamins) without drugs twice daily (b.i.d.) for one week Lian et al 2013) and were randomly assigned to one of following experiments (n=6/group). All animal experiments were conducted in accordance with the National Institute of Health Guide for the Care and Use of Laboratory Animals (Publication No.…”
Section: Animals and Housingmentioning
confidence: 99%
“…Furthermore, rats were closely housed in a room occupied by only female rats in this study. Our pre-experiments have shown that, under this rearing condition, the estrus cycles of all female rats are synchronized (Lian et al, 2013). It is also interesting that the NRG1-40kDa isoform was consistently affected by haloperidol and olanzapine, but not aripiprazole.…”
Section: Discussionmentioning
confidence: 64%
“…It is important that the drug dosages used in this study have been used previously and have been shown to be pharmacologically and behaviourally effective (Assié et al, 2006;Deng et al, 2007;Han et al, 2009a;WestonGreen et al, 2011). It should also be noted that female rats were used in this study, because our previous studies have shown that female rats are a suitable model for investigating pharmacological effects of antipsychotics (Han et al, 2009a;Han et al, 2009b;Han et al, 2008;Lian et al, 2013Lian et al, , 2014bMatosin et al, 2013). Furthermore, rats were closely housed in a room occupied by only female rats in this study.…”
Section: Discussionmentioning
confidence: 99%