Effects of Ocimum basilicum extract on hematological and serum profile of male albino mice after AlCl3 induced toxicity

Abstract

The present study was aimed to investigate the recovery effects of leave extract of Ocimum basilicum against AlCl3 induced toxicity. The trial was performed on adult male albino mice (Mus musculus). The experimental animals were randomly divided into three groups i.e. control, T1 and T2 with six animals in each group. Animals in control group received no treatment and were provided with normal saline. Both treatment groups T1 and T2 were orally administered with 80mg/kg body weight of AlCl3 for 16 days. After that animals in T1 and T2 groups were administered 100 mg/kg body weight and 200 mg/kg body weight respectively of Ocimum basilicum extract for 15 days. Several of the important hematological and serological parameters were measured. There was a significant increase in lymphocyte count and a significant decrease in neutrophil count in both T1 and T2 groups. There was a significant increase in red blood cells and platelet count while mean corpuscular haemoglobin was significantly decreased in T1 group. Alanine transaminase was significantly increased while serum creatinine was decreased in both T1 and T2 groups. It is concluded that Ocimum basilicum extract influenced several hematological and serological parameters in male albino adult mice after AlCl3 induced toxicity.

The Antioxidant and Hematopoietic Effects of the Methanolic Extract Fractions of Ocimum basilicum in Acetaminophen-Induced Albino Rats

“…(Then et al 2003;Maji and Banerji 2015;Degla et al 2022) Rats on low and high dose fraction ii caused an increase in RBC when compared to the control. This observation agrees with the findings of Saha et al (2012) in male swiss albino mice after benzene induced toxicity and Ali et al (2017) in male albino mice administered Ocimum basilicum extract after AlCl3-induced toxicity. This observation suggests that the secondary metabolites of O. basilicum L. methanolic fractions ii might contain an erythropoietin-like agent which may enhance the production of erythrocytes (Ali et al 2017).…”

“…This observation agrees with the findings of Saha et al (2012) in male swiss albino mice after benzene induced toxicity and Ali et al (2017) in male albino mice administered Ocimum basilicum extract after AlCl3-induced toxicity. This observation suggests that the secondary metabolites of O. basilicum L. methanolic fractions ii might contain an erythropoietin-like agent which may enhance the production of erythrocytes (Ali et al 2017). An increase in hemoglobin concentration seen in rats on low dose fraction ii compared to control is contrary to the reports of Jimoh et al (2008) who found that the administration of the aqueous extract of Ocimum gratissimum led to a decrease in hemoglobin.…”

PENGARUH EKSTRAK ETANOL DAUN KEMANGI (Ocimum bacilicum L.) TERHADAP KADAR β2 MIKROGLOBULIN, ASAM URAT DAN GAMBARAN HISTOLOGI GINJAL PADA TIKUS PUTIH GALUR WISTAR (Rattus novergicus strain Wistar) YANG DIINDUKSI MONOSODIUM GLUTAMAT

“…Indonesia merupakan negara berkembang yang masih menggunakan bahan alam sebagai obat tradisional, salah satunya adalah kemangi (Ocimum basilicum L). Dalam penelitian Ali, et al 1 menunjukkan adanya nefroprotektif dari pengaruh daun kemangi atau yang disebut basil, telah di ekstrak dosis 100 mg/kgBB dan 200 mg/kgBB yang telah diinduksi AlCl3 yang dilihat dari kadar ureum dan kreatinin. Pada penelitian Sumarni et al 2 menyatakan bahwa ekstrak kemangi dapat melarutkan batu ginjal kalsium, dimana uji kelarutan menunjukkan bahwa semakin tinggi konsentrasi ekstrak daun kemangi maka semakin besar kelarutannya.…”