Effects of ochratoxin A upon early and late events in human T-cell proliferation

Efeitos in vitro de ocratoxina A, deoxinivalenol e zearalenona sobre a viabilidade celular e atividade de E-ADA em linfócitos de frangos de corte

“…Essas diferentes conclusões podem ser devido às concentrações testadas da micotoxina, características particulares das linhagens celulares, diferentes condições de cultura, ao período de exposição e critérios utilizados no estudo (Alvarez-Ervitil et al 2005). Estudos demonstram que OCRA suprime a reposta de anticorpos em inúmeras espécies (Haubeck et al 1981, Harvey et al 1992, Stormer & Lea 1995, Müller et al 1999. Em relação à imunidade humoral, OCRA induz uma regressão dose--dependente das imunoglobulinas IgG, IgA e IgM (Müller et al 1995, Dortant et al 2001.…”

Efeitos in vitro de ocratoxina A, deoxinivalenol e zearalenona sobre a viabilidade celular e atividade de E-ADA em linfócitos de frangos de corte

“…Essas diferentes conclusões podem ser devido às concentrações testadas da micotoxina, características particulares das linhagens celulares, diferentes condições de cultura, ao período de exposição e critérios utilizados no estudo (Alvarez-Ervitil et al 2005). Estudos demonstram que OCRA suprime a reposta de anticorpos em inúmeras espécies (Haubeck et al 1981, Harvey et al 1992, Stormer & Lea 1995, Müller et al 1999. Em relação à imunidade humoral, OCRA induz uma regressão dose--dependente das imunoglobulinas IgG, IgA e IgM (Müller et al 1995, Dortant et al 2001.…”

Identification of novel metabolite and its cytotoxic effect on human lymphocyte cells in comparison to other mycotoxins

“…The resultant loss of lymphocyte cells provoked by all of the mycotoxins tested in this study may cause immunosupression as indicated by Sharma (1993), since cell mortality is the initial step of immunomodulation in animal species (Forsell et al, 1985) thus favouring infections. It is known, that T lymphocytes play a pivotal role in the immune system by being responsible for immune response (Stormer and Lea, 1995), acting as a natural defence mechanism against host invasion of diseases. While significant variations were noted at some concentrations, the tested mycotoxins were found to have similar effects with regards to causing cell mortality.…”

Occurrence, importance and control of mycotoxins: A review

“…Both OTA and citrinin are well-known nephrotoxins. OTA is also carcinogenic to rodents (Creppy et al, 1985) and possesses teratogenic (Arora et al, 1983), immunotoxic (Stormer and Lea, 1995), neurotoxic (Bruinink and Sidler, 1997;Sava et al, 2006), mutagenic (Stetina and Votava, 1986), and genotoxic (Meisner et al, 1983) properties. Compared to OTA, ochratoxin B is rarely found and very less toxic.…”

Efeitos in vitro de ocratoxina A, deoxinivalenol e zearalenona sobre a viabilidade celular e atividade de E-ADA em linfócitos de frangos de corte

“…Essas diferentes conclusões podem ser devido às concentrações testadas da micotoxina, características particulares das linhagens celulares, diferentes condições de cultura, ao período de exposição e critérios utilizados no estudo (Alvarez-Ervitil et al 2005). Estudos demonstram que OCRA suprime a reposta de anticorpos em inúmeras espécies (Haubeck et al 1981, Harvey et al 1992, Stormer & Lea 1995, Müller et al 1999. Em relação à imunidade humoral, OCRA induz uma regressão dose--dependente das imunoglobulinas IgG, IgA e IgM (Müller et al 1995, Dortant et al 2001.…”

Identification of novel metabolite and its cytotoxic effect on human lymphocyte cells in comparison to other mycotoxins

“…The resultant loss of lymphocyte cells provoked by all of the mycotoxins tested in this study may cause immunosupression as indicated by Sharma (1993), since cell mortality is the initial step of immunomodulation in animal species (Forsell et al, 1985) thus favouring infections. It is known, that T lymphocytes play a pivotal role in the immune system by being responsible for immune response (Stormer and Lea, 1995), acting as a natural defence mechanism against host invasion of diseases. While significant variations were noted at some concentrations, the tested mycotoxins were found to have similar effects with regards to causing cell mortality.…”

Occurrence, importance and control of mycotoxins: A review

“…Both OTA and citrinin are well-known nephrotoxins. OTA is also carcinogenic to rodents (Creppy et al, 1985) and possesses teratogenic (Arora et al, 1983), immunotoxic (Stormer and Lea, 1995), neurotoxic (Bruinink and Sidler, 1997;Sava et al, 2006), mutagenic (Stetina and Votava, 1986), and genotoxic (Meisner et al, 1983) properties. Compared to OTA, ochratoxin B is rarely found and very less toxic.…”

Efeitos in vitro de ocratoxina A, deoxinivalenol e zearalenona sobre a viabilidade celular e atividade de E-ADA em linfócitos de frangos de corte

“…Essas diferentes conclusões podem ser devido às concentrações testadas da micotoxina, características particulares das linhagens celulares, diferentes condições de cultura, ao período de exposição e critérios utilizados no estudo (Alvarez-Ervitil et al 2005). Estudos demonstram que OCRA suprime a reposta de anticorpos em inúmeras espécies (Haubeck et al 1981, Harvey et al 1992, Stormer & Lea 1995, Müller et al 1999. Em relação à imunidade humoral, OCRA induz uma regressão dose--dependente das imunoglobulinas IgG, IgA e IgM (Müller et al 1995, Dortant et al 2001.…”

Identification of novel metabolite and its cytotoxic effect on human lymphocyte cells in comparison to other mycotoxins

“…The resultant loss of lymphocyte cells provoked by all of the mycotoxins tested in this study may cause immunosupression as indicated by Sharma (1993), since cell mortality is the initial step of immunomodulation in animal species (Forsell et al, 1985) thus favouring infections. It is known, that T lymphocytes play a pivotal role in the immune system by being responsible for immune response (Stormer and Lea, 1995), acting as a natural defence mechanism against host invasion of diseases. While significant variations were noted at some concentrations, the tested mycotoxins were found to have similar effects with regards to causing cell mortality.…”

Occurrence, importance and control of mycotoxins: A review

“…Both OTA and citrinin are well-known nephrotoxins. OTA is also carcinogenic to rodents (Creppy et al, 1985) and possesses teratogenic (Arora et al, 1983), immunotoxic (Stormer and Lea, 1995), neurotoxic (Bruinink and Sidler, 1997;Sava et al, 2006), mutagenic (Stetina and Votava, 1986), and genotoxic (Meisner et al, 1983) properties. Compared to OTA, ochratoxin B is rarely found and very less toxic.…”