Effects of occlusive tape systems on the mitotic activity of epidermis. With and without corticosteroids

Fisher, L. B.

doi:10.1001/archderm.114.3.384

Cited by 6 publications

(3 citation statements)

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Section: Mechanisms Of Action Of Steroid Tapementioning

confidence: 99%

“…Additionally, a non-occlusive vehicle would assist in preventing certain adverse effects like irritation; this probably offsets the theoretical advantage of maximising the percutaneous absorption of the steroid via complete occlusion. 19 Additional mechanisms proposed for the therapeutic effect of occlusion include hydration of the stratum corneum 20 as well as retention of heat under the tape. 21 The role of these effects needs to be further elucidated. An additional hypothetical occlusion-related mechanism stems from the experience with silicone products for scar management.…”

Section: Mechanisms Of Action Of Steroid Tapementioning

confidence: 99%

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Steroid tape: A promising adjunct to scar management

Goutos¹,

Ogawa

2017

Scars, Burns & Healing

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Introduction:Intralesional steroid administration is a popular adjunct to scar management with numerous reports in the literature appraising this modality in hypertrophic and keloid scars. The percutaneous delivery of steroids using adhesive tape is an alternative modality, which was first described in the dermatological literature in the 1960s. It is infrequently used in most countries apart from the Orient, where it represents one of the mainstays of specialist scar management protocols.Methods:An English and Japanese literature review was performed and reports were stratified using the Joanna Briggs Institute Levels of Evidence. Data were extracted relating to the maximum dose of steroid that can be delivered safely, the reported therapeutic efficacy, as well as the side effects associated with the percutaneous delivery of steroids.Discussion:Steroid tape has the potential to be a safe and patient-friendly adjunct to scar management for carefully selected cases of keloid and hypertrophic scars. The main limitation for its widespread adoption is the lack of data to enable the determination of safe exposure thresholds in adult and paediatric patients.Conclusion:Despite the existing encouraging reports regarding the potential to be a useful adjunct in scar management, steroid tape is not widely used apart from a limited number of scar services worldwide. Further research is warranted to delineate the role of this modality in specialist scar management protocols.

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Section: Mechanisms Of Action Of Steroid Tapementioning

confidence: 99%

Section: Mechanisms Of Action Of Steroid Tapementioning

confidence: 99%

Steroid tape: A promising adjunct to scar management

Goutos¹,

Ogawa

2017

Scars, Burns & Healing

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“…and have antimitotic effects. Antimitotic effects may explain some of the therapeutic actions of the drug in scaling dermatoses such as psoriasis [13]. Glucocorticoids inhibit natural vasodilators such as histamine, bradykinins and prostaglandins [14].…”

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confidence: 99%

Tachyphylaxis to topical glucocorticoids; what is the evidence?

Taheri

Cantrell²,

Feldman³

2013

Dermatology Online Journal

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Background: Common belief holds that as topical glucocorticoids are used over time the less effective they become, a phenomenon called tolerance or tachyphylaxis. Objective:To determine what evidence supports the concept of tachyphylaxis to glucocorticoids. Methods:We searched Medline and Google Scholar for articles on tachyphylaxis to glucocorticoids published through October 2012.Results: Rapid tolerance, tachyphylaxis, to non-clinical effects of glucocorticoids has been reported in literature. However, clinically significant tolerance to topical glucocorticoids has not been identified in clinical trials. We did not identify any evidence that clinical efficacy of glucocorticoids in inflammatory skin diseases significantly diminishes during long term continuous use.Limitations: Tachyphylaxis or tolerance to clinical effects of topical glucocorticoids in inflammatory skin diseases is not fully characterized or well studied. Conclusion:Based on available data in literature, there is no clinical trial supporting the concept that topical glucocorticoids lose effectiveness over time, nor that intermittent use of topical glucocorticoids is more effective than continuous use. BackgroundTopical glucocorticoids are the foundation of dermatological treatment, with potent anti-inflammatory properties. Glucocorticoids act on a wide range of cells and have a wide range of mechanisms of action. Most of the effects of glucocorticoids on cells are mediated via the glucocorticoid receptor [1][2][3]. Glucocorticoids inhibit phospholipase A2, reducing the amount of arachidonic acid, decrease the release of interleukin (IL)-1α and IL-2, inhibit leucocyte migration to sites of inflammation, and interfere with the functions of endothelial cells, granulocytes, mast cells and fibroblasts [4][5][6][7][8][9][10]. Glucocorticoids also reduce T cell proliferation and increase T cell apoptosis, increase monocyte apoptosis, deplete the number of Langerhans cells, decrease histamine content of mast cells, and suppress eosinophil maturation, recruitment, and survival [11,12]. Topical glucocorticoids reduce protein synthesis

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Effects of hydrocortisone on the adrenaline-adenylate cyclase system of the skin

et al. 1980

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Using pig skin slices, we investigated the effects of hydrocortisone on the adenylate cyclase system of the skin. In short-term experiments, hydrocortisone, when added singly or in combination with other stimulators of adenylate cyclase in the skin (adrenaline or histamine), had no effect on cyclic AMP accumulation. However, when skin slices were incubated with hydrocortisone for more than 6 h, the response to adrenaline differed, with a greater accumulation of cyclic AMP in the hydrocortisone-treated skin. This effect was seen at a concentration of more than I micrometer hydrocortisone and was most marked 48 h later, while responses to adrenaline in control skin gradually decreased and remained low. Histamine, which is another stimulator of adenylate cyclase of the skin, did not cause a greater cyclic AMP accumulation in response to this hydrocortisone treatment. There was no significant difference in either low Km or high Km cyclic AMP phosphodiesterase activities as a result of this hydrocortisone treatment. Hydrocortisone seems to act by protecting the adrenaline-adenylate cyclase system of the skin.

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Effects of occlusive tape systems on the mitotic activity of epidermis. With and without corticosteroids

Cited by 6 publications

References 0 publications

Steroid tape: A promising adjunct to scar management

Steroid tape: A promising adjunct to scar management

Tachyphylaxis to topical glucocorticoids; what is the evidence?

Effects of hydrocortisone on the adrenaline-adenylate cyclase system of the skin

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