Effects of obesity on sGCβ1 mediated signaling in white adipose tissue

Sanyal, Abhishek; Hoffmann, Laura; Etzrodt, Jennifer; Pfeifer, Alexander

doi:10.1186/2050-6511-16-s1-a83

Cited by 1 publication

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References 6 publications

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“…Though the results of the last decade indicate that the activation of endothelial NO-synthase (eNOS), NO bioavailability, and recruitment of eNOS/NO/sGC/cGMP/PKG1-signaling chain may protect against obesity, by influencing differentiation and mitochondrial biogenesis in brown fat cells, adipogenesis and lipolysis in white cells, and so on. [15][16][17][18][19][20]. Besides that, controversial results on the role of Ca 2+ and calcium-sensing receptors in the regulation of body fat depots [21][22][23] point on the important role of Ca 2+ in the mechanisms of self-control of second messengers signaling systems.…”

Section: Calcium Camp and Cgmp-related Signaling Systems Operatingmentioning

confidence: 99%

Feedback Control of Second Messengers Signaling Systems in White Adipose Tissue Adipocytes in Healthy State and Its Loss at Adiposity

Дынник¹,

Grishina²,

Сирота³

et al. 2018

Adipose Tissue

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Second messengers Ca 2+ , IP3, cAMP, NO, cGMP, and cADP ribose are incorporated as obligatory elements into multivariable Ca 2+-signaling system, which integrates incoming signals of hormones and neurotransmitters in white adipocytes. This cross-controlled system includes two robust generators (RGs) of rhythmic processes, involving phospholipase C-and NO-synthase-dependent signaling networks (PLC-RG and NOS-RG). Multi-loop positive feedback control of both RGs provides their robustness, multistability, signaling interplay, and extreme sensitivity to the alterations of incoming signals of acetylcholine, norepinephrine, insulin, cholecystokinin, atrial natriuretic peptide, bradykinin, and so on. Hypertrophy of cultured adipocytes and of mature cells, isolated from epididymal white adipose tissue (eWAT), results in the loss of rhythmicity and development of general hormonal signaling resistance. Preadipocytes isolated from eWAT of obese mice cannot grow and accumulate lipids in the media devoid of fatty acids. However, even low concentrations of palmitoylcarnitine in the media (1 μM) may result in drastic suppression of mRNA expressions of the proteins of Ca 2+-signaling system, especially of NOS-RG. Similar alterations of gene expression are observed in eWAT and liver at adiposity. All this may indicate on universal background pathogenic mechanisms. Treatment modalities, which may help to restore deregulation of Ca 2+-signaling system and corresponding tissues dysfunction, are discussed briefly.

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