Effects of nutritional status on serum fetuin-A level

İçer, Mehmet Arif; Yıldıran, Hilal

doi:10.1080/10408398.2019.1631751

Cited by 13 publications

(10 citation statements)

References 89 publications

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“…Interaction between fetuin-A and sex and all other above-listed covariates was tested by creating cross product terms and evaluating the significance level. Because there is evidence that several dietary factors including coffee, dairy intake and omega-3 fatty acids are associated with circulating fetuin-A levels (for review see Icer and Yıldıran [ 32 ]), we also adjusted our analyses for these factors in sensitivity analyses.…”

Section: Methodsmentioning

confidence: 99%

Fetuin-A and risk of diabetes-related vascular complications: a prospective study

Birukov

Polemiti

Jäger

et al. 2022

Cardiovasc Diabetol

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Background Fetuin-A is a hepatokine which has the capacity to prevent vascular calcification. Moreover, it is linked to the induction of metabolic dysfunction, insulin resistance and associated with increased risk of diabetes. It has not been clarified whether fetuin-A associates with risk of vascular, specifically microvascular, complications in patients with diabetes. We aimed to investigate whether pre-diagnostic plasma fetuin-A is associated with risk of complications once diabetes develops. Methods Participants with incident type 2 diabetes and free of micro- and macrovascular disease from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort (n = 587) were followed for microvascular and macrovascular complications (n = 203 and n = 60, respectively, median follow-up: 13 years). Plasma fetuin-A was measured approximately 4 years prior to diabetes diagnosis. Prospective associations between baseline fetuin-A and risk of complications were assessed with Cox regression. Results In multivariable models, fetuin-A was linearly inversely associated with incident total and microvascular complications, hazard ratio (HR, 95% CI) per standard deviation (SD) increase: 0.86 (0.74; 0.99) for total, 0.84 (0.71; 0.98) for microvascular and 0.92 (0.68; 1.24) for macrovascular complications. After additional adjustment for cardiometabolic plasma biomarkers, including triglycerides and high-density lipoprotein, the associations were slightly attenuated: 0.88 (0.75; 1.02) for total, 0.85 (0.72; 1.01) for microvascular and 0.95 (0.67; 1.34) for macrovascular complications. No interaction by sex could be observed (p > 0.10 for all endpoints). Conclusions Our data show that lower plasma fetuin-A levels measured prior to the diagnosis of diabetes may be etiologically implicated in the development of diabetes-associated microvascular disease.

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Section: Methodsmentioning

confidence: 99%

Fetuin-A and risk of diabetes-related vascular complications: a prospective study

Birukov

Polemiti

Jäger

et al. 2022

Cardiovasc Diabetol

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“… 66 The sample size in our study (2305 participants) can be justified because our study was not intended to detect a causal association, but was rather, it aimed to estimate a causal effect. 67 Last, other factors such as nutritional intake and exercise might influence the serum fetuin-A level, 68 but we did not consider them because of a lack of data.…”

Section: Discussionmentioning

confidence: 99%

Causal association pathways between fetuin-A and kidney function: a mediation analysis

et al. 2022

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Objective Body mass index (BMI), uric acid, diabetes mellitus, and hypertension are risk factors for reduced kidney function and are associated with fetuin-A levels, but their causal pathways remain unclear. The objective of this study was to investigate this knowledge gap. Methods A repeated cross-sectional design was used to assess causal pathway effects of fetuin-A on the estimated glomerular filtration rate (eGFR), which is mediated through BMI, uric acid, diabetes mellitus, and hypertension. Results Among 2305 participants, the mean eGFR at baseline decreased from 98.7 ± 23.6 mL/minute/1.73 m2 in 2009 to 92.4 ± 22.9 mL/minute/1.73 m2 in 2014. Fetuin-A was significantly associated with eGFR , suggesting that increasing fetuin-A levels predict a decrease in eGFR. Additionally, the indirect effect of fetuin-A on eGFR, as assessed through BMI, was also significant. The effects of fetuin-A on eGFR through other mediation pathways showed variable results. Conclusions Our study revealed a possible role of fetuin-A in the etiology of declining renal function through mediating body mass index, uric acid, diabetes mellitus, and hypertension via complex causal pathways. Further studies to clarify these mediated effects are recommended.

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“…The increased Salb variability were common in patients with low and normal Salb levels, and we speculated that the rapid increase in Salb disrupted serum calcium phosphate levels and lipid metabolism, which resulted in increased BMI, obesity, poor survival, and cardiovascular-related mortality. [ 33 – 35 ]…”

Section: Discussionmentioning

confidence: 99%

Impact of serum albumin level and variability on short-term cardiovascular-related and all-cause mortality in patients on maintenance hemodialysis

et al. 2021

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Studies have shown that low serum albumin (Salb) levels are associated with a high risk of mortality among patients on maintenance hemodialysis (MHD); however, the impact of Salb variability on short-term cardiovascular mortality remains unclear. Herein, we investigated the association between Salb levels and Salb variability on short-term all-cause and cardiovascular-related mortality in patients on MHD.Eligible patients on MHD at Chongqing General Hospital between June 2017 and June 2020 were recruited in this study. Patients were grouped by Salb levels (normal Salb, ≥3.8 g/dL; low Salb, 3.4-3.8 g/dL; and lower Salb, 2-3.4 g/dL) and Salb variability (decreased, >5% loss; increased, >5% gain; and steady, 5% loss to 5% gain). Associations between Salb levels, Salb variability, and all-cause and cardiovascular-related mortality were analyzed using Cox regression models. A survival analysis was performed using the Kaplan-Meier analysis.We enrolled a total of 181 patients on MHD with an average age of 65 years (interquartile range [IQR], 53-75 years). The mean Salb level was 3.8 ± 0.6 g/dL (IQR 2.9-4.4 g/dL), and the median Salb variability was 2.6% per year (IQR, À4.1 to 6.5). Fifty-two (29%) patients died, including 31 (17%) patients who died due to cardiovascular-related causes. Compared with the other groups, the lower Salb group had higher all-cause mortality (P < .01). Cox regression analyses revealed that lower Salb levels and decreased Salb variability were independently associated with all-cause mortality (hazard ratio [HR] = 1.95, 95% confidence interval [CI] 1.103-3.452; HR = 2.245, 95% CI 1.084-4.650), whereas increased Salb variability was independently associated with cardiovascular-related mortality (HR = 2.919, 95% CI 1.178-7.234; P < .05).Lower Salb levels were an independent predictor of all-cause mortality in patients on MHD. Increased Salb variability was strongly associated with cardiovascular-related mortality in the same population, especially in the short-term and in patients with normal Salb levels. Significantly elevated Salb variability should be evaluated to reduce cardiovascular-related mortality.

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Effects of nutritional status on serum fetuin-A level

Cited by 13 publications

References 89 publications

Fetuin-A and risk of diabetes-related vascular complications: a prospective study

Fetuin-A and risk of diabetes-related vascular complications: a prospective study

Causal association pathways between fetuin-A and kidney function: a mediation analysis

Impact of serum albumin level and variability on short-term cardiovascular-related and all-cause mortality in patients on maintenance hemodialysis

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