Effects of norepinephrine, epinephrine, and dopamine infusions on oxygen consumption in volunteers

Ensinger, H.; Weichel, Thomas; Lindner, Karl H.; Grünert, A.; Ahnefeld, Friedrich Wilhelm

doi:10.1097/00003246-199310000-00018

Cited by 89 publications

(21 citation statements)

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“…Specifically, catecholamines increase metabolism by increasing oxygen consumption and glucose oxidation (Ensinger, Weichel, Lindner, Grunert, & Ahnefeld, 1993;Hoeks et al, 2003). In line with this, studies examining energy metabolism in patients with pheochromocytoma found HbA1c and resting energy expenditure to be significantly decreased after adrenalectomy (Okamura et al, 2015;Petrak et al, 2013).…”

Section: Discussionmentioning

confidence: 86%

The association between norepinephrine and metabolism in patients with major depression

Futtrup

Nordentoft²,

Elfving

et al. 2018

Neurology, Psychiatry and Brain Research

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Background: Previous studies indicate that levels of plasma norepinephrine (p-NE) are altered in depressed patients. However, it is unclear whether altered NE metabolism is involved in the pathogenic association between depression and cardiovascular disease. The aim of the present study was, firstly, to investigate if p-NE levels differ between patients with major depression and healthy controls. Secondly, the study sought to assess the associations between p-NE and metabolic variables in all participants. The third and final aim of the study was to assess if the associations between p-NE and metabolic variables are influenced by disease status (depression vs. healthy). Methods: 108 patients with major depression and 44 healthy controls were tested for levels of p-NE and metabolic variables that affect cardiovascular risk. Results: The median level of p-NE in depressed patients (DSM-IV) was 2636 pg/ml, (IQR 2094-3143) and 2279 pg/ml (IQR 2007-2562) in non-depressed controls (p = 0.013). However, the difference between p-NE levels was non-significant when adjusted for daily smoking (p = 0.138). Significant associations (p ≤ 0.05) were observed between p-NE and p-lipids, mean arterial blood pressure, p-insulin, quantitative insulin sensitivity check index as well as inflammatory markers. Conclusions: Elevated levels of p-NE observed in patients with major depression were attributable to daily smoking, rather than to the depressive disorder. Important associations were found between p-NE and metabolic variables that affect cardiovascular risk. This is interesting from a clinical point of view, since affected individuals may benefit from simple and inexpensive treatments that influence sympathetic activity. All associations were independent of disease status.

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Section: Discussionmentioning

confidence: 86%

The association between norepinephrine and metabolism in patients with major depression

Futtrup

Nordentoft²,

Elfving

et al. 2018

Neurology, Psychiatry and Brain Research

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“…As observed in healthy volunteers, norepinephrine dose-dependently increases whole body oxygen consumption between 0.06 and 0.2 µg/kg/min which could contribute to adverse effects in critically ill patients [49] despite increasing oxygen delivery, especially with underlying disturbed cell function. Under clinical conditions, the use of more invasive procedures, including pulmonary artery catheter, transjugular cannulation of the hepatic vein, assessment of hepatic indocyaninegreen clearance, endoluminal positioning of a tonometric gastric tube and laser Doppler catheters allows to determine cardiac index, hepatosplanchnic oxygen extraction, lactate production, alanine uptake, and blood flow, gastric mucosal pCO 2 production, and jejunal mucosal perfusion, respectively [9,21].…”

Section: Oxidative Metabolism and Organ Energeticsmentioning

confidence: 83%

Controversial Issues Concerning Norepinephrine and Intensive Care Following Severe Traumatic Brain Injury

Stover¹,

Steiger²,

Stocker

2006

Eur J Trauma

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“…Systemic metabolic effects have been demonstrated for dopexamine [14] , noradrenaline, adrenaline and dopamine [13] in awake, healthy volunteers. These metabolic effects resulted in an increased systemic oxygen uptake without an increase in lactate.…”

Section: Discussionmentioning

confidence: 99%

“…The combined effects may lead to increased splanchnic as well as systemic blood fl ows without changing the fractional splanchnic blood fl ow [12] . Besides haemodynamic effects, adrenergic drugs have metabolic consequences [13,14] , which may limit potentially benefi cial haemodynamic effects [15] . Using a rat model of aortic cross-clamping, we recently observed higher blood lactate levels when dopexamine, and lower blood lactate levels when dopamine was continuously infused [16] .…”

mentioning

confidence: 99%

Effects of Dopexamine in a Rat Model of Supracoeliac Aortic Cross-Clamping and Declamping

Studer¹,

Wu²,

Siegemund³

et al. 2006

Eur Surg Res

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This experimental study in rats was designed to demonstrate effects of dopexamine (3 µg kg^–1 min^–1, n = 6) or physiologic saline solution (n = 6) on systemic as well as regional perfusion during 30 min of supracoeliac aortic cross-clamping and during 180 min of reperfusion following declamping. Rats were surgically instrumented with arterial, right atrial and portal venous catheters, ultrasonic flow probes around the abdominal aorta, superior mesenteric and carotid artery, and a paediatric tonometer for intestinal mucosal PCO₂ measurement. During 120 min of reperfusion, fluid resuscitation was titrated to keep abdominal aortic blood flow above 80% of baseline values. We found that during cross-clamping, values of arterial lactate (p = 0.002) and intestinal tonometric PCO₂ (p = 0.018) were higher in the dopexamine group than in the control group.

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Effects of norepinephrine, epinephrine, and dopamine infusions on oxygen consumption in volunteers

Cited by 89 publications

References 0 publications

The association between norepinephrine and metabolism in patients with major depression

The association between norepinephrine and metabolism in patients with major depression

Controversial Issues Concerning Norepinephrine and Intensive Care Following Severe Traumatic Brain Injury

Effects of Dopexamine in a Rat Model of Supracoeliac Aortic Cross-Clamping and Declamping

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