Effects of nicotine on memory retrieval in mice

Zarrindast, Mohammad‐Reza; Sadegh, Marjan; Shafaghi, Bijan

doi:10.1016/0014-2999(95)00628-1

Cited by 60 publications

(31 citation statements)

References 36 publications

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“…High doses of apomorphine and bromocriptine as dopaminergic receptor agonists reduce the memory retrieval. High doses of sulpiride diminish memory retrieval by blocking Pre-synaptic D2 receptor (20). The above results confirm our finding about memory retrieval.In conclusion,methylphenidate may improve memory retention and retrieval probably due to releasing norepinephrine and dopamine in CNS and preventing re-uptake of these neurotransmitters.…”

Section: Discussionsupporting

confidence: 82%

Effect of Methylphenidate on Retention and Retrieval of Passive Avoidance Memory in Young and Aged Mice

Arzi

Hemmati

Karampour

et al. 2014

Jundishapur J Health Sci

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Background: Several studies showed that dopamine and norepinephrine improve retention and retrieval of memory. Methylphenidate is an enhancer of dopamine and norepinephrine in brain. Objectives: In the present study, the effect of methylphenidate was evaluated on retention and retrieval of memory in young and aged mice using passive avoidance apparatus. Materials and Methods: Animals were divided into groups (n = 8) as follows: test groups received electric shock plus methylphenidate (2.5, 5 and 10mg kg -1 , i. P.), control group received electric shock plus normal saline and blank group received only electric shock. In all groups, step-down latency for both retention and retrieval test of memory was measured. Methylphenidate was administered immediately after receiving electric shock in the retention test, but methylphenidate was administered 23.5 hours after receiving electric shock in the retrieval test. Results: The mean of step-down latency on day 4 was significantly higher compared to day 2 (P < 0.05) in all young and aged groups of mice. The best response was attained with 5 mg/kg of methylphenidate. In memory retention test, the mean of step-down latency in young groups that received 2.5 and 5 mg/kg methylphenidate was significantly longer(P < 0.05) than aged groups. However, this difference was not significant in memory retrieval test. Conclusions: Methylphenidate may improve memory retention and retrieval.

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Section: Discussionsupporting

confidence: 82%

Effect of Methylphenidate on Retention and Retrieval of Passive Avoidance Memory in Young and Aged Mice

Arzi

Hemmati

Karampour

et al. 2014

Jundishapur J Health Sci

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“…This is in accord with prior studies which have shown no improvement induced by nicotine in step-down latencies in young mice (9). However, they are not concordant with reports of the facilitatory effect of nicotine on avoidance learning in young mice (28) or rats (8,22). It has been suggested that the effects of nicotine on memory could be more easily observed in cholinergic deficient mice (9).…”

Section: Discussionsupporting

confidence: 55%

Effects of nicotine on motor activity, passive avoidance and plus‐maze behavior in aged NMRI and C57BL mice

Redolat

Vicens

Carrasco

2002

Neuroscience Res Communica

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SUMMARYThe aim of the present study is to evaluate the effects of nicotine (0.35 and 0.175 mg/kg) on locomotor activity, passive avoidance and plus maze behavior in aged mice of two strains (C57BL and NMRI). In a first experiment, aged mice of these strains were injected with nicotine or saline and immediately afterwards were put on the actimeter. Results showed that nicotine significantly decreased locomotor activity in C57 mice. In a second experiment, nicotine was administered before training and retention sessions of a passive avoidance task. Results indicated that 0.175 mg/kg nicotine significantly increased entry latency in aged NMRI mice but had no effects on C57 mice. In the last experiment, mice were injected with nicotine and 15 min later evaluated in the plus-maze for 5 min. It was observed that in NMRI mice no measure was significantly affected by nicotine but in C57 mice this drug significantly reduced the number of total entries, number of entries in open arms and in the central area of the maze. It is concluded that in aged mice nicotine effects depend on the baseline behaviors of the strains evaluated.

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“…There is also evidence of nicotinic effects on memory retrieval from inhibitory avoidance studies. Systemic nicotine administration 15 min prior to a retrieval test increased inhibitory avoidance (Zarrindast et al 1996). This effect was opposed by the centrally acting antagonist mecamylamine but not the peripherally acting antagonist hexamethonium or the muscarinic antagonist atropine.…”

Section: Pharmacological Nicotinic Manipulations and Pavlovian Fear Cmentioning

confidence: 87%

The Role of Muscarinic and Nicotinic Cholinergic Neurotransmission in Aversive Conditioning: Comparing Pavlovian Fear Conditioning and Inhibitory Avoidance

Tinsley

Quinn²,

Fanselow³

2004

Learn. Mem.

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Effects of nicotine on memory retrieval in mice

Cited by 60 publications

References 36 publications

Effect of Methylphenidate on Retention and Retrieval of Passive Avoidance Memory in Young and Aged Mice

Effect of Methylphenidate on Retention and Retrieval of Passive Avoidance Memory in Young and Aged Mice

Effects of nicotine on motor activity, passive avoidance and plus‐maze behavior in aged NMRI and C57BL mice

The Role of Muscarinic and Nicotinic Cholinergic Neurotransmission in Aversive Conditioning: Comparing Pavlovian Fear Conditioning and Inhibitory Avoidance

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