Effects of nickel on catalase activity in vitro and in vivo

Characterization of partially purified catalase from camel (Camelus dromedarius) liver

“…The decomposition of H 2 O 2 by catalase was measured in a cell-free in vitro system in the presence of 0 to 24 mM Ni 2+ or Mg 2+ as well as in red blood cells (RBCs), and in post-mitochondrial fractions of liver and kidney of rats. The inhibition of the catalytic activity of catalase was directly proportional to Ni 2+ concentration, while Mg 2+ had no effect (Rodriguez et al, 1990).…”

Characterization of partially purified catalase from camel (Camelus dromedarius) liver

“…The decomposition of H 2 O 2 by catalase was measured in a cell-free in vitro system in the presence of 0 to 24 mM Ni 2+ or Mg 2+ as well as in red blood cells (RBCs), and in post-mitochondrial fractions of liver and kidney of rats. The inhibition of the catalytic activity of catalase was directly proportional to Ni 2+ concentration, while Mg 2+ had no effect (Rodriguez et al, 1990).…”

NiCl2-Down-Regulated Antioxidant Enzyme mRNA Expression Causes Oxidative Damage in the Broiler’s Kidney

“…The inhibition of SOD may be responsible for excessive ROS production, which causes enzyme protein fragmentation and overwhelms SOD activity [35]. And the suppressive effect of Ni 2+ on CAT activity is explained either by direct binding of Ni 2+ to the CAT molecule to change protein structure, or by replacement of iron in catalytic heme center with Ni 2+ [36]. Reduction of the SOD and CAT activities enhances ROS production and H 2 O 2 generation [19].…”

P2000 - A high-nitrogen austenitic steel for application in bone surgery

“…The increased risk of cold welding and the high production costs of titanium on one hand, and the release of metal ions such as nickel by 316L steel on the other hand created needs to search for alternative alloys. Besides causing allergic reactions in patients, nickel has also been shown to inhibit the catalytic activity of enzymes (for example catalase [30] and glutathione reductase [31]). Referring to bone physiology, it has been demonstrated that catalytic activity of ALP is inhibited by metal ions like aluminum or nickel [32,33].…”

Characterization of partially purified catalase from camel (Camelus dromedarius) liver

“…The decomposition of H 2 O 2 by catalase was measured in a cell-free in vitro system in the presence of 0 to 24 mM Ni 2+ or Mg 2+ as well as in red blood cells (RBCs), and in post-mitochondrial fractions of liver and kidney of rats. The inhibition of the catalytic activity of catalase was directly proportional to Ni 2+ concentration, while Mg 2+ had no effect (Rodriguez et al, 1990).…”

NiCl2-Down-Regulated Antioxidant Enzyme mRNA Expression Causes Oxidative Damage in the Broiler’s Kidney

“…The inhibition of SOD may be responsible for excessive ROS production, which causes enzyme protein fragmentation and overwhelms SOD activity [35]. And the suppressive effect of Ni 2+ on CAT activity is explained either by direct binding of Ni 2+ to the CAT molecule to change protein structure, or by replacement of iron in catalytic heme center with Ni 2+ [36]. Reduction of the SOD and CAT activities enhances ROS production and H 2 O 2 generation [19].…”

P2000 - A high-nitrogen austenitic steel for application in bone surgery

“…The increased risk of cold welding and the high production costs of titanium on one hand, and the release of metal ions such as nickel by 316L steel on the other hand created needs to search for alternative alloys. Besides causing allergic reactions in patients, nickel has also been shown to inhibit the catalytic activity of enzymes (for example catalase [30] and glutathione reductase [31]). Referring to bone physiology, it has been demonstrated that catalytic activity of ALP is inhibited by metal ions like aluminum or nickel [32,33].…”

Characterization of partially purified catalase from camel (Camelus dromedarius) liver

“…The decomposition of H 2 O 2 by catalase was measured in a cell-free in vitro system in the presence of 0 to 24 mM Ni 2+ or Mg 2+ as well as in red blood cells (RBCs), and in post-mitochondrial fractions of liver and kidney of rats. The inhibition of the catalytic activity of catalase was directly proportional to Ni 2+ concentration, while Mg 2+ had no effect (Rodriguez et al, 1990).…”

NiCl2-Down-Regulated Antioxidant Enzyme mRNA Expression Causes Oxidative Damage in the Broiler’s Kidney

“…The inhibition of SOD may be responsible for excessive ROS production, which causes enzyme protein fragmentation and overwhelms SOD activity [35]. And the suppressive effect of Ni 2+ on CAT activity is explained either by direct binding of Ni 2+ to the CAT molecule to change protein structure, or by replacement of iron in catalytic heme center with Ni 2+ [36]. Reduction of the SOD and CAT activities enhances ROS production and H 2 O 2 generation [19].…”

P2000 - A high-nitrogen austenitic steel for application in bone surgery

“…The increased risk of cold welding and the high production costs of titanium on one hand, and the release of metal ions such as nickel by 316L steel on the other hand created needs to search for alternative alloys. Besides causing allergic reactions in patients, nickel has also been shown to inhibit the catalytic activity of enzymes (for example catalase [30] and glutathione reductase [31]). Referring to bone physiology, it has been demonstrated that catalytic activity of ALP is inhibited by metal ions like aluminum or nickel [32,33].…”