Effects of Nanodiamonds of Explosive Synthesis on the Skin of Experimental Animals Locally Exposed to Cobalt and Chrome Ions

Prokhorenkov, V. I.; Vasil’eva, E. Yu.; Puzyr, A. P.; Bondar, V. S.

doi:10.1007/s10517-014-2737-0

Cited by 3 publications

(2 citation statements)

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“…The functionalization influence of detonation DNPs on their biocompatibility is controversial. Detonation nanodiamonds covered by cobalt ions showed a protective effect against contact dermatitis in mini-pigs, induced by local exposure of the animal skin to these ions [101]. Detonation nanodiamonds with hyperbranched polyglycerol coating showed good cytocompatibility with A549 cancer cells and U937 macrophages [54].…”

Section: The Potential Cytotoxicity Of Diamond Nanoparticlesmentioning

confidence: 98%

The Application of Nanodiamond in Biotechnology and Tissue Engineering

Bačáková¹,

Brož²,

Lišková³

et al. 2016

Diamond and Carbon Composites and Nanocomposites

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Diamond in the allotrope form consists of carbon atoms arranged in a cubic crystal structure covalently bonded in sp 3 hybridization. Diamond has emerged as a very promising material for various biomedical applications due to its excellent mechanical properties (hardness, low friction coefficient, good adhesiveness to the underlying substrate, good interlayer cohesion), optical properties (the ability to emit intrinsic luminescence), electrical properties (good insulator in the pristine state and semiconductor after doping), chemical resistance (low chemical reactivity and resistance to wet etching) and biocompatibility (little if any toxicity and immunogenicity). For advanced biomedical applications, diamond is promising particularly in its nanostructured forms, namely nanoparticles, nanostructured diamond films and composite scaffolds in which diamond nanoparticles are dispersed in a matrix (mainly nanodiamond-loaded nanofibrous scaffolds). This chapter summarizes both our long-term experience and that of other research groups in studies focusing on the interaction of cells (particularly bone-derived cells) with nanodiamonds as nanoparticles, thin films and composites with synthetic polymers. Their potential applications in bioimaging, biosensing, drug delivery, biomaterial coating and tissue engineering are also reviewed.

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Section: The Potential Cytotoxicity Of Diamond Nanoparticlesmentioning

confidence: 98%

The Application of Nanodiamond in Biotechnology and Tissue Engineering

Bačáková¹,

Brož²,

Lišková³

et al. 2016

Diamond and Carbon Composites and Nanocomposites

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“…Co ions were shown to adsorb to the surface of nanodiamonds in one study, preventing the elicitation of ACD reactions to the metal (1016). Interactions between metal ions and nanoparticles have been shown to augment many other immunological processes including DC maturation and macrophage activation in vitro, as well as pulmonary inflammation and ACD elicitation in vivo (727,769,1017,1018) Likewise, sequestration of haptenic or immunogenic metal ions as a result of adsorption to nanomaterials has the capacity to impede their capacity to induce or elicit allergic responses.…”

Section: Molecular Alterations In Immunogenicitymentioning

confidence: 99%

Metal Nanomaterials: Immune Effects and Implications of Physicochemical Properties on Sensitization, Elicitation, and Augmentation of Allergic Disease

Roach¹

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The recent surge in incorporation of engineered metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings has raised concerns over their potential to induce material size-specific toxicological effects. Although metal nanomaterials have been shown to induce greater degrees of lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy.Overall, more scientific knowledge exists regarding the potential for metal-containing nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Despite the existence of such knowledge, specific correlations between metal nanomaterial physico-chemical properties and their allergic effects have yet to be consistently demonstrated. As the number of emerging nanomaterials continues to increase, the delineation of these relationships has the potential to advance risk assessment efforts by helping to identify specific agents that may present an elevated risk for allergic effects.Two sets of studies were designed to begin addressing some of the knowledge gaps associated with the immunotoxic potential of metal nanomaterials in the context of allergic disease. The hypothesis of these studies was that nanomaterials comprised of metal constituents with known immunomodulatory potential augment, induce, and elicit allergic disease more readily than larger forms of the materials. Moreover, the nature of the immune responses caused by exposure to these metal nanomaterials, as well as the magnitude of the effects, correlates best with the parameter of dose surface area.The first set of studies incorporated NiO particles with different physico-chemical properties into an in vivo time course study and OVA asthma model. Results from the time course study demonstrated that the smaller NiO particles caused more pronounced pulmonary injury and inflammation, a discrepancy that could be mitigated by normalizing the administered particle dose to the surface area of the larger material. In the OVA model, augmentation of the allergic response was largely conserved with respect to NiO surface area, wherein larger doses caused polarization of pulmonary immune reposes towards a Th1/17-dominant state and smaller doses induced Th2-skewed responses. Despite this association, several immune markers, including total IgE production, BAL eosinophil number, and Penh response correlated better with other metrics, such as particle size.The second set of studies employed Au particles and nanoparticles to assess size-specific differences in allergenic potential. Neither particle was associated with potential for skin...

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