Effects of Myocardial Revascularization Following Acute Coronary Occlusion in Pigs

Althaus, U; Janett, J.; Schöll, E; Riedwyl, Hans

doi:10.1111/j.1365-2362.1976.tb00487.x

Cited by 17 publications

(19 citation statements)

References 22 publications

(2 reference statements)

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“…Pigs were chosen because the development of coronary anastomoses and collaterals are not subjected to wide variations found in the canine heart [ 10-121 ; moreover, the major coronary distribution and blood supply to the conduction system are similar to man [ 13, 141 . In a preliminary study we have shown that a perfusion deficit of reproducible size can be created by controlled coronary ligation in the pig [9], thus confirming the suitability of the pig heart for this experimental problem.…”

Section: Methodssupporting

confidence: 57%

Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings

Althaus

Gurtner

Baur

et al. 1977

Eur J Clin Investigation

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The effects of myocardial reperfusion have been examined following a 1 h coronary occlusion and compared to a permanent coronary ligation in pigs. Haemodynamic investigations were carried out throughout the surgical intervention and repeated after 7 days. Cellular injury was estimated by serial serum enzyme determinations (creatin phosphokinase, alpha-hydroxybutyric dehydrogenase, aspartate aminotransferase, lactic dehydrogenase) during the first 5 postoperative days; infarct size was assessed morphometrically by a histochemical staining procedure 1 week after the temporary or permanent coronary occlusion. A linear correlation was found between the logarithmically plotted peak serum activity of AST, HBDH, CPK and the morphometrically determined infarct size. Based upon enzyme and morphometrical studies no significant difference could be detected between the two experimental groups. In the animals subjected to transient coronary occlusion, however, the development of a ventricular aneurysm had been prevented to early and sustained reperfusion. Early re-establishment of coronary circulation appears to accelerate the proliferation of a more resistant granulation tissue into the infarcted area. Cardiac performance was not improved by myocardial reperfusion.

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Section: Methodssupporting

confidence: 57%

Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings

Althaus

Gurtner

Baur

et al. 1977

Eur J Clin Investigation

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“…The preservation of ischemic myocardium by early revascularization in animal models is a controversial issue (10)(11)(12)(13)(14)(15)(16)(17). Variability in experimental results may be due to many factors, including differences in collateral flow within (18) and between…”

Section: Resultsmentioning

confidence: 99%

“…Collateral circulation in pigs is less extensive than in dogs (19), and an equivalent coronary occlusion producing primarily a subendocardial infarction in the dog, results in a transmural infarct in the pig (20). In contrast to reperfusion in dogs, reperfusion 3 h after coronary artery occlusion in pigs does not result in any salvage of the area at risk (16,17). We studied baboons because their coronary anatomy closely resembles that of man (21,22).…”

Section: Discussionmentioning

confidence: 99%

Coronary thrombolysis and infarct size reduction after intravenous infusion of recombinant tissue-type plasminogen activator in nonhuman primates.

Flameng¹,

Werf²,

Vanhaecke³

et al. 1985

J. Clin. Invest.

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Occlusive thrombus was produced by thrombin-induced coagulation in the left anterior descending coronary artery (LAD) of 16 open-chest baboons. In six control animals, occlusive thrombosis persisting over a period of 4 h as evidenced by coronary arteriography resulted in large transmural infarction (63.1±3.5% of the perfusion area). In 10 animals, tissue-type plasminogen activator obtained by recombinant DNA technology (rt-PA) was infused systemically at a rate of 1,000 IU (10 isg)/kg per min for 30 min after 30-80 min of coronary thrombosis. Reperfusion occurred within 30 min in nine animals. In one animal, intravenous infusion was followed by an intracoronary infusion at the same rate, which resulted in thrombolysis within 8 min. In the rt-PA group, mean duration of occlusion before reperfusion was 77±24 min. Reocclusion occurred in one animal. Recanalization resulted in an overall reduction of infarct size (37.8±5.9%, P < 0.05 versus controls). Residual infarction was related to the duration of occlusion (r = 0.80, P < 0.01). Reperfusion was associated with reduced reflow. Myocardial blood flow in the perfusion area of the LAD was only 70% of normal after 4 h despite perfect angiographic refilling.The infusion of rt-PA was not associated with systemic activation of the fibrinolytic system, fibrinogen breakdown, or clinically evident bleeding.It is concluded that intravenous infusion of rt-PA may recanalize thrombosed coronary vessels without inducing systemic lysis. The extent of residual infarction is closely related to the duration of coronary artery occlusion before thrombolysis.

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“…The suitability of the pig heart for our experimental design was demonstrated in a preliminary study, where a pefusion deficit of reproducible size could be created by controlled coronary ligation (Althaus et al, 1976).…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, in recent years experimental and clinical research has been increasingly directed to the measurement and control of myocardial infarct size (Althaus et a/., 1976;Hillis and Braunwald 1977; Maroko e t a / . , 1971;Yusuf and Sleight 1984).…”

Section: Introductionmentioning

confidence: 99%

Effects of pindolol therapy on the size of experimentally induced myocardial infarction in the pig

Friedli

Althaus

Magnenat

et al. 1986

Clinical Cardiology

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Summary: The effect of pindolol on experimental myocardial infarction was studied in a pig model. Intravenous application of 0.05 mg pindolol per kg body weight was initiated one hour after coronary ligation and repeated at 12-hour intervals for five days. No significant difference in infarct size could be found between pindolol-treated animals (20.4f0.6% SEM of whole ventricular mass, n=6) and untreated controls (20.5+1.2% SEM, n=9). Hemodynamic data did not change significantly throughout the experiment. These results differ in pa; from those reported by other investigators: The disagreement may be due to the specific pharmacological properties of the applied drug, to variations in the dosages of beta blockers, as well as to differences in the study design.

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Effects of Myocardial Revascularization Following Acute Coronary Occlusion in Pigs

Cited by 17 publications

References 22 publications

Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings

Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings

Coronary thrombolysis and infarct size reduction after intravenous infusion of recombinant tissue-type plasminogen activator in nonhuman primates.

Effects of pindolol therapy on the size of experimentally induced myocardial infarction in the pig

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