Effects of muscle strength and aerobic training on basal serum levels of IGF-1 and cortisol in elderly women

Vale, Rodrigo Gomes de Souza; Oliveira, Rosana Dias de; Pernambuco, Carlos Soares; Meneses, Yúla Pires da Silveira Fontenele de; Novaes, Jefferson da Silva; Andrade, Armèle Dornelas de

doi:10.1016/j.archger.2008.11.011

Cited by 92 publications

(78 citation statements)

References 28 publications

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“…21,[243][244][245][246] However, addition of exogenous IGF-1 fails to increase the accuracy of regeneration or functional outcomes such as muscle power, motor evoked potentials and conduction velocity. 247,248 Although IGF-1 mediates exercise-induced anabolic changes in muscle tissue, [249][250][251] it is not known whether this neurotrophic factor is involved in stimulation- After FFA and handling in IGF-1 +/-mice, the pattern was similar (whisking amplitude 57% lower than intact;…”

Section: Recovery Of Whisking Function Promoted By Manual Stimulationmentioning

confidence: 99%

Experimental studies on post-transectional facial nerve regrowth and functional recovery of paralyzed muscles of the face in rats and mice

Skouras¹,

Angelov²

2010

Anatomy

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The facial nerve is the most frequently damaged nerve in head and neck traumata. Apart from traffic-accident injuries (temporal bone fractures, or lacerations of the face), most facial nerve lesions are post-operative AbstractInsufficient recovery after peripheral nerve injury has been attributed to (i) lack of axonal navigation and poor pathfinding of regrowing axons to improper targets, (ii) excessive collateral axonal branching at the lesion site and (iii) polyneuronal reinnervation of the neuromuscular junctions (NMJ). The facial nerve transection model in rat and mice has been used to measure the restoration of function after varying therapies and to examine the mechanisms underlying their effects. Since it is still very difficult to combat the first reason and control/correct the navigation of several thousand axons, several groups of scientists concentrated our efforts on the postlesional branching (extremely strong in adult rats) and NMJ-polyinnervation. Since polyneuronal innervation of muscle fibers is activity-dependent attempts to reduce it were performed applying electrical stimulation. Unfortunately, the highly recommended intraoperative electrical stimulation of the proximal nerve fragment (square 0.1 ms pulses at 20 Hz using suprathreshold amplitudes) prior to suture and the postoperative electrical stimulation (square 0.1 ms pulses at 5 Hz) not only did not improve functional outcome, but reduced the number of innervated NMJ to approximately one fifth of normal values. Finally, recent experiments demonstrated that it was the mechanical (but not electrical) stimulation of denervated facial muscles (vibrissal and orbicularis oculi) which improved motor performance. This beneficial effect of mechanical stimulation was also detected after hypoglossal-facial anastomosis and inter-positional nerve grafting. The beneficial effect of manual stimulation on target muscle reinnervation was not present in mice deficient in the expression of insulin-like growth factor 1 and also eliminated or even reversed when trigeminal afferent inputs were abolished. All these findings raise hopes that clinically feasible and effective therapies could be soon designed and tested.

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Section: Recovery Of Whisking Function Promoted By Manual Stimulationmentioning

confidence: 99%

Experimental studies on post-transectional facial nerve regrowth and functional recovery of paralyzed muscles of the face in rats and mice

Skouras¹,

Angelov²

2010

Anatomy

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“…Importantly, muscle hypertrophy is accompanied by increased local synthesis of IGF-I (Yan et al, 1993), which eventually reaches the circulation (Brahm et al, 1997). This means that muscle mass may inform the brain through transient increases in levels of serum IGF-I (Shelmadine et al, 2009;Vale et al, 2009). In turn, greater muscle development as a consequence of improved body fitness requires better motor coordination, increased metabolic demands (that are ultimately controlled by brain centers), and broadly improved brain function.…”

Section: Serum Igf-i: a Two-way Signal Connecting The Brain With The mentioning

confidence: 99%

Toward a comprehensive neurobiology of IGF‐I

Torres‐Alemán

2010

Developmental Neurobiology

115

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Imatinib is the drug of first choice for most patients with chronic phase chronic myeloid leukemia (CML). Although it is generally well tolerated, a number of hematological and nonhematological side‐effects have been described. We report here that imatinib induces hypophosphatemia in a high proportion of our series of CML patients previously treated with interferon α, and that this previously unreported side effect is associated with response. Am. J. Hematol., 2007. © 2006 Wiley‐Liss, Inc.

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“…Among the different types of exercises that influenced the IGF-1 serum levels in the elderly, increases of this hormone were found with strength training 21,22,24 The interventions ranged from two to three times per week, during three to six months.…”

Section: -23mentioning

confidence: 99%

“…22,25 This may improve functional autonomy 28 and quality of life in aging. 29 Therefore, due to the benefits of higher levels of IGF-1 in the elderly, it is suggested to extend the knowledge of means that can possibly increase the synthesis and release of this hormone.…”

Section: -23mentioning

confidence: 99%

Insulin-Like Growth Factor I (IGF-1) In Older Adults: A Review

Br¹,

Castro²,

Vale³

2017

MOJGG

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Submit Manuscript | http://medcraveonline.com to increased growth hormone (GH) levels, but it can also be produced in other tissues, including skeletal muscles and bones. 7 The IGF-1 provides information about the rate of bone remodeling, related to bone mineral density (BMD) 8 and exerts, on the bones, an anabolic effect on the osteoblasts, increasing the cellular proliferation and estimating the synthesis of the bone mineral matrix. 9The IGF-1 generates an anabolic effect on skeletal muscle, related to the preservation of lean body mass.10 Accordingly, the reduction of IGF-1 due to aging may be associated with greater susceptibility to sarcopenia and functional dependence 11,12 loss of lean mass, decreased protein synthesis, increased fat mass 13 and myostatin in elderly individuals.14 Consequently, higher levels of IGF-1 are associated with improvements in physical fitness 15 and lean body mass 10, and reduced risk of heart disease 16 and mortality. 17Physical exercises may influence the secretion of hormones in the elderly. 18 The hormonal impact of physical exercise can help to verify the effectiveness of training programs to maintain or improve IGF-1 levels and to determine the potential effects of different types of exercise on this hormone. However, the training programs presented methodological differences, such as the type of exercise used, the intensity and the volume of training. 19-23Among the different types of exercises that influenced the IGF-1 serum levels in the elderly, increases of this hormone were found with strength training 21,22,24 The interventions ranged from two to three times per week, during three to six months.Muscle strength training has shown higher increases in IGF-1 levels in the elderly compared to endurance training. 22,25 This may improve functional autonomy 28 and quality of life in aging. 29Therefore, due to the benefits of higher levels of IGF-1 in the elderly, it is suggested to extend the knowledge of means that can possibly increase the synthesis and release of this hormone. Thus, future researches should investigate the effects on IGF-1 of different configurations of intensity and volume of training, as well as different types of exercises. AcknowledgementsNone. Conflict of interestAuthor declares there is no conflict of interest in publishing the article.

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Effects of muscle strength and aerobic training on basal serum levels of IGF-1 and cortisol in elderly women

Cited by 92 publications

References 28 publications

Experimental studies on post-transectional facial nerve regrowth and functional recovery of paralyzed muscles of the face in rats and mice

Experimental studies on post-transectional facial nerve regrowth and functional recovery of paralyzed muscles of the face in rats and mice

Toward a comprehensive neurobiology of IGF‐I

Insulin-Like Growth Factor I (IGF-1) In Older Adults: A Review

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