Effects of Motor Cortex Modulation and Descending Inhibitory Systems on Pain Thresholds in Healthy Subjects

Reidler, Jay S.; Mendonça, Mariana E.; Santana, Marcus B.; Wang, Xiaoen; Lenkinski, Robert E.; Motta, Andréa Fontoura; Marchand, Serge; Latif, Lydia Abdul; Fregni, Felipe

doi:10.1016/j.jpain.2012.01.005

Cited by 90 publications

(114 citation statements)

References 57 publications

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“…The increase in pain sensitivity might be due to the neuroplastic effects of chronic stress on pain circuitry i.e. the diffuse noxious inhibitory control system (DNIC) [9], [11]. DNIC is an endogenous pathway mediating inhibition of lamina I neurons in the spinal dorsal root when pain signals ascend from the periphery through sensory C fiber neurons distributed wide spread over the body in the epidermis and up through the spinal cord [11].…”

Section: Introductionmentioning

confidence: 99%

“…the diffuse noxious inhibitory control system (DNIC) [9], [11]. DNIC is an endogenous pathway mediating inhibition of lamina I neurons in the spinal dorsal root when pain signals ascend from the periphery through sensory C fiber neurons distributed wide spread over the body in the epidermis and up through the spinal cord [11]. Patients with hypersensitivity to pain have been shown to have an impaired DNIC modulation [12], [13].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Daily Self-Measurement of Pressure Pain Sensitivity Followed by Acupressure on Depression and Quality of Life versus Treatment as Usual in Ischemic Heart Disease: A Randomized Clinical Trial

et al. 2014

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BackgroundDepressive symptoms and reduced quality of life (QOL) are parts of the chronic stress syndrome and predictive of adverse outcome in patients with ischemic heart disease (IHD). Chronic stress is associated with increased sensitivity for pain, which can be measured by algometry as Pressure Pain Sensitivity (PPS) on the sternum.AimTo evaluate if stress focus by self-measurement of PPS, followed by stress reducing actions including acupressure, can decrease depressive symptoms and increase psychological well-being in people with stable IHD.DesignObserver blinded randomized clinical trial over 3 months of either intervention or treatment as usual (TAU). Statistical analysis: Intention to treat.MethodsTwo hundred and thirteen participants with IHD were included: 106 to active treatment and 107 to TAU. Drop-out: 20 and 12, respectively. The active intervention included self-measurement of PPS twice daily followed by acupressure as mandatory action, aiming at a reduction in PPS. Primary endpoint: change in depressive symptoms as measured by Major depression inventory (MDI). Other endpoints: changes in PPS, Well-being (WHO-5) and mental and physical QOL (SF-36).ResultsAt 3 months PPS decreased 28%, to 58, in active and 11%, to 72, in TAU, p<0.001. MDI decreased 22%, to 6.5, in active group vs. 12%, to 8.3 in TAU, p = 0.040. WHO-5 increased to 71.0 and 64.8, active group and TAU, p = 0.015. SF-36 mental score sum increased to 55.3 and 53.3, active and TAU, p = 0.08.ConclusionsPPS measurements followed by acupressure reduce PPS, depressive symptoms and increase QOL in patients with stable IHD.Trial RegistrationClinicalTrials.gov NCT01513824

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Daily Self-Measurement of Pressure Pain Sensitivity Followed by Acupressure on Depression and Quality of Life versus Treatment as Usual in Ischemic Heart Disease: A Randomized Clinical Trial

et al. 2014

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“…28 Specific to exercise, the ability to engage descending inhibitory pathways may augment another unknown mechanism to explain the effect of exercise duration on EIH in young adults. 9,25 Isometric contractions of both short and longer duration produce EIH; however, the greatest EIH response occurs with longer-duration isometric contractions that typically induce more pain as the duration increases.…”

mentioning

confidence: 99%

Conditioned Pain Modulation Predicts Exercise-Induced Hypoalgesia in Healthy Adults

Lemley

Hunter

Bement

2015

Medicine &Amp; Science in Sports &Amp; Exercise

112

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Introduction: Conditioned pain modulation (CPM) is the concept that pain inhibits pain and has potential rehabilitation implications for exercise prescription. The purpose of this study was to determine whether changes in pressure pain perception after a thermal conditioning stimulus (i.e., CPM) was attenuated with aging and whether CPM predicted pain relief after exercise (exercise-induced hypoalgesia (EIH)) in healthy young and older adults.

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“…Moreover, antidepressant pharmacotherapy (i.e., in the multimodal treatment of chronic pain [35]) also offers additional benefits via modulatory effects on central pathways associated with pain processing [36,37]. Therefore, tDCS may also offer an alternative method of intervention by modulating pain processing in these central pathways.…”

Section: Painmentioning

confidence: 99%

Transcranial direct current stimulation: neurophysiology and clinical applications

Knechtel¹,

Thienel²,

Schall³

2013

Neuropsychiatry

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Effects of Motor Cortex Modulation and Descending Inhibitory Systems on Pain Thresholds in Healthy Subjects

Cited by 90 publications

References 57 publications

The Effect of Daily Self-Measurement of Pressure Pain Sensitivity Followed by Acupressure on Depression and Quality of Life versus Treatment as Usual in Ischemic Heart Disease: A Randomized Clinical Trial

The Effect of Daily Self-Measurement of Pressure Pain Sensitivity Followed by Acupressure on Depression and Quality of Life versus Treatment as Usual in Ischemic Heart Disease: A Randomized Clinical Trial

Conditioned Pain Modulation Predicts Exercise-Induced Hypoalgesia in Healthy Adults

Transcranial direct current stimulation: neurophysiology and clinical applications

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