Effects of mosapride on esophageal motor activity and esophagogastric junction compliance in healthy volunteers

Fukazawa, Kousuke; Furuta, K.; Adachi, Kyoichi; Moritou, Yoshiya; Saito, Tsukasa; Kusunoki, Ryusaku; Uno, Goichi; Shimura, Shino; Aimi, Masahito; Ohara, Shunji; Ishihara, Shunji; Kinoshita, Yoshikazu

doi:10.1007/s00535-013-0876-0

Cited by 25 publications

(53 citation statements)

References 40 publications

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“…In the present study, there was a tendency for mean LES pressure to increase following mosapride treatment, but the effect was not statistically significant. High‐dose mosapride has been reported to augment esophageal motor activities and reduce esophagogastric junction compliance in healthy volunteers . We suggest that, in this study, esophageal peristalsis may have provoked the hyperactive state without conditioning motility.…”

Section: Discussionmentioning

confidence: 53%

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Mosapride for gastroesophageal reflux disease in neurologically impaired patients

Komura

Kanamori

Tanaka

et al. 2016

Pediatrics International

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Section: Discussionmentioning

confidence: 53%

“…High-dose mosapride has been reported to augment esophageal motor activities and reduce esophagogastric junction compliance in healthy volunteers. 18 We suggest that, in this study, esophageal peristalsis may have provoked the hyperactive state without conditioning motility. High-dose mosapride may increase LES pressure significantly.…”

Section: Discussionmentioning

confidence: 54%

Mosapride for gastroesophageal reflux disease in neurologically impaired patients

Komura

Kanamori

Tanaka

et al. 2016

Pediatrics International

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“…As expected, the least distensible locus was the EGJ, whereas the region 6-10 cm above the EGJ had higher distensibility, and the region 2-5 cm above the EGJ had the highest distensibility [39]. Looking into possible treatment options for GERD, Fukazawa et al [40] found that mosapride given intravenously augmented peristaltic contractions, increased LES pressure, and decreased EGJ distensibility.…”

Section: Gastroesophageal Reflux Diseasementioning

confidence: 78%

Functional lumen imaging of the gastrointestinal tract

et al. 2015

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This nonsystematic review aims to describe recent developments in the use of functional lumen imaging in the gastrointestinal tract stimulated by the introduction of the functional lumen imaging probe. When ingested food in liquid and solid form is transported along the gastrointestinal tract, sphincters provide an important role in the flow and control of these contents. Inadequate function of sphincters is the basis of many gastrointestinal diseases. Despite this, traditional methods of sphincter diagnosis and measurement such as fluoroscopy, manometry, and the barostat are limited in what they can tell us. It has long been thought that measurement of sphincter function through resistance to distension is a better approach, now more commonly known as distensibility testing. The functional lumen imaging probe is the first medical measurement device that purports in a practical way to provide geometric profiling and measurement of distensibility in sphincters. With use of impedance planimetry, an axial series of cross-sectional areas and pressure in a cathetermounted allantoid bag are used for the calculation of distensibility parameters. The technique has been trialed in many valvular areas of the gastrointestinal tract, including the upper esophageal sphincter, the esophagogastric junction, and the anorectal region. It has shown potential in the biomechanical assessment of sphincter function and characterization of swallowing disorders, gastroesophageal reflux disease, eosinophilic esophagitis, achalasia, and fecal incontinence. From this early work, the functional lumen imaging technique has the potential to contribute to a better and more physiological understanding of narrowing regions in the gastrointestinal tract in general and sphincters in particular.

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“…The EGJ distensibility was found to be unchanged in patients with Barrett's esophagus after radiofrequency ablation . Another study indicated that the intravenous administration of mosapride enhanced esophageal peristaltic contractions, increased LES pressure, and reduced EGJ distensibility . Based on these studies, more prospective data with long‐term follow‐up are needed to further investigate the role of FLIP in GERD and subsequent targeted surgical and endoscopic fundoplication procedures.…”

Section: Flip For Gerdmentioning

confidence: 96%

Functional lumen imaging probe in gastrointestinal motility diseases

Chen

et al. 2019

J of Digest Diseases

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Dysfunction of gastrointestinal (GI) sphincters, including the lower esophageal sphincter (LES) at the esophagogastric junction (EGJ) and the pyloric sphincter, plays a vital role in GI motility disorders, such as achalasia, gastroesophageal reflux disease (GERD), gastroparesis, and fecal incontinence. Using multi‐detector high‐resolution impedance planimetry, the functional luminal imaging probe (FLIP) system measures simultaneous data on tissue distensibility and luminal geometry changes in the sphincter in a real‐time manner. In this review we focus on the emerging data on FLIP, which can be used as an innovative diagnostic method during endoscopic or surgical procedures in GI motility disorders. Subsequent large, prospective, standardizing studies are needed to validate these findings before it can be put to routine clinical use.

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Effects of mosapride on esophageal motor activity and esophagogastric junction compliance in healthy volunteers

Abstract: Mosapride at 40 mg augmented esophageal motor activities and reduced EGJ compliance in healthy volunteers.

Cited by 25 publications

References 40 publications

Mosapride for gastroesophageal reflux disease in neurologically impaired patients

Mosapride for gastroesophageal reflux disease in neurologically impaired patients

Functional lumen imaging of the gastrointestinal tract

Functional lumen imaging probe in gastrointestinal motility diseases

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