2020
DOI: 10.1590/1678-9199-jvatitd-2019-0041 View full text |Buy / Rent full text
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Abstract: Background: Here, we described the presence of a neurotoxin with phospholipase A 2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs). Methods: The purification, molecular mass determination, partial amino acid sequencing, phospholipase A 2 activity determination, inhibition of the binding of the selective muscarinic ligand [ 3 H]QNB and inhibition of the total [ 3 H]inositol phosphate accumulation in rat hippocampus of the Mlx-8 were determi… Show more

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“…The neuromuscular blockade is the hallmark of the Micrurus envenomation [ 14 , 21 , 22 , 24 , 25 , 26 ] and the two most abundant neurotoxin families are the main ones responsible for this outcome. Diverse types of presynaptically active PLA 2 can act by blocking the release of acetylcholine (ACh) [ 27 , 28 , 29 , 30 ], and different types of postsynaptic 3FTxs can act by blocking the nicotinic acetylcholine receptors (nAChRs) [ 31 ], leading to neuromuscular paralysis. Beyond the classical activities, the exploration of 3FTxs and PLA 2 s from diverse Elapids around the globe (e.g., coral snakes, Najas, Bungarus, Mambas, etc.)…”
Section: Introductionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…The neuromuscular blockade is the hallmark of the Micrurus envenomation [ 14 , 21 , 22 , 24 , 25 , 26 ] and the two most abundant neurotoxin families are the main ones responsible for this outcome. Diverse types of presynaptically active PLA 2 can act by blocking the release of acetylcholine (ACh) [ 27 , 28 , 29 , 30 ], and different types of postsynaptic 3FTxs can act by blocking the nicotinic acetylcholine receptors (nAChRs) [ 31 ], leading to neuromuscular paralysis. Beyond the classical activities, the exploration of 3FTxs and PLA 2 s from diverse Elapids around the globe (e.g., coral snakes, Najas, Bungarus, Mambas, etc.)…”
Section: Introductionmentioning
“…ação inflamatória e edematogênica [90,91], hemólise [92,93], ação anticoagulante [90,91], modulação de receptores muscarínicos [94], e bloqueio neuromuscular [50,95]. Entretanto, com relação a última atividade, pouco se tem investigado da neurotoxicidade destas enzimas, e a proporção de PLA 2 que representa neurotoxinas é desconhecida para a grande maioria destas peçonhas (embora toda -neurotoxina seja uma PLA 2 , o contrário não é verídico).…”
Section: As β-Neurotoxinasunclassified
“…browni browni [77], M. fulvius [87], M. carvalhoi [94,96,97] e M. spixii [95], mas ainda não foram bem caracterizadas quanto ao seu mecanismo de ação, isto é, uma demonstração clara de uma ação pré-sináptica.…”
Section: As β-Neurotoxinasunclassified