Effects of misoprostol on cisplatin-induced renal damage in rats

Özer, Mehmet Kaya; Aşçı, Halil; Öncü, Meral; Calapoğlu, Mustafa; Savran, Mehtap; Yeşilot, Şükriye; Candan, İbrahim Aydın; Çiçek, Ekrem

doi:10.1016/j.fct.2011.03.051

Cited by 17 publications

(12 citation statements)

References 20 publications

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“…In agreement with the results of present study, Abdelmeguid et al [18]; Azu et al [19]; Ozer et al [6] reported that the light microscopy of CP-treated rats renal sections revealed marked tubular degeneration, necrosis and desquamation of the tubular epithelial cells with cystic formation, interstitial cellular infiltration, wide capsular space and congested glomerular capillary tufts. The authors added that the oxidative stress was the major pathway of CP nephrotoxicity.…”

Section: Discussionsupporting

confidence: 93%

“…Several antioxidants have been used to protect against the deleterious effects of CP on the kidney [4,6,5]. Misoprostol (MP) is a synthetic methylene prostaglandin E1 (PGE1) analogue that is used in the treatment of peptic ulcer [7].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, MP has antiapoptotic and cytoprotective effects as well [9,10]. The effect of MP on CP-induced changes in lipid peroxidation and antioxidant enzymes in rat kidney has been investigated [6]. However, no study was done to clarify the possible protective effect of MP on the CP-induced changes at the ultrastructural level in rat kidney.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Misoprostol on Ultrastructural Changes of Renal Tissues in Cisplatin-Treated Adult Rats

Nasr¹

2013

J Cytol Histol

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Background: Cisplatin (CP) is one of the most effective antineoplastic drugs used for the treatment of various solid tumors. However, the nephrotoxic effect of CP limits its clinical use. The present study aimed to evaluate the possible protective effect of misoprostol (MP) against cisplatin-induced nephrotoxicity. Material & Methods: Twenty four male rats were randomly divided into four equal groups (control, cisplatintreated, misoprostol-treated and combined misoprostol and cisplatin-treated). Group II rats were treated with CP single i.p. dose of 7.5mg/kg on 5 th day. Group III Rats were treated with oral MP at a dose of 200µg/kg/day for nine days. Group II rats were treated with CP single i.p. dose of 7.5mg/kg day MP for nine consecutive days and injected with CP single i.p. dose (7.5mg/kg) on 5 th day. Body weight of rats was recorded on 1 st , 3 rd , 5 th , 7 th and 9 th. days. On the 10 th day, the rats were anesthetized by ether and scarified. Blood samples were obtained to determine creatinine and BUN levels. Body weight, Kidney weight & body weight/kidney weight ratio were calculated. Specimens of rats' kidneys were prepared for both light and electron microscopic examinations. Results: single dose of CP (7.5 mg/kg i.p) resulted in a significant decrease of body weight (P.˂0.001), decrease of kidney weight (P.˂0.005), increase of relative kidney weight/body weight ratio (P.˂0.005) and increase of creatinine and BUN levels (P.˂0.001) compared to control rats. Combination of MP with CP improved most of the previous parameters. In CP-treated rats, marked degenerative and necrotic changes were noticed at the cortico-medullary renal zone. In combined MP and CP-treated rats, mild degenerative changes were seen within the renal tissues. Conclusion: The present study may provide promising results about the protective effect of MP against CPinduced nephrotoxicity that may be of value in tumor therapy programs.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Misoprostol on Ultrastructural Changes of Renal Tissues in Cisplatin-Treated Adult Rats

Nasr¹

2013

J Cytol Histol

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“…Recently, a large number of studies have described the beneficial effects and promising roles of a variety of natural diet antioxidants in protecting the kidney against CDDP-induced nephrotoxicity. Therefore, to increase the clinical efficacy of CDDP, without inhibiting its anti-tumor effects, different experimental studies were carried out using a combination of CDDP with a variety of radicular scavengers, enzyme inhibitors, sulfur-containing antioxidants and natural foods with antioxidant properties to ameliorate CDDP-induced nephrotoxicity (Saad et al, 2009;Abdelmeguid et al, 2010;Ozer et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Effect of Silymarin on Cisplatin-Induced Renal Oxidative Stress in Rats

Abouzeinab¹

2014

J. of Pharmacology and Toxicology

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Silymarin (SIL) is a natural occurring antioxidant and has a free radical scavenging property. Cisplatin (CDDP) is a chemotherapeutic agent associated with nephrotoxicity. This study aims at investigating the antioxidant effect of SIL against CDDP-induced oxidative stress and renal toxicity in rat kidney. Thirty rats were divided into 5 groups of 6 animals each. The first group (G1) received no chemical treatment, G2 injected with 0.15 mL vehicle (propylene glycol and saline) intraperitoneally (i.p.), G3 injected with a single dose of CDDP 5 mg kgG 1 , i.p. only at the first day, G4 received SIL (50 mg kgG 1 dayG 1 , i.p.) 2 h after a single dose of CDDP (5 mg kgG 1 ; i.p.) and G5 received SIL (50 mg kgG 1 dayG 1 , i.p.) 2 h before a single dose of CDDP (5 mg kgG 1 ; i.p.). On day fifteen, animals sacrificed, serum and/or kidney tissues were used to determine renal functional markers (serum urea, creatinine), oxidative stress index (lipid peroxidation: Malondialdehyde), antioxidant enzyme activities (superoxide dismutase, SOD; glutathione peroxidase, GPx) and light microscopical analysis. The CDDP-induced oxidative stress was indicated by a marked increase in: Serum urea and creatinine concentration and tissue MDA and a significant reduction in SOD and GPx activities. The CDDP also caused severe histopahtological changes and histochemical depletion of total protein contents in kidney cells. Results suggest that pretreatment with SIL protect kidney tissues fully against CDDP toxicity, since renal markers, MDA levels; activities of antioxidant enzymes, histological and histochemical features were restored to normal levels. Hence, SIL could be a promising nephroprotective and antioxidant agent for reducing CDDP-induced renal oxidative stress and toxicity.

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“…Attia (2012) demontrated that resveratrol has a protective role in CDDP-induced genotoxicity and apoptosis in somatic and germ cells of mice. Also, Ozer et al (2011) have shown that misoprostol treatment after CDDP application protected the renal tissues from CDDP's side effect. Atessahin et al (2006) have investigated histological examinations in testes and further indicated significant damage to Sertoli, Leydig and germ cell populations induced by CDDP.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of bilberry (Vaccinium myrtillus L.) on cisplatin induced ovarian damage in rat

Pandır

Kara

2013

Cytotechnology

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Cisplatin is one of the most effective chemotherapeutic agents but injury may occur at higher doses. The aim of this study was to investigate the effect of bilberry on cisplatin induced toxic effects in rat ovary. Twenty-one female Wistar-Albino rats were utilized to form three groups: In group 1 (control group), each rat received intraperitoneal injection of 1 mL of 0.9 % NaCl saline solution during 10

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Effects of misoprostol on cisplatin-induced renal damage in rats

Cited by 17 publications

References 20 publications

Effect of Misoprostol on Ultrastructural Changes of Renal Tissues in Cisplatin-Treated Adult Rats

Effect of Misoprostol on Ultrastructural Changes of Renal Tissues in Cisplatin-Treated Adult Rats

Antioxidant Effect of Silymarin on Cisplatin-Induced Renal Oxidative Stress in Rats

Protective effect of bilberry (Vaccinium myrtillus L.) on cisplatin induced ovarian damage in rat

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