Effects of miR-29a and miR-101a Expression on Myocardial Interstitial Collagen Generation After Aerobic Exercise in Myocardial-infarcted Rats

Li, Xiao; He, Huimin; Ma, Lele; Da, Miaomiao; Cheng, Sinan; Duan, Yan; Wang, Qian; Wu, Huayi; Song, Xigui; Duan, Wei; Tian, Zhenjun; Hou, Yingchun

doi:10.1016/j.arcmed.2017.01.006

Cited by 34 publications

(24 citation statements)

References 30 publications

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“…The related genes are listed in Appendix . Recent progress has demonstrated that miRNAs might play a critical role in exercise‐mediated beneficial regulation in MI . Therefore, we also applied IPA to analyse the differential expression of 87 miRNAs in the infarct zone between early moderate exercise MI hearts and sedentary MI hearts.…”

Section: Resultsmentioning

confidence: 99%

“…Recent progress has demonstrated that miR-NAs might play a critical role in exercise-mediated beneficial regulation in MI. 36 Therefore, we also applied IPA to analyse the differential expression of 87 miRNAs in the infarct zone between early moderate exercise MI hearts and sedentary MI hearts. IPA showed that, at the miRNA level, no predicted activation or inhibition effects regarding the canonical pathway, upstream signalling, or molecular and physiological function were identified (z-score < 2).…”

Section: Mirna-mrna Integrative Ipa Reveals That the Inhibition Of mentioning

confidence: 99%

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Early moderate exercise benefits myocardial infarction healing via improvement of inflammation and ventricular remodelling in rats

Liao

Chen

et al. 2019

J Cellular Molecular Medi

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Thus far, the cellular and molecular mechanisms related to early (especially within 24 hours after acute myocardial infarct (MI)) exercise‐mediated beneficial effects on MI have not yet been thoroughly established. In the present study, we demonstrated that acute MI rats that underwent early moderate exercise training beginning one day after MI showed no increase in mortality and displayed significant improvements in MI healing and ventricular remodelling, including an improvement in cardiac function, a decrease in infarct size, cardiomyocyte apoptosis, cardiac fibrosis and cardiomyocyte hypertrophy, and an increase in myocardial angiogenesis, left ventricular wall thickness and the number of cardiac telocytes in the border zone. Integrated miRNA‐mRNA profiling analysis performed by the ingenuity pathway analysis system revealed that the inhibition of the TGFB1 regulatory network, activation of leucocytes and migration of leucocytes into the infarct zone comprise the molecular mechanism underlying early moderate exercise‐mediated improvements in cardiac fibrosis and the pathological inflammatory response. The findings of the present study demonstrate that early moderate exercise training beginning one day after MI is safe and leads to significantly enhanced MI healing and ventricular remodelling. Understanding the mechanism behind the positive effects of this early training protocol will help us to further tailor suitable cardiac rehabilitation programmes for humans.

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Section: Resultsmentioning

confidence: 99%

Section: Mirna-mrna Integrative Ipa Reveals That the Inhibition Of mentioning

confidence: 99%

Early moderate exercise benefits myocardial infarction healing via improvement of inflammation and ventricular remodelling in rats

Liao

Chen

et al. 2019

J Cellular Molecular Medi

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“…A recent report indicated that miR-101 inhibits fibrosis and thus may help preserve left ventricle function after myocardial infarction [39] Xiao et al also reported that upregulation of miR-101a leads reduced fibrosis and scar formation in cardiac tissue from rats with myocardial infarction [40]. Inhibition of miR-101 was shown to attenuate hypoxia/ reoxygenation-induced apoptosis through induction of autophagy in H9C2 cardiomyocytes [41].…”

Section: Discussionmentioning

confidence: 98%

Circulating miRNA Expression Profiling and Target Prediction in Patients Receiving Dexmedetomidine

Yang

Chen

et al. 2018

Cell Physiol Biochem

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Background/Aims: Circulating miRNAs could serve as biomarkers for diagnosis or prognosis of heart diseases and cerebrovascular diseases. Dexmedetomidine has protective effects in various organs. The effects of dexmedetomidine on circulating miRNAs remain unknown. Here, we investigated differentially expressed miRNA and to predict the target genes of the miRNA in patients receiving dexmedetomidine. Methods: The expression levels of circulating miRNAs of 3 patients were determined through high through-put miRNA sequencing technology. Target genes of the identified differentially expressed miRNAs were predicted using TargetScan 7.1 and miRDB v.5. Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to conduct functional annotation and pathway enrichment analysis of target genes respectively. Results: Twelve differentially expressed miRNAs were identified. Five miRNAs were upregulated (hsa-miR-4508, hsa-miR-novel-chr8_87373, hsa-miR-30a-3p, hsa-miR-novel-chr16_26099, hsa-miR-4306) and seven miRNAs (hsa-miR-744-5p, hsa-miR-320a, hsa-miR-novel-chr9_90035, hsa-miR-101-3p, hsa-miR-150-5p, hsa-miR-342-3p, and hsa-miR-140-3p) were downregulated after administration of dexmedetomidine in the subjects. The target genes and pathways related to the differentially expressed miRNAs were predicted and analyzed. Conclusion: The differentially expressed miRNAs may be involved in the mechanisms of action of dexmedetomidine. Specific miRNAs, such as hsa-miR-101-3p, hsa-miR-150-5p and hsa-miR-140-3p, are new potential targets for further functional studies of dexmedetomidine.

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“…MiR-17-3p was also reported to play a positive role in the ET-induced effects, and the elevation of miR-17-3p could contribute to ET-induced cardiac growth and protect cardiac ischemia/reperfusion mice models from adverse ventricular remodeling [32]. Li et al showed that aerobic exercise could evidently attenuate the myocardial interstitial fibrosis induced by MI by inhibiting the transforming growth factor beta 1 (TGFb-1) pathways by up-regulating the expressions of miR-29a and miR-101a [33]. These findings demonstrated the important roles of miRNAs in the positive effects of ET on improving MI and ventricular remodeling.…”

Section: Discussionmentioning

confidence: 99%

Inhibiting MicroRNA-497 Improves the Effects of Exercise Training on Myocardial Infarction

Pan

et al. 2020

Int J Sports Med

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Exercise training (ET) could improve myocardial infarction (MI), and microRNA-497 is highly associated with MI. This study aimed to investigate whether the regulation of miR-497 is involved in the positive effects of ET on MI. MI rat models induced by left anterior descending (LAD) were subjected to interval training and infarct size was observed. Blood and myocardial samples were collected from the rats for determining the expressions of miR-497. To evaluate the functions of miR-497, miR-497 agomir and antagomir were injected accordingly into grouped rats during ET, and subsequently, the expressions of apoptotic and inflammatory factors were determined. ET reduced the infarct size in MI rats and inhibited the levels of miR-497. MiR-497 agomir injection enlarged the infarct size, and reversed the shrunk infarct size induced by ET. However, miR-497 antagomir further promoted the positive effect on MI improved by ET. Chloride voltage-gated channel 3 (CLCN3) was identified as the most possible target for miR-497. Moreover, ET improving MI also involved the regulation of apoptotic and inflammatory factors. The mechanisms underlying the positive effects of ET on MI were highly associated with the regulation of miR-497.

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Effects of miR-29a and miR-101a Expression on Myocardial Interstitial Collagen Generation After Aerobic Exercise in Myocardial-infarcted Rats

Cited by 34 publications

References 30 publications

Early moderate exercise benefits myocardial infarction healing via improvement of inflammation and ventricular remodelling in rats

Early moderate exercise benefits myocardial infarction healing via improvement of inflammation and ventricular remodelling in rats

Circulating miRNA Expression Profiling and Target Prediction in Patients Receiving Dexmedetomidine

Inhibiting MicroRNA-497 Improves the Effects of Exercise Training on Myocardial Infarction

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