1960
DOI: 10.1001/archderm.1960.01580050104016
|View full text |Cite
|
Sign up to set email alerts
|

Effects of Methotrexate on Basal-Cell Carcinomas

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
7
0

Year Published

1961
1961
1989
1989

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 36 publications
(7 citation statements)
references
References 10 publications
0
7
0
Order By: Relevance
“…The highest value ofVan Scott et al reported abnormal BSP findings in two patients given methotrexate I.V. for multiple basal cell epitheliomas 22. We find few changes in liver function test readings, perhaps because determinations were done just prior to readministration of the drug, allowing possible abnormal reading times to return to normal.1 Wright et al found some abnormal liver function in ten patients given 25 to 50 mg of methotrexate intramuscularly (I.M.)…”
mentioning
confidence: 54%
“…The highest value ofVan Scott et al reported abnormal BSP findings in two patients given methotrexate I.V. for multiple basal cell epitheliomas 22. We find few changes in liver function test readings, perhaps because determinations were done just prior to readministration of the drug, allowing possible abnormal reading times to return to normal.1 Wright et al found some abnormal liver function in ten patients given 25 to 50 mg of methotrexate intramuscularly (I.M.)…”
mentioning
confidence: 54%
“…We suspect that epidermal DNA synthesis in humans is not directly sensitive to methotrexate, and that DNA synthesis in the de novo pathway is probably not concerned with it. In fact, methotrexate has no or little effect on basal cell carcinoma (14); it seems that a malignancy derived from epidermis is not very sensitive to this compound. This aspect of epidermal DNA synthesis in relationship to methotrexate metabolism should become clearer in the future if our viewpoint is correct.…”
Section: Discussionmentioning
confidence: 99%
“…After injection, methotrexate accumulates in erythrocytes with none remaining at 24 hrs later; about 90% is excreted in urine (13). In mice, methotrexate accumulates in erythrocytes, intestine, liver, and bone marrow after subcutaneous (23) and intravenous administration (14) and disappears 24 hrs later via urine excretion. Accumulation in epidermis as methotrexate polyglutamate was found in rat skin (15).…”
Section: Discussionmentioning
confidence: 99%
“…See also ISToguchi et al (1960). vi-;:*^ •/ ;;;:>;--; (4) Van Scott et al (1960) employed methotrexate systemically in seven, patients with multiple rodent carcinomas. This caused marked histological and clinical damage in lesions with complete disappearance of some.…”
Section: Ghemotherapeutic Methodsmentioning
confidence: 99%