2002
DOI: 10.1007/s00213-002-1081-7
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Abstract: We suggested that melatonin attenuates both reserpine- and age-induced OM in rats.

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Cited by 44 publications
(5 citation statements)
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“…Reserpine also increased rats’ catalepsy behavior and decreased their locomotor activity – motor impairments used to model symptoms of Parkinson’s disease ( Leao et al, 2015 ). These effects are in accordance with previous reports ( Abilio et al, 2002 , 2004 ; Silva et al, 2002 ; Carvalho et al, 2006 ; Fernandes et al, 2012 ; Santos et al, 2013 ; Leao et al, 2015 ; Nade et al, 2015 ; de Freitas et al, 2016 ).…”
Section: Discussionsupporting
confidence: 94%
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“…Reserpine also increased rats’ catalepsy behavior and decreased their locomotor activity – motor impairments used to model symptoms of Parkinson’s disease ( Leao et al, 2015 ). These effects are in accordance with previous reports ( Abilio et al, 2002 , 2004 ; Silva et al, 2002 ; Carvalho et al, 2006 ; Fernandes et al, 2012 ; Santos et al, 2013 ; Leao et al, 2015 ; Nade et al, 2015 ; de Freitas et al, 2016 ).…”
Section: Discussionsupporting
confidence: 94%
“…However, as mentioned, oxidative stress is linked to the reserpine effects, to Parkinson’s disease and tardive dyskinesia. Previous data from our group show that the effects of reserpine are potentiated by a pro-oxidant compound ( Calvente et al, 2002 ) and attenuated by the free radical scavengers vitamin C, vitamin E, and melatonin ( Abilio et al, 2002 , 2003a ; Faria et al, 2005 ). In accordance, CBD has been described to present antioxidant, anti-inflammatory, and neuroprotective actions.…”
Section: Discussionmentioning
confidence: 91%
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“…The treatment with melatonin (Melapure™ kindly provided by Flamma S.p.A., Chignolo d’Isola, Italy), in combination or not with reserpine, was administered in two different dosages and three different duration of treatments: melatonin was administrated orally for three days (simultaneously to the treatment of reserpine), or for one month or for two months at a final dose of 2.5 mg/kg body weight for day [ 67 ] or at a final dose of 5 mg/kg body weight for day [ 68 ]. Powdered pure melatonin was given after being dissolved in 1% of ethanol and then in drinking tap water.…”
Section: Methodsmentioning
confidence: 99%