Effects of maternally exposed coloring food additives on receptor expressions related to learning and memory in rats

Ceyhan, Betül Mermi; Gültekin, Fatih; Doğuç, Duygu Kumbul; Kulaç, Esin

doi:10.1016/j.fct.2013.02.016

Cited by 48 publications

(30 citation statements)

References 25 publications

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“…Sunset yellow (E110) has also been reported to produce adverse effects in people especially children (Yadav et al, 2013) and has been regulated in most countries. The other artificial colours Allura red (129), amaranth (E123) and ponceau (E124) have also been reported to have adverse effects in several studies (Ceyhan et al, 2013). The only natural colour found to be potentially harmful among the sampled products was annatto extracts (E160 b), which was found in one of the spices.…”

Section: Potentially Harmful Artificial and Natural Colours Found In mentioning

confidence: 98%

“…The Joint FAO/WHO Expert Committee on Food Additives (JECFA) regulates food additives globally but individual countries have specific regulations, which are enforced by their food regulating bodies. There are several controversies surrounding the use of certain food additives and the acceptable daily intake (McCann et al, 2007;Bosetti et al, 2009;El-Wahab and Moram, 2013;Ceyhan et al, 2013;Abhilash et al, 2014;Masone and Chanforan, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Proliferation of Illegal and Potentially Hazardous Food Additives in Processed and Packaged Foods in Africa: A Case Study and Hazard Identification in Ghana

Setsoafia¹

2015

J. of Food Resource Science

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In the developed countries, a lot of researches have been carried out on the effects of food additives on consumers but few studies have been reported in Africa and particularly Ghana. The objective of the study was to survey labels of processed and packaged foods in Ghana and document all the potentially harmful food additives in processed and packaged foods in some Ghanaian food products. We purchased 63 processed and packaged food products from the Ghanaian market and documented food additives on their labels as well as trade name, type of food, company name, country of origin and whether the Ghana Food and Drugs Authority (GFDA) certified them. Thirty seven percent of all the products sampled on the market were not registered with the GFDA. Seventy one percent of all the products sampled contained one or more additives that are likely to cause adverse reactions when consumed. The general public is at risk of consuming potentially hazardous food additives. There is the need for a research to determine whether the levels of additives are above the recommended acceptable daily intake proposed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA).

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Section: Potentially Harmful Artificial and Natural Colours Found In mentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Proliferation of Illegal and Potentially Hazardous Food Additives in Processed and Packaged Foods in Africa: A Case Study and Hazard Identification in Ghana

Setsoafia¹

2015

J. of Food Resource Science

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“…In the study by Ceyhan et al (2013), a mixture of authorised food colours (Sunset Yellow FCF, 2.5 mg/kg bw, Allura Red, 7 mg/kg bw/day, Erythrosin, 0.1 mg/kg bw/day, Ponceau 4R, 4 mg/kg bw/day, Tartrazine, 7.5 mg/kg bw/day, Amaranth, 0.5 mg/kg bw/day, Brilliant Blue 12.5 mg/kg bw/day, Azorubine, 4 mg/kg bw/day and Indigotine 5 mg/kg bw/day, purity of the test material not known) was administered to female rats one week before mating, during mating and during the gestation period at doses corresponding to the respective ADIs. The effects of intrauterine exposure of synthetic food colours on expression of N-methyl-D-aspartate receptors (NMDARs) subunits (NR2A and NR2B) and nicotinic acetylcholine receptors (nAChRs) subunits α7, α4, ß2 were investigated in their offspring when they became adults.…”

Section: Neurodevelopmental Toxicity and Neurobehavioural Studiesmentioning

confidence: 98%

“…Some studies by the same research group aimed at investigating neurodevelopmental toxicity and conducted with mixtures of food additives, locally sourced and of unknown purity, were retrieved (Ceyhan et al, 2013;Doguc et al, 2013aDoguc et al, , 2013b). …”

Section: Neurodevelopmental Toxicity and Neurobehavioural Studiesmentioning

confidence: 99%

Reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E 110)

Panel¹

2014

EFSA Journal

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The Panel on Food Additives and Nutrient Sources added to Food (ANS Panel) has previously provided a scientific opinion re-evaluating the safety of Sunset Yellow FCF (E 110) as a food additive in the EU and establishing a temporary acceptable daily intake (ADI) of 1 mg/kg bw/day (EFSA ANS Panel, 2009). Following a request by the European Commission, the ANS Panel was asked to assess newly submitted data from a study conducted as a result of the recommendations contained in the 2009 opinion. In addition, EFSA was requested to carry out the refined exposure assessment of Sunset Yellow FCF. The new information assessed comprised an evaluation of the 28-day study report, the data considered by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in its latest evaluation from 2011, and any additional toxicological information that had become available since the completion of the previous evaluation by the ANS Panel. The ANS Panel has considered that the newly submitted data from the 28-day study and the overall available toxicological database on Sunset Yellow FCF provides a basis to revise the established temporary ADI and concluded that, based on the NOAEL of 375 mg/kg bw/day from the long-term feeding study in rats and an uncertainty factor of 100, a new ADI for Sunset Yellow FCF of 4 mg/kg bw/day can be established, in agreement with the latest evaluation by JECFA. Exposure estimates for Sunset Yellow FCF based both on the currently authorised MPLs and reported use levels provided are well below the new ADI of 4 mg/kg bw/day for all population groups. Overall, the Panel concluded that, using data provided by the food industry and Member States, the reported uses and use levels of Sunset Yellow FCF (E 110) would not be of safety concern. © European Food SUMMARYIn 2009 the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS Panel) has adopted a scientific opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive in the EU. In its opinion, the ANS Panel established a temporary acceptable daily intake (tADI) of 1 mg/kg bw/day and requested a 28-day study with Sunset Yellow FCF to be performed in accordance with OECD guidelines and with well-defined material, in order to clarify the histopathological changes in the testes and the changes in the blood lipid profile observed by Mathur el al. (2005aMathur el al. ( , 2005b in rats, after 90-day dietary exposure to Sunset Yellow FCF at dose levels equivalent to 250 and 1 500 mg/kg bw/day.Following a request from the European Commission, the ANS Panel was asked to deliver a scientific opinion on the data generated from a 28-day study conducted as a result of the recommendations contained in the 2009 opinion and whether, on the grounds of these new data, the ADI should be reconsidered.Furthermore, following the conclusions of the 2009 opinion as regards exposure to Sunset Yellow FCF (E 110), EFSA was requested to carry out a refined exposure assessment for this food additive. In that opinion, the ANS Panel had evaluated t...

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“…Generally, most food dyes widely used in China and abroad are synthetic azo dyes, and they are applied in fields such as foodstuffs, drugs and cosmetics [4] due to their high brightness and wide color spectrum. However, the excessive and long-term consumption of these dyes is very harmful to human health, particularly when the excessive usage causes food safety issues [5,6,7]. As the common edible colorant, sunset yellow (SY) and allura red (AR) have strong genetic toxicity [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

A Novel Preparation Method of Two Polymer Dyes with Low Cytotoxicity

Zhang

Cui

et al. 2017

Materials

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A new preparation method of polymer dyes was developed to improve both the grafting degree of the azo dyes onto O-carboxymethyl chitosan (OMCS) and the water solubility of prepared polymer dyes. Firstly, the coupling compound of two azo edible colorants, sunset yellow (SY) and allura red (AR), was grafted onto OMCS, and then coupled with their diazonium salt. The chemical structure of prepared polymer dyes was determined by Fourier transform-infrared spectroscopy and 1H-NMR, and the results showed that the two azo dyes were successfully grafted onto OMCS. The grafting degree onto OMCS and the water solubility of polymer dyes were tested, and the results showed that they were both improved as expected. The UV-vis spectra analysis results showed that the prepared polymer dyes showed similar color performance with the original azo dyes. Eventually, the cytotoxicity of prepared polymer dyes was tested and compared with the original azo dyes by a cytotoxicity test on human liver cell lines LO2, and the results showed that their grafting onto OMCS significantly reduced the cytotoxicity.

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Effects of maternally exposed coloring food additives on receptor expressions related to learning and memory in rats

Cited by 48 publications

References 25 publications

Proliferation of Illegal and Potentially Hazardous Food Additives in Processed and Packaged Foods in Africa: A Case Study and Hazard Identification in Ghana

Proliferation of Illegal and Potentially Hazardous Food Additives in Processed and Packaged Foods in Africa: A Case Study and Hazard Identification in Ghana

Reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E 110)

A Novel Preparation Method of Two Polymer Dyes with Low Cytotoxicity

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