J. Neurosci. Res. volume 87, issue 1, P179-189 2009 DOI: 10.1002/jnr.21825 View full text
Shadi N. Malaeb, Virginia Hovanesian, Matthew D. Sarasin, Silvia M. Hartmann, Grazyna B. Sadowska, Barbara S. Stonestreet

Abstract: AbstractWe examined the effects of single and multiple maternal glucocorticoid courses on apoptosis in the cerebral cortices of ovine fetuses (CC). Ewes received single dexamethasone or placebo courses at 104-106 or 133-135 days or multiple courses between 76-78 and 104-106 days gestation. In the single-course groups, ewes received four 6 mg dexamethasone or placebo injections every 12 hr for 48 hr. Multiple-course groups received the same treatment once per week for 5 weeks. Neuronal and nonneuronal apoptoti…

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