Shadi N. Malaeb, Virginia Hovanesian, Matthew D. Sarasin, Silvia M. Hartmann, Grazyna B. Sadowska, Barbara S. Stonestreet
AbstractWe examined the effects of single and multiple maternal glucocorticoid courses on apoptosis in the cerebral cortices of ovine fetuses (CC). Ewes received single dexamethasone or placebo courses at 104-106 or 133-135 days or multiple courses between 76-78 and 104-106 days gestation. In the single-course groups, ewes received four 6 mg dexamethasone or placebo injections every 12 hr for 48 hr. Multiple-course groups received the same treatment once per week for 5 weeks. Neuronal and nonneuronal apoptoti…
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