Effects of maternal and paternal alcohol consumption on the success rates of in vitro fertilization and gamete intrafallopian transfer

Klonoff-Cohen, Hillary; Lam-Kruglick, Phung; González, Cristina González

doi:10.1016/s0015-0282(02)04582-x

Cited by 126 publications

(89 citation statements)

References 24 publications

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“…The risk of not achieving a live birth increased by 2.28 (1.08-4.80) to 8.32 (1.82-37.97) times, depending on the time period, in men who drank one additional drink per day; drinking beer also affected live births (odds ratio55.49-45.64). 37 Alcohol consumption during pregnancy: effects on male offspring sperm parameters The effects, if any, of maternal alcohol consumption during pregnancy and sperm parameters and reproductive hormone levels were evaluated in the sons of these women. From a cohort of Danish pregnant women established in 1984-1987, 347 young adult sons were selected for a follow-up study conducted in [2005][2006].…”

Section: Alcohol Consumption and Couple's Fertilitymentioning

confidence: 99%

Does alcohol have any effect on male reproductive function? A review of literature

Vignera¹,

Condorelli²,

Balercia³

et al. 2012

Asian J Androl

146

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Although alcohol is widely used, its impact on the male reproductive function is still controversial. Over the years, many studies have investigated the effects of alcohol consumption on sperm parameters and male infertility. This article reviews the main preclinical and clinical evidences. Studies conducted on the experimental animal have shown that a diet enriched with ethanol causes sperm parameter abnormalities, a number of alterations involving the reproductive tract inhibition, and reduced mouse oocyte in vitro fertilization rate. These effects were partly reversible upon discontinuation of alcohol consumption. Most of the studies evaluating the effects of alcohol in men have shown a negative impact on the sperm parameters. This has been reported to be associated with hypotestosteronemia and low-normal or elevated gonadotropin levels suggesting a combined central and testicular detrimental effect of alcohol. Nevertheless, alcohol consumption does not seem to have much effect on fertility either in in vitro fertilization programs or population-based studies. Finally, the genetic background and other concomitant, alcohol consumption-related conditions influence the degree of the testicular damage. In conclusion, alcohol consumption is associated with a deterioration of sperm parameters which may be partially reversible upon alcohol consumption discontinuation.

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Section: Alcohol Consumption and Couple's Fertilitymentioning

confidence: 99%

Does alcohol have any effect on male reproductive function? A review of literature

Vignera¹,

Condorelli²,

Balercia³

et al. 2012

Asian J Androl

146

View full text Add to dashboard Cite

show abstract

“…The strongest evidence suggesting harm comes from a prospective cohort study of 2,545 couples undergoing their fi rst IVF cycle which found that women who drink at least four drinks per week had a 16 % lower likelihood of a live birth compared with those who consume alcohol less often [ 263 ]. Although similar fi ndings have been reported by others [ 264 ], an analysis of this association in the randomized trial of IUI mentioned above revealed a similar pattern to the fi ndings for caffeine [ 262 ]. Discontinuing alcohol was associated with a higher likelihood of live birth, relative to women who never consumed alcohol.…”

Section: Diet and Fertility Treatment Outcomesmentioning

confidence: 60%

Nutrition in Human Fertility

Chavarro

Cardozo

Afeiche

2015

Obesity and Fertility

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Identifying the extent to which modifi able lifestyle factors infl uence human fertility is of major clinical and public health signifi cance. It is estimated that more than fi ve million children have been born worldwide as a result of assisted reproduction [ 1 ]. In 2010 alone, there were nearly 150,000 assisted reproduction cycles resulting in more than 47,000 deliveries and the birth of 61,564 children in the United States [ 2 ]. These impressive fi gures notwithstanding, the number of subfertile couples benefi ting from these therapies represents approximately one tenth of those estimated to meet the clinical defi nition of infertility and about 2 % of women estimated to be unable to get pregnant or carry a pregnancy to term nationwide [ 3 ]. This vast gap alone highlights the need to identify strategies to address infertility that do not rely solely on clinical interventions and can be implemented on a population-wide level.On the other hand, there is a critical need to further improve success rates of infertility treatments. While the proportion of live births per initiated assisted reproduction cycle in the United States improved gradually through the 1990s, it has remained steady, at about 30 %, for almost a decade (Fig. 4.1 ). Unfortunately, very few predictors of successful infertility treatment are known and the strongest and best-characterized risk factor for unsuccessful infertility treatment, age [ 4 , 5 ], is not modifi able. Moreover, the proportion of women delaying childbearing into their 30s and beyond 35 years has increased dramatically in the United States and other Western nations [ 6 ]. These facts highlight the need to identify potentially modifiable factors associated with fertility treatment outcomes. Emerging evidence further suggests that diet, a potentially modifi able factor, could have a major impact on human fertility independent of body weight. In this chapter we will review and summarize the current evidence linking diet to fertility in women and men, and to outcomes of infertility treatment. Diet and Female FertilityInterest in the role of diet on female fertility is longstanding. There are reports of animal models evaluating the effects of micronutrient defi ciencies on ovulatory function as early as the 1960s [ 7 ] and prospective studies in humans evaluating the role of other dietary factors on fertility since the 1980s [ 8 ]. Most of the existing literature revolves around the potential role of two purported reproductive toxicants on fertility, caffeine, and alcohol, and is plagued with poor quality research. Recent fi ndings, however, suggests that the role of diet on human fertility and on conditions associated with infertility may be much broader. Most of the interest in evaluating the role of caffeine on reproductive performance in general and on fertility in particular can be traced back to a series of experiments in rodents which documented an increased frequency of fetal resorption and congenital malformations of the skeleton in rats receiving caffeine via oral intub...

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“…Although there are yet no conclusive certainties about this phenomenon during the years, different factors have been proposed to be involved in the accumulation of risk factors for infertility and for male infertility. These factors could be either related to social changes as well as to lifestyle [47,48], such as smoke of tobacco [49][50][51] and marijuana [52][53][54], alcohol [55,56], medications [57] and caffeine [58], but also to the environmental pollution, such as pesticides, solvents [59,60], electromagnetic fields (EMFs) [61][62][63] and compounds able to interfere with the endocrine control of biological functions.…”

Section: Gscs Spermatozoa and Endocrine Disruptorsmentioning

confidence: 99%

Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling

Bernabò¹,

Ramal-Sanchez²,

Valbonetti³

et al. 2018

Germ Cell

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The study of germline stem cells and of germline cells has deep implications for the understanding of fertility, development and cancer. Nowadays, we are experiencing the very fascinating challenge of application of -OMICS technologies to this issue, which is opening new and unexpected horizons in virtually all the branches of biology. Here, we carried out a review of signalling systems involved in maturation of male germ cells and in the process that leads them to become fully fertile. In particular, we discuss the control mechanisms involved in capacitation and acrosome reaction that act at membrane level. Indeed, spermatozoa membranes play key roles in determining the achievement of fertility: they are the interface with the surrounding environment, they locate the signal transduction systems and they are active in recognizing and binding the oocyte. In addition, we discuss the effect of several compounds that could exert a negative effect on reproductive activity, by interfering with the endocrine axis, the so-called endocrine disruptors.

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Effects of maternal and paternal alcohol consumption on the success rates of in vitro fertilization and gamete intrafallopian transfer

Cited by 126 publications

References 24 publications

Does alcohol have any effect on male reproductive function? A review of literature

Does alcohol have any effect on male reproductive function? A review of literature

Nutrition in Human Fertility

Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling

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