Effects of magnetic field strength and b value on the sensitivity and specificity of quantitative breast diffusion-weighted MRI

Eghtedari, Mohammad; Ma, Jingfei; Fox, Patricia S.; Güvenç, İnanç; Yang, Wei Tse; Dogan, Basak E.

doi:10.21037/qims.2016.07.06

Cited by 17 publications

(12 citation statements)

References 18 publications

(16 reference statements)

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“…Thus, our study indicates that DWI acquired with regular b values (b = 1000 s/mm 2 ) can be used to calculate DWI parameters similar to those obtained with DWI acquired with higher b values in patients with thyroid nodules. This phenomenon has also been reported by Eghtedari, M. on quantitative breast DWI for breast cancer[ 23 ]. Additionally, the ADC derived from a mono-exponential model with more than two b values is theoretically good for ADC fitting.…”

Section: Discussionsupporting

confidence: 80%

Quantitative differentiation of malignant and benign thyroid nodules with multi-parameter diffusion-weighted imaging

Zhu¹,

Wang²,

Wang³

et al. 2022

WJCC

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BACKGROUND The value of conventional magnetic resonance imaging in the differential diagnosis of thyroid nodules is limited; however, the value of multi-parameter diffusion-weighted imaging (DWI) in the quantitative evaluation of thyroid nodules has not been well determined. AIM To determine the utility of multi-parametric DWI including mono-exponential, bi-exponential, stretched exponential, and kurtosis models for the differentiation of thyroid lesions. METHODS Seventy-nine patients (62 with benign and 17 with malignant nodules) underwent multi-b value diffusion-weighted imaging of the thyroid. Multiple DWI parameters were obtained for statistical analysis. RESULTS Good agreement was found for diffusion parameters of thyroid nodules. Malignant lesions displayed lower diffusion parameters including apparent diffusion coefficient (ADC), the true diffusion coefficient (D), the perfusion fraction (f), the distributed diffusion coefficient (DDC), the intravoxel water diffusion heterogeneity (α) and kurtosis model-derived ADC (Dapp), and higher apparent diffusional kurtosis (Kapp) than benign entities (all P < 0.01), except for the pseudodiffusion coefficient (D*) ( P > 0.05). The area under the ROC curve (AUC) of the ADC (0 and 1000) was not significantly different from that of the ADC (0 and 2000) , ADC (0 to 2000) , ADC (0 to 1000) , D, DDC, Dapp and Kapp (all P > 0.05), but was significantly higher than the AUC of D*, f and α (all P < 0.05) for differentiating benign from malignant lesions. CONCLUSION Multiple DWI parameters including ADC, D, f, DDC, α, Dapp and Kapp could discriminate benign and malignant thyroid nodules. The metrics including D, DDC, Dapp and Kapp provide additional information with similar diagnostic performance of ADC, combination of these metrics may contribute to differentiate benign and malignant thyroid nodules. The ADC calculated with higher b values may not lead to improved diagnostic performance.

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Section: Discussionsupporting

confidence: 80%

Quantitative differentiation of malignant and benign thyroid nodules with multi-parameter diffusion-weighted imaging

Zhu¹,

Wang²,

Wang³

et al. 2022

WJCC

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“…However, attention should be paid to diffusion-weighted imaging parameters when ADC value thresholds are used, because DWI sequence parameters, for example, repetition time, echo time, and choice of b-values can exert an impact on the calculated ADC values [36]. On the other hand, ADC values do not depend on the MR field strength under fixed imaging parameters [37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Feasibility of apparent diffusion coefficient in predicting the technical outcome of MR-guided high-intensity focused ultrasound treatment of uterine fibroids – a comparison with the Funaki classification

Sainio

Saunavaara

Komar

et al. 2021

International Journal of Hyperthermia

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“…So US can not accurately measure the volume of the lesion and not accurately observe the spatial distribution of lesional blood flow (13). Breast MRI is the most sensitive examination for breast tumor detection and it can be used to detect the spatial relationship between the lesion and the surrounding tissue, the spatial distribution of lesional blood flow as well (14)(15)(16)(17)(18). What's more, MRI can be used to assess tissue necrosis after ablation by administrating contrast agent (19,20).…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-guided percutaneous microwave ablation for benign breast lesions: evaluated by contrast-enhanced ultrasound combined with magnetic resonance imaging

Zhang¹,

Li²,

et al. 2017

J. Thorac. Dis.

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Background: Minimally invasive ablative techniques in the treatment of breast tumor has become popularly in recent years. Methods:We analyzed gray-scale and contrast-enhanced ultrasound (CEUS) features of 205 microwave ablated breast benign lesions from 182 consecutive patients, compared with magnetic resonance imaging (MRI) and histopathology findings. The follow-up was implemented at 3, 6 and 12 months after the ablation treatment.Results: Before the MWA, the mean of largest diameter and volume of the lesions were 14.41±6.54 and 3,224±961 mm 3 , respectively. However, those of the lesions respectively were 8.48±6.30 and 2,116±732 mm 3 one year after the treatment. The longest diameter and the volume of the ablative lesions were gradually decreased 3, 6 or 12 months after the MWA. 44 (/205, 21.5%) ablative lesions were disappeared one year after the MWA. One hundred and forty-two (/205, 69.3%) ablative lesions presented a hypoechoic halo surrounding it on gray-scale US after the MWA. The success rate of the MWA treatment in the benign breast lesion was 87.32% and 82.93% evaluated by CEUS and enhanced MRI, respectively. During the ablation, no patient had serious complications, such as hemorrhage, serious pain and fat necrosis, etc.Conclusions: Microwave ablation was a safe and efficient method in the treatment of the benign breast tumors. CEUS and enhanced MRI could accurately assess whether the MWA treatment is effective.

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Effects of magnetic field strength and b value on the sensitivity and specificity of quantitative breast diffusion-weighted MRI

Cited by 17 publications

References 18 publications

Quantitative differentiation of malignant and benign thyroid nodules with multi-parameter diffusion-weighted imaging

Quantitative differentiation of malignant and benign thyroid nodules with multi-parameter diffusion-weighted imaging

Feasibility of apparent diffusion coefficient in predicting the technical outcome of MR-guided high-intensity focused ultrasound treatment of uterine fibroids – a comparison with the Funaki classification

Ultrasound-guided percutaneous microwave ablation for benign breast lesions: evaluated by contrast-enhanced ultrasound combined with magnetic resonance imaging

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