Effects of magnesium acetate on the toxicity of nickelous acetate in rats

Nickel(II)-mediated oxidative DNA base damage in renal and hepatic chromatin of pregnant rats and their fetuses. Possible relevance to carcinogenesis

“…To correctly assess the results of the present study, any contribution to our results of a similar in vitro effect (i.e., any post mortem DNA base oxidation that may occur during the analytical procedure) has to be ruled out. As established before (7,8,30,31), nickel(II) concentration in the blood and kidney reaches its maximum level shortly after the injection (15-30 min) and then diminishes rapidly.…”

Nickel(II)-mediated oxidative DNA base damage in renal and hepatic chromatin of pregnant rats and their fetuses. Possible relevance to carcinogenesis

“…To correctly assess the results of the present study, any contribution to our results of a similar in vitro effect (i.e., any post mortem DNA base oxidation that may occur during the analytical procedure) has to be ruled out. As established before (7,8,30,31), nickel(II) concentration in the blood and kidney reaches its maximum level shortly after the injection (15-30 min) and then diminishes rapidly.…”

Structure and corrosion resistance of titanium oxide layers produced on NiTi alloy in low-temperature plasma

“…Nickel has also been found to interact with othe r m etals such as iron, chromium , mag nesium, manganese, zinc, and cadmium. The toxicity of nickel was mitigated by treatment with zinc (Waalkes et al 1985) and magnesium (Kasprzak et al 1986). The data suggest that magnesium, but not zinc, acted by altering the pharmacokinetics of nickel.…”

“…Coadministration of magnesium and nickel resulted in increased urinary excretion of nickel and decreased deposition of nickel in the lung, liver, and kidn ey s (Kasprzak et al 1986). Manganese dust inhibited nickel subsulfide-induced carcinogenesis following simultaneous intramuscular injection of the two compounds (Sunderman and McCully 1983).…”

“…In 2002, the United States imported 130,000 metric tons of nickel, including 121,000 metric tons of unwrought metal (97,200 metric tons of cathodes, pellets, briquets and shot; 12,300 metric tons of ferronickel; 6,970 metric tons of powder and flakes, 1,230 metric tons of metallurgical-grade oxide; 1,280 metric tons of catalysts; and 1,590 metric tons of salts), 6,080 metric tons of stainless steel scrap, and 3,030 metric tons of nickel waste and scrap (Kuck 2002). In 2002, Canada supplied the largest share of primary nickel, 59,400 metric tons (46%).…”

Nickel

“…Acute effects of water-soluble nickel compounds Nickel toxicity induced by parenteral administration of water-soluble, inorganic nickel compounds to rats induces peroxidative degradation of membrane lipids, as evidenced by: increased concentrations of thiobarbituric acid chromogens in liver, kidney, lung, spleen, and thymus; increased concentrations of conjugated dienes in hepatic microsomal lipids; and increased exhalation of ethane and ethylene (Donskoy et al 1986, Kasprzak et al 1986, Knight et al 1986.…”

Nickel(II)-mediated oxidative DNA base damage in renal and hepatic chromatin of pregnant rats and their fetuses. Possible relevance to carcinogenesis

“…To correctly assess the results of the present study, any contribution to our results of a similar in vitro effect (i.e., any post mortem DNA base oxidation that may occur during the analytical procedure) has to be ruled out. As established before (7,8,30,31), nickel(II) concentration in the blood and kidney reaches its maximum level shortly after the injection (15-30 min) and then diminishes rapidly.…”

Structure and corrosion resistance of titanium oxide layers produced on NiTi alloy in low-temperature plasma

“…Nickel has also been found to interact with othe r m etals such as iron, chromium , mag nesium, manganese, zinc, and cadmium. The toxicity of nickel was mitigated by treatment with zinc (Waalkes et al 1985) and magnesium (Kasprzak et al 1986). The data suggest that magnesium, but not zinc, acted by altering the pharmacokinetics of nickel.…”

“…Coadministration of magnesium and nickel resulted in increased urinary excretion of nickel and decreased deposition of nickel in the lung, liver, and kidn ey s (Kasprzak et al 1986). Manganese dust inhibited nickel subsulfide-induced carcinogenesis following simultaneous intramuscular injection of the two compounds (Sunderman and McCully 1983).…”

“…In 2002, the United States imported 130,000 metric tons of nickel, including 121,000 metric tons of unwrought metal (97,200 metric tons of cathodes, pellets, briquets and shot; 12,300 metric tons of ferronickel; 6,970 metric tons of powder and flakes, 1,230 metric tons of metallurgical-grade oxide; 1,280 metric tons of catalysts; and 1,590 metric tons of salts), 6,080 metric tons of stainless steel scrap, and 3,030 metric tons of nickel waste and scrap (Kuck 2002). In 2002, Canada supplied the largest share of primary nickel, 59,400 metric tons (46%).…”

Nickel

“…Acute effects of water-soluble nickel compounds Nickel toxicity induced by parenteral administration of water-soluble, inorganic nickel compounds to rats induces peroxidative degradation of membrane lipids, as evidenced by: increased concentrations of thiobarbituric acid chromogens in liver, kidney, lung, spleen, and thymus; increased concentrations of conjugated dienes in hepatic microsomal lipids; and increased exhalation of ethane and ethylene (Donskoy et al 1986, Kasprzak et al 1986, Knight et al 1986.…”

Nickel(II)-mediated oxidative DNA base damage in renal and hepatic chromatin of pregnant rats and their fetuses. Possible relevance to carcinogenesis

“…To correctly assess the results of the present study, any contribution to our results of a similar in vitro effect (i.e., any post mortem DNA base oxidation that may occur during the analytical procedure) has to be ruled out. As established before (7,8,30,31), nickel(II) concentration in the blood and kidney reaches its maximum level shortly after the injection (15-30 min) and then diminishes rapidly.…”

Structure and corrosion resistance of titanium oxide layers produced on NiTi alloy in low-temperature plasma

“…Nickel has also been found to interact with othe r m etals such as iron, chromium , mag nesium, manganese, zinc, and cadmium. The toxicity of nickel was mitigated by treatment with zinc (Waalkes et al 1985) and magnesium (Kasprzak et al 1986). The data suggest that magnesium, but not zinc, acted by altering the pharmacokinetics of nickel.…”

“…Coadministration of magnesium and nickel resulted in increased urinary excretion of nickel and decreased deposition of nickel in the lung, liver, and kidn ey s (Kasprzak et al 1986). Manganese dust inhibited nickel subsulfide-induced carcinogenesis following simultaneous intramuscular injection of the two compounds (Sunderman and McCully 1983).…”

“…In 2002, the United States imported 130,000 metric tons of nickel, including 121,000 metric tons of unwrought metal (97,200 metric tons of cathodes, pellets, briquets and shot; 12,300 metric tons of ferronickel; 6,970 metric tons of powder and flakes, 1,230 metric tons of metallurgical-grade oxide; 1,280 metric tons of catalysts; and 1,590 metric tons of salts), 6,080 metric tons of stainless steel scrap, and 3,030 metric tons of nickel waste and scrap (Kuck 2002). In 2002, Canada supplied the largest share of primary nickel, 59,400 metric tons (46%).…”

Nickel

“…Acute effects of water-soluble nickel compounds Nickel toxicity induced by parenteral administration of water-soluble, inorganic nickel compounds to rats induces peroxidative degradation of membrane lipids, as evidenced by: increased concentrations of thiobarbituric acid chromogens in liver, kidney, lung, spleen, and thymus; increased concentrations of conjugated dienes in hepatic microsomal lipids; and increased exhalation of ethane and ethylene (Donskoy et al 1986, Kasprzak et al 1986, Knight et al 1986.…”