Effects of Low-Intensity Pulsed Ultrasound on Tendon–Bone Healing in an Intra-articular Sheep Knee Model

Walsh, William R.; Stephens, Paul; Vizesi, Frank; Bruce, Warwick; Huckle, James W.; Yu, Youcheng

doi:10.1016/j.arthro.2006.09.003

Cited by 65 publications

(42 citation statements)

References 36 publications

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“…58,71,90 In an ovine model of anterior cruciate ligament reconstruction, this modality increased cellular activity at the tendonebone interface, improved local vascularity and tendonebone integration, and improved mechanical properties at the healing tendone bone interface. 107 LIPUS has demonstrated improvements in tendon-to-bone healing in various models, including a sheep infraspinatus repair model. 69,107 MMPs and their inhibitors…”

Section: Vegf and Angiogenic Factorsmentioning

confidence: 99%

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Cytokines in rotator cuff degeneration and repair

Bedi

Maak

Walsh

et al. 2012

Journal of Shoulder and Elbow Surgery

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Section: Vegf and Angiogenic Factorsmentioning

confidence: 99%

“…107 LIPUS has demonstrated improvements in tendon-to-bone healing in various models, including a sheep infraspinatus repair model. 69,107 MMPs and their inhibitors…”

Section: Vegf and Angiogenic Factorsmentioning

confidence: 99%

Cytokines in rotator cuff degeneration and repair

Bedi

Maak

Walsh

et al. 2012

Journal of Shoulder and Elbow Surgery

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“…This modality augments fracture healing and bone formation, and promotes earlier bone formation and trabecular bone expansion at the patellar tendon-patella healing junction after partial patellectomy in rabbits [45,56]. In an ovine ACL reconstruction model, this modality increased cellular activity at the tendon-bone interface, improved local vascularity and tendon-bone integration, and improved mechanical properties at the healing tendon-bone interface [73]. These studies indicate rotator cuff tendon healing may be improved by methods that increase local repair site vascularity.…”

Section: Angiogenesis In Rotator Cuff Tendon-bone Healingmentioning

confidence: 99%

Biological Augmentation of Rotator Cuff Tendon Repair

Kovacevic

Rodeo

2008

Clinical Orthopaedics &Amp; Related Research

225

181

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A histologically normal insertion site does not regenerate following rotator cuff tendon-to-bone repair, which is likely due to abnormal or insufficient gene expression and/or cell differentiation at the repair site. Techniques to manipulate the biologic events following tendon repair may improve healing. We used a sheep infraspinatus repair model to evaluate the effect of osteoinductive growth factors and BMP-12 on tendon-to-bone healing. Magnetic resonance imaging and histology showed increased formation of new bone and fibrocartilage at the healing tendon attachment site in the treated animals, and biomechanical testing showed improved load-to-failure. Other techniques with potential to augment repair site biology include use of platelets isolated from autologous blood to deliver growth factors to a tendon repair site. Modalities that improve local vascularity, such as pulsed ultrasound, have the potential to augment rotator cuff healing. Important information about the biology of tendon healing can also be gained from studies of substances that inhibit healing, such as nicotine and antiinflammatory medications. Future approaches may include the use of stem cells and transcription factors to induce formation of the native tendon-bone insertion site after rotator cuff repair surgery.

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“…Numerous methods have been reported to achieve better and quicker osteointegration of tendon graft in the bone tunnel, such as the use of bone morphogenetic protein-2, 2 transforming growth factor (TGF) b1, 3,4 TGF-b3, 4,5 stem cells, 6e8 periosteum, 9e13 calcium phosphate, 14,15 gene therapy, 16 ultrasound stimulation, 17 and hyperbaric oxygen. 18 Application of these substances into the bone tunnel aims to enhance the integration of tendon grafts at the tendonebone interface.…”

Section: Introductionmentioning

confidence: 99%