Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats

Ma, Hui; Li, Yingxin; Chen, Hongli; Kang, Meiling; Liu, Timon Cheng-Yi

doi:10.1155/2012/838496

Cited by 20 publications

(13 citation statements)

References 35 publications

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“…In a study 25 that compared the LPL irradiation at a dose of 3.6 J/cm 2 in different powers: 5 mW/cm 2 (12 min), 10 mW/ cm 2 (6 min) and 20 mW/cm 2 (3 min), applied 5 times/week for two weeks, showed that, generally the larger laser irradiation powers were more effective and significant for the quality of the cicatrization process, according to some histological criteria, such as collagen synthesis, proliferation of fibroblasts, epithelialization, quantity of polymorphonuclear and neovascularization.…”

Section: Discussionmentioning

confidence: 99%

Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

Sousa¹,

Filho

Nicolau

et al. 2015

Acta Cir. Bras.

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PURPOSE:To evaluate in a macroscopic, histological and histomorphometric manner the healing process of cutaneous wounds in mice. METHODS: RESULTS:It was observed that in the acute phase the AlGaInP Laser at 5 J/cm 2 provided a greater stimulus to healing, and both lasers were effective in the remodeling phase. CONCLUSION:The AlGaInP lasers from 5 J/cm 2 to 8 J/cm 2 showed better biomodulatory results in the acute and remodeling phases respectively, however, the HF was less effective than the laser, providing significant benefits only in the acute phase of tissue repair.

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Section: Discussionmentioning

confidence: 99%

Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

Sousa¹,

Filho

Nicolau

et al. 2015

Acta Cir. Bras.

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“…Ma et al found that LIL promoted the healing of the wound of STZ-induced diabetes of male Wistar rats before 9th day, but did not on 14th day. As a fact, even type 2 diabetes might be self-limited [66]. Lim et al found that normalisation of both beta cell function and hepatic insulin sensitivity in type 2 diabetes was achieved by dietary energy restriction alone [67].…”

Section: Successful Stress Dpbm Cannot Modulate a Successfulmentioning

confidence: 99%

Photobiomodulation on Stress

Liu

Enxiu

et al. 2012

International Journal of Photoenergy

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Photobiomodulation (PBM) is a nondamaged modulation of laser irradiation or monochromatic light (LI) on a biosystem function. It depends on whether the function is in its function-specific homeostasis (FSH). An FSH is a negative-feedback response of a biosystem to maintain the function-specific conditions inside the biosystem so that the function is perfectly performed. A function in its FSH is called a normal function. A function far from its FSH is called a dysfunctional function. The process of a function from dysfunctional to normal is called a functional normalization. For a normal function in its FSH, there are FSH-essential subfunctions (FESs), FSH-nonessential subfunctions (FNSs), and an FES/FNS-specific homeostasis (FESH/FNSH). A FSH can resist internal/external disturbances under the threshold, but can be disrupted by an FSH-specific stress (FSS). A normal/dysfunctional FSS is called a successful/chronic stress. An FESH/FNSH-specific stress was called an extraordinary/ordinary stress. A low level LI (LLL) cannot directly affect a normal function, but can modulate a chronic stress. A normal function may have a chronic ordinary stress, and an LLL may modulate the chronic ordinary stress so that it promotes the normalization of the dysfunctional FNS and then upgrades the normal function. A high level LI can modulate a normal function and may be a successful stress.

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“…For example, Ezzati et al investigated the influence of pulsed LLLT on the healing of a third-degree burn in a rat model, and it significantly increased wound closure rate [15]. Some recent studies indicated that laser effectively improved the healing of third-degree burns in diabetic rats [15,25,28]. Other studies suggest that laser irradiation accelerates wound healing of the pulp and the expression of collagens.…”

Section: Discussionmentioning

confidence: 99%

A novel method of anal fissure laser surgery: a pilot study

Esfahani¹,

Madani

Madhkhan³

2015

Lasers Med Sci

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Anal fissure is a common painful problem, affecting all age groups. Its pathophysiology is based on high sphincter pressures and reduced blood supplying and treatments which means that it generally reduces anal pressures and increases anodermal blood flow. Since each of the anal fissure's routine therapies has some limitations such as definite risk of permanent fecal incontinence and high recurrence rate, we tried to find a more effective and less invasive procedure. In this pilot study which was implemented on 25 male and female patients aged 20-75 years, diagnosed clinically with chronic anal fissure, the Carbon Dioxide Laser Fractional was used to treat patients. In order to first remove fibrotic and granulation tissues, the base and the edges of the fissure were laser beamed. Eight spots were made on the sphincter by the laser on its continuous mode; somehow, they were passed through the full thickness of sphincter without interrupting its continuance. Afterwards, the area around the fissure ulcer was irradiated by deep fractional mode of the laser to stimulate the submucosa to regenerate and rejuvenate. After going through this procedure, patients were followed up within 6 months to 1 year. Pain, bleeding, and constipation were significantly improved. None of the patients had recurrence after a 1-year follow-up, and none of them had fecal incontinence and/or inability to control the passage of gas too. This study revealed that this new laser-based surgery is a simple, safe, and effective procedure to treat the anal fissure that can be performed with local anesthesia in an outpatient clinic with minimal postoperative morbidity.

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Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats

Cited by 20 publications

References 35 publications

Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

Photobiomodulation on Stress

A novel method of anal fissure laser surgery: a pilot study

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