volume 93, issue 0, P2-P-222 2020
DOI: 10.1254/jpssuppl.93.0_2-p-222
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Abstract: Acetaminophen (APAP) is commonly used as an antipyretic agent, although this side effect, i.e., hepatic injury, is so severe. It has been reported that lotus shows the anti-inflammatory and anti-cytoprotective actions. This study evaluates effects of lotus extract on APAP-induced hepatic inflammation. Seven-week-old male ICR mice were orally administered lotus extract or saline (10mL/kg) once a day for a week. Twenty-four hours after the last pretreatment, the mice were intraperitoneally injected with 200 mg/k…

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