2021
DOI: 10.21203/rs.3.rs-564229/v1
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Abstract: Objective: The present study aimed to explore the possible levetiracetam mechanisms of action in the adenosine signaling systems using the PTZ-induced acute seizure and the PTZ-induced kindling model of epileptogenesis.Method: In acute model, male mice received caffeine (non-specific adenosine receptor antagonist), or dipropylcyclopentylxanthine (DPCPX) (specific A1 receptor antagonist) prior to levetiracetam. After 30 minutes, a convulsant dose of PTZ (100 mg/kg) was administered to determine whether caffeine… Show more

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“…GIRK activation may reduce neuronal excitability by hyperpolarizing resting membrane potential. Levetiracetam, which is widely used in the treatment of epilepsy, increased Kir3.2 expression in a PTZ‐induced chronic epilepsy model in mice (Jamal et al, 2021). Elevated Kir3.2 currents may mediate the anticonvulsant effects of levetiracetam in epileptic patients.…”
Section: Insights Into the Role Of Kir3x In Epilepsymentioning
confidence: 99%
“…GIRK activation may reduce neuronal excitability by hyperpolarizing resting membrane potential. Levetiracetam, which is widely used in the treatment of epilepsy, increased Kir3.2 expression in a PTZ‐induced chronic epilepsy model in mice (Jamal et al, 2021). Elevated Kir3.2 currents may mediate the anticonvulsant effects of levetiracetam in epileptic patients.…”
Section: Insights Into the Role Of Kir3x In Epilepsymentioning
confidence: 99%