Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation

Abstract

The study of hematopoiesis has been greatly facilitated by transplantation of blood cell populations into recipient animals. Efficient engraftment of donor cells generally requires ablation of the host hematopoietic system. The zebrafish has recently emerged as a developmental and genetic system to study hematopoiesis. To enable the study of hematopoietic stem cell ( IntroductionThe study of the biologic effects of ␥ irradiation began over a century ago, 1 but it was not until deployment of the atomic bomb i…