Effects of lead on lactating rats and their sucklings

Tooth lead levels as an estimate of lead body burden in rats following pre- and neonatal exposure

“…They also found that lead levels in rat incisors were of similar magnitude to the lead concentrations in the alveolar bone. In the present study, kidney and liver samples showed higher lead levels than brain, similar to the results of Roels et al, 23 who exposed lactating rats to different concentrations of lead in drinking water and measured the levels of lead in the liver, kidney, brain and heart of their sucklings. Maternal blood-lead levels were highest in Group 5 followed by Groups 3, 4 and 2 in decreasing order of lead concentration.…”

“…21 Previous studies that have used similar or higher doses did not report any observable signs of acute toxicity. 22,23 Tissue collection…”

Tooth lead levels as an estimate of lead body burden in rats following pre- and neonatal exposure

“…They also found that lead levels in rat incisors were of similar magnitude to the lead concentrations in the alveolar bone. In the present study, kidney and liver samples showed higher lead levels than brain, similar to the results of Roels et al, 23 who exposed lactating rats to different concentrations of lead in drinking water and measured the levels of lead in the liver, kidney, brain and heart of their sucklings. Maternal blood-lead levels were highest in Group 5 followed by Groups 3, 4 and 2 in decreasing order of lead concentration.…”

“…21 Previous studies that have used similar or higher doses did not report any observable signs of acute toxicity. 22,23 Tissue collection…”

Effects of Perinatal Treatment with Lead and Disulfiram on ALAD Activity in Blood, Liver and Kidney and Urinary ALA Excretion in Rats

“…The ALAD activity in control rats was about 4 times higher in the offspring than in the dams. Similar observations have been reported for women and infants (Kuhnert et al 1977) and in rats (Roels et al 1977;Hayashi 1983). Kuhnert (1977) suggested that the greater cell volume of the foetal erythrocytes allows a correspondingly greater amount of the enzyme ALAD.…”

“…In Table 2. Similar observations have been reported for women and infants (Kuhnert et al 1977) and in rats (Roels et al 1977;Hayashi 1983). Determinations were made at the end of exposure, when the rats were 4 weeks of age, and 2 weeks later.…”

Dose Dependent Transfer of 203 Lead to Milk and Tissue Uptake in Suckling Offspring Studied in Rats and Mice

“…Transport of lead from mothers to suckling offspring has been reported in human (Rabinowitz et al 1985) and experimental animals (Kostial 1974;Bornschein et al 1977;Roels et al 1977). In our laboratory, a high transfer of lead into milk was demonstrated in rats, as well as a high uptake of lead in the tissues of the suckling pups (Palminger & Oskarsson 1991).…”

Tooth lead levels as an estimate of lead body burden in rats following pre- and neonatal exposure

“…They also found that lead levels in rat incisors were of similar magnitude to the lead concentrations in the alveolar bone. In the present study, kidney and liver samples showed higher lead levels than brain, similar to the results of Roels et al, 23 who exposed lactating rats to different concentrations of lead in drinking water and measured the levels of lead in the liver, kidney, brain and heart of their sucklings. Maternal blood-lead levels were highest in Group 5 followed by Groups 3, 4 and 2 in decreasing order of lead concentration.…”

“…21 Previous studies that have used similar or higher doses did not report any observable signs of acute toxicity. 22,23 Tissue collection…”

Effects of Perinatal Treatment with Lead and Disulfiram on ALAD Activity in Blood, Liver and Kidney and Urinary ALA Excretion in Rats

“…The ALAD activity in control rats was about 4 times higher in the offspring than in the dams. Similar observations have been reported for women and infants (Kuhnert et al 1977) and in rats (Roels et al 1977;Hayashi 1983). Kuhnert (1977) suggested that the greater cell volume of the foetal erythrocytes allows a correspondingly greater amount of the enzyme ALAD.…”

“…In Table 2. Similar observations have been reported for women and infants (Kuhnert et al 1977) and in rats (Roels et al 1977;Hayashi 1983). Determinations were made at the end of exposure, when the rats were 4 weeks of age, and 2 weeks later.…”

Dose Dependent Transfer of 203 Lead to Milk and Tissue Uptake in Suckling Offspring Studied in Rats and Mice

“…Transport of lead from mothers to suckling offspring has been reported in human (Rabinowitz et al 1985) and experimental animals (Kostial 1974;Bornschein et al 1977;Roels et al 1977). In our laboratory, a high transfer of lead into milk was demonstrated in rats, as well as a high uptake of lead in the tissues of the suckling pups (Palminger & Oskarsson 1991).…”

Tooth lead levels as an estimate of lead body burden in rats following pre- and neonatal exposure

“…They also found that lead levels in rat incisors were of similar magnitude to the lead concentrations in the alveolar bone. In the present study, kidney and liver samples showed higher lead levels than brain, similar to the results of Roels et al, 23 who exposed lactating rats to different concentrations of lead in drinking water and measured the levels of lead in the liver, kidney, brain and heart of their sucklings. Maternal blood-lead levels were highest in Group 5 followed by Groups 3, 4 and 2 in decreasing order of lead concentration.…”

“…21 Previous studies that have used similar or higher doses did not report any observable signs of acute toxicity. 22,23 Tissue collection…”

Effects of Perinatal Treatment with Lead and Disulfiram on ALAD Activity in Blood, Liver and Kidney and Urinary ALA Excretion in Rats

“…The ALAD activity in control rats was about 4 times higher in the offspring than in the dams. Similar observations have been reported for women and infants (Kuhnert et al 1977) and in rats (Roels et al 1977;Hayashi 1983). Kuhnert (1977) suggested that the greater cell volume of the foetal erythrocytes allows a correspondingly greater amount of the enzyme ALAD.…”

“…In Table 2. Similar observations have been reported for women and infants (Kuhnert et al 1977) and in rats (Roels et al 1977;Hayashi 1983). Determinations were made at the end of exposure, when the rats were 4 weeks of age, and 2 weeks later.…”

Dose Dependent Transfer of 203 Lead to Milk and Tissue Uptake in Suckling Offspring Studied in Rats and Mice

“…Transport of lead from mothers to suckling offspring has been reported in human (Rabinowitz et al 1985) and experimental animals (Kostial 1974;Bornschein et al 1977;Roels et al 1977). In our laboratory, a high transfer of lead into milk was demonstrated in rats, as well as a high uptake of lead in the tissues of the suckling pups (Palminger & Oskarsson 1991).…”