Effects of Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) on Weight Loss and Biomarker Parameters in Morbidly Obese Patients: A 12-Month Follow-Up

Toolabi, Karamollah; Arefanian, Saeed; Golzarand, Mahdieh; Arefanian, Hossein

doi:10.1007/s11695-011-0525-8

Cited by 23 publications

(11 citation statements)

References 44 publications

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“…This is concerning, as higher ALP concentrations are seen in Alzheimer's disease patients and correlated with the neurotoxic effects of tau protein (Vardy et al, 2012; Diaz-Hernandez et al, 2010). Fortunately, ALP concentrations have been shown to improve following bariatric surgery (Toolabi et al, 2011). Yet, the literature is not entirely consistent on this matter, as extant evidence also shows no changes in ALP concentrations after bariatric surgery (De Abreu et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Past work shows that bariatric surgery can improve cystatin C and ALP concentrations (Toolabi et al, 2011; Fenske et al, 2013), though no study has examined whether this pattern of metabolic improvements is also associated with post-bariatric surgery cognitive benefits. The current study examined whether changes in cystatin C and ALP correspond to improved cognitive function following bariatric surgery.…”

Section: Introductionmentioning

confidence: 99%

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The effects of cystatin C and alkaline phosphatase changes on cognitive function 12-months after bariatric surgery

Alosco

Spitznagel

Strain

et al. 2014

Journal of the Neurological Sciences

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Background The mechanisms for improved cognitive function post-bariatric surgery are not well understood. Markers of kidney and liver function (i.e., cystatin C and alkaline phosphatase (ALP)) are elevated in obese individuals and associated with poor neurocognitive outcomes in other samples. Bariatric surgery can improve cystatin C and ALP levels, but no study has examined whether such changes correspond to post-operative cognitive benefits. Methods 78 bariatric surgery patients completed a computerized cognitive test battery prior to and 12-months after surgery. All participants underwent an eight-hour fasting blood draw to quantify cystatin C and ALP concentrations. Results Cognitive function improved after surgery. Cystatin C levels decreased at the 12-month follow-up; however, no changes were found in ALP concentrations. At baseline, higher cystatin C levels predicted worse attention/executive function, but no such effects emerged for ALP. Regression analyses controlling for possible medical and demographic confounds and baseline factors revealed that decreased ALP levels following surgery predicted better attention/executive function and memory abilities. Post-surgery changes in cystatin C did not correspond to cognitive improvements. Conclusions Decreased ALP levels predicted better cognition following bariatric surgery, suggesting improved liver function as a possible mechanism of post-operative cognitive benefits. Future studies with neuroimaging and longer follow-up periods are needed to determine whether bariatric surgery can decrease risk for adverse brain changes and dementia in severely obese persons via improved metabolic function.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effects of cystatin C and alkaline phosphatase changes on cognitive function 12-months after bariatric surgery

Alosco

Spitznagel

Strain

et al. 2014

Journal of the Neurological Sciences

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“…The current findings, in the context of past work showing that liver function often improves following bariatric surgery (19) and preoperative ALP is linked to better postoperative cognition (9), suggest a need for future work to determine the extent to which liver function directly affects cognitive abilities. Limitations of the current work include the crosssectional design and single, early postoperative time point, as well as lack of a control group comparison.…”

Section: Discussionmentioning

confidence: 63%

Liver Fibrosis Predicts Cognitive Function Following Bariatric Surgery: A Preliminary Investigation

Spitznagel

Gunstad

Manderino

et al. 2015

Obesity

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Objective: Obesity is a well-established risk factor for poor neurological outcomes, and bariatric surgery has been shown to improve many aspects of cognitive function. Factors underlying improved cognition following surgery are not yet fully established. A recent study of bariatric surgery patients demonstrated lower preoperative alkaline phosphatase concentrations were linked to greater postoperative cognitive improvement, but this link has not been examined via liver biopsy. The current study examined postoperative cognitive function in individuals with and without fibrosis at the time of bariatric surgery. It expected that those with fibrosis would demonstrate poorer postoperative cognition. Methods: Thirty-six bariatric surgery patients underwent routine liver biopsy at the time of surgery and completed cognitive testing 1 month postoperatively. Results: Bariatric surgery patients with fibrosis demonstrated poorer performance on a task of executive function (maze errors, P 5 0.01) and verbal memory (recognition memory, P 5 0.01). Conclusions: Bariatric surgery patients with fibrosis demonstrated poorer cognition following surgery, providing further evidence for the connection between liver disease and cognitive function. Future work examining mechanisms underlying bariatric postoperative cognitive changes should include examination of broader metabolic functions, particularly liver function.

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“…Toolabi et al showed significant improvement in all components of lipid profile one year after surgery (20). Golpaie et al reported significant reduction in LDL and triglycerides levels six weeks post-surgery (21).…”

Section: Discussionmentioning

confidence: 99%

Serum Lipid Profile Changes After Bariatric Surgery

Khalaj

Yazdi

Sabet

et al. 2019

Thrita

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Background: Obesity is accompanied by a number of comorbidities that gravely lower patients' quality of life; one such comorbidity is serum lipid abnormalities. Studies have shown that weight loss decreases serum total cholesterol and low-density lipoprotein (LDL) cholesterol and increases high-density lipoprotein (HDL) cholesterol. Bariatric surgery is one of the most recent ways to treat obesity and manage weight loss in overweight patients whose options for weight loss are limited. Objectives: The aim of this study was to assess the effect of bariatric surgery on lipid profile of surgical candidates during the three months of post-operative care. Methods: This prospective study was performed among 36 obese candidates of bariatric surgery at Mostafa Khomeini Hospital in Tehran, Iran from April to September of 2012. Body mass index (BMI), serum cholesterol, triglyceride, HDL and LDL levels were measured before and three months following the surgical intervention. Results: The mean age of the participants was 35.39 ± 10.32 years. Mean body mass index (BMI) of the patients before surgery was 46.74 ± 6.71 kg/m 2 , which was lowered to 38.24 ± 5.31 kg/m 2 after the intervention. Assessments showed a statistically significant increase in the serum level of HDL and a statistically significant decrease in the serum level of triglycerides, but no significant change in the serum level of cholesterol or LDL was noted. Moreover, results showed a positive correlation between serum LDL variations and changes in BMI. Conclusions: Our findings showed that bariatric surgery improves weight loss and can help with managing or treating co-morbid illnesses through reducing triglyceride level and increasing HDL level, both of which improve patients' long-term cardiac, hepatic and endocrine health status.

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Effects of Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) on Weight Loss and Biomarker Parameters in Morbidly Obese Patients: A 12-Month Follow-Up

Cited by 23 publications

References 44 publications

The effects of cystatin C and alkaline phosphatase changes on cognitive function 12-months after bariatric surgery

The effects of cystatin C and alkaline phosphatase changes on cognitive function 12-months after bariatric surgery

Liver Fibrosis Predicts Cognitive Function Following Bariatric Surgery: A Preliminary Investigation

Serum Lipid Profile Changes After Bariatric Surgery

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