Effects of Lactuca sativa extract on exploratory behavior pattern, locomotor activity and anxiety in mice

Harsha, S.N.

doi:10.1016/s2222-1808(12)60206-0

Cited by 11 publications

(5 citation statements)

References 20 publications

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“…2) It has traditionally been used in the treatment of insomnia, anxiety, neurosis, dry coughs, and stomach problems. 1,3) In particular, the leaves of this plant have been known to promote anticonvulsant and sedative-hypnotic effects and the seeds have been studied in analgesic and anti-inflammatory activity in rats. 4,5) Sleep is a crucial physiological state to maintain normal body function.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (<i>Lactuca sativa</i>) in a Rodent Model

Kim

Suh

Hyun-Min

et al. 2019

Biological & Pharmaceutical Bulletin

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This study was conducted to investigate the effects of the extracts of green romaine lettuce (GRE) on sleep enhancement. GRE contains 1071.7 and 199.2 µg/g of extracts of lactucin and lactucopicrin, respectively, known as sleep enhancement substances. When 100 mg/kg of GRE was administered orally, sleep latency and duration time were significantly increased compared to controls (p < 0.05). Rapid eye movement (REM) sleep decreased with 100 mg/kg of GRE administration and non-REM (NREM) sleep also increased. There was no significant difference between REM and NREM among the oral GRE administration groups receiving 100, 120, and 160 mg/kg GRE. In the caffeine-induced insomnia model, total sleep time was significantly increased by 100 mg/kg GRE administration compared to the caffeine-treated group (p < 0.05). In addition, GRE inhibited the binding of [ 3 H]-flumazenil in a concentration-dependent manner, and affinity of both lactucin and lactucopicrin to gamma-aminobutyric acid (GABA) A-benzodiazepine (BDZ) receptor was 80.7% and 55.9%, respectively. Finally, in the pentobarbital-induced sleep mouse model, the sleep enhancement effect of GRE was inhibited by flumazenil, an antagonist of BDZ. Thus, these results demonstrate that GRE acts via a GABAergic mechanism to promote sleep in a rodent model.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (<i>Lactuca sativa</i>) in a Rodent Model

Kim

Suh

Hyun-Min

et al. 2019

Biological & Pharmaceutical Bulletin

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“…The authors attributed these effects to simple phenols and saponins compounds demonstrated in several plant extracts. The anxiolytic properties of the hydro-alcoholic extract of the Lactuca sativa leaves in mice were reported by Harsha and Anilakumar [21]. Lactuca sativa acts as an antioxidant in preventing either cancer- [22] and D-galactose-induced oxidative stress [23] in mice.…”

Section: Introductionmentioning

confidence: 99%

Lactuca capensis reverses memory deficits in Aβ1‐42‐induced an animal model of Alzheimer's disease

Postu

Noumedem

Cioancă

et al. 2017

J Cellular Molecular Medi

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We investigated the neuropharmacological effects of the methanolic extract from Lactuca capensis Thunb. leaves (100 and 200 mg/kg) for 21 days on memory impairment in an Alzheimer's disease (AD) rat model produced by direct intraventricular delivery of amyloid‐β1‐42 (Aβ1‐42). Behavioural assays such as Y‐maze and radial arm maze test were used for assessing memory performance. Aβ1‐42 decreased cognitive performance in the behavioural tests which were ameliorated by pre‐treatment with the methanolic extract. Acetylcholinesterase activity and oxidant–antioxidant balance in the rat hippocampus were abnormally altered by Aβ1‐42 treatment while these deficits were recovered by pre‐treatment with the methanolic extract. In addition, rats were given Aβ1‐42 exhibited in the hippocampus decreased brain‐derived neurotrophic factor (BDNF) mRNA copy number and increased IL‐1β mRNA copy number which was reversed by the methanolic extract administration. These findings suggest that the methanolic extract could be a potent neuropharmacological agent against dementia via modulating cholinergic activity, increasing of BDNF levels and promoting antioxidant action in the rat hippocampus.

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“…Lactuca sativa was fed to animals for two different treatment duration (15 days and 30 days) and subjected for a variety of behaviour parameters like elevated plus maze, elevated T maze, open field test, marble burying test, rat exposure test, novel object recognition test, hyponeophagia. The plant extract treated group found to improve exploratory behaviour, lacomotory activity in mice 48,49 .…”

Section: Anti-anxiety Propertymentioning

confidence: 96%

Lettuce: a promising leafy vegetable with functional properties

Harsha¹,

Mallesha²,

Sharma³

2017

Def. Life. Sc. Jl.

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Lactuca sativa (lettuce) belongs to Asteraceae family important leafy vegetable known for its medicinal properties. The lettuce is a food that should not lack in our meals, we should keep in mind that its low fat and carbohydrate contents and its high contents of water, it provides caloric power of only 13 Kcal /100 gm are very appropriate for weight loss diets. It is rich in minerals, especially potassium that is very necessary to maintain appropriate levels of liquids in the body, together with calcium and phosphorus makes it especially for the correct well being of the bones. It contains selenium, an antioxidant that has a medicinal property in prevention of certain type of cancers, colon, prostrate and lungs. It contains many necessary amino acids for the formation of the proteins, alanine, and necessary for the construction of muscular and nervous tissues, glycine for the correct operation of immunological system. The most of therapeutic properties of this plant is due to sesquiterpene lactones-lactucin, lactucopicrin the most bioactive compound of Lactuca sativa. This review mainly focuses on the pharmacological action of the Lettuce and active constituents for the wide spectrum biological properties, such as anti-oxidant, anti-inflammatory, anti-microbial, analgesic, neuroprotective and sedative properties, etc. Since Lettuce has medicinal therapeutic potential its usage in dietary supplementation can be exploited. Lettuce has also acquired a folk reputation. More clinical studies are needed to further asses the efficiency and safety in therapeutic application.

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Effects of Lactuca sativa extract on exploratory behavior pattern, locomotor activity and anxiety in mice

Cited by 11 publications

References 20 publications

Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (<i>Lactuca sativa</i>) in a Rodent Model

Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (<i>Lactuca sativa</i>) in a Rodent Model

Lactuca capensis reverses memory deficits in Aβ1‐42‐induced an animal model of Alzheimer's disease

Lettuce: a promising leafy vegetable with functional properties

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