Effects of L-carnitine supplementation on nutritional, immunological, and cardiac parameters in hemodialysis patients: a pilot study

Sada, Haruki; Kato, Akihiko; Sumimoto, Ryo; Ohmori, Harunori; Ohdan, Hideki

doi:10.1186/s41100-015-0004-0

Cited by 4 publications

(6 citation statements)

References 30 publications

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“…In addition, carnitine supplementation also affects other nutritional factors. Previous studies reported that L ‐carnitine supplementation improved the plasma lipid profile, cardiac function, anemia, and responses to erythropoietin [9,10,13–16]. In the present study, the following results were obtained.…”

Section: Discussionsupporting

confidence: 76%

“…Hence, the ratio of acyl to free carnitine is increased in hemodialysis patients as compared to healthy controls. It has been shown in several reports [9][10][11][12], as well as in our study, that although total, free, and acyl carnitine change simultaneously, the ratio of acyl to free carnitine does not decrease at all or decreases only slightly in hemodialysis patients. The main reason for carnitine deficiency in dialysis patients is free carnitine disposal during hemodialysis.…”

Section: Discussionsupporting

confidence: 72%

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Effectiveness of monitoring free carnitine levels for L‐carnitine supplementation in hemodialysis patients to maintain carnitine sufficiency and nutritional factors

Kumagai

Hosohata

Furumachi³

2021

Ther Apher Dial

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We investigated the effectiveness of monitoring serum carnitine levels in hemodialysis patients receiving L-carnitine supplementation. One-hundred forty-five hemodialysis patients were divided into three groups. Group 1 consisted of patients (n = 30) who had been receiving supplementation before this study and then discontinued at the beginning. The remaining patients were divided into Group 2 (n = 13) and Group 3 (n = 102) based on their baseline free carnitine (FC) level, <20 or ≥ 20 μmol/L. Group 2 was started on supplementation, and Groups 1 and 3 were observed without any intervention for the first 6 months. FC was measured every 6 months in all three groups up to 18 months. All patients in whom FC was less than 20 μmol/L at 6 and 12 months were prescribed supplementation. After the first 6 months, the mean ± SD of FC changed from 262.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 72%

Effectiveness of monitoring free carnitine levels for L‐carnitine supplementation in hemodialysis patients to maintain carnitine sufficiency and nutritional factors

Kumagai

Hosohata

Furumachi³

2021

Ther Apher Dial

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“…The results of this study showed that carnitine injection along with endurance training could reduce the myocardial tissue damage caused by boldenone. Previous studies have demonstrated the protective effects on the heart due to supplementation with L-carnitine (39)(40)(41)(42). In this regard, Sada et al (2015) showed that L-carnitine supplementation significantly increased left ventricular function (42).…”

Section: Discussionmentioning

confidence: 97%

“…Previous studies have demonstrated the protective effects on the heart due to supplementation with L-carnitine (39)(40)(41)(42). In this regard, Sada et al (2015) showed that L-carnitine supplementation significantly increased left ventricular function (42). Koeth et al found a significant association between plasma L-carnitine levels and risk of coronary artery disease, peripheral vascular disease, and heart risk factors in heart disease (43).…”

Section: Discussionmentioning

confidence: 99%

Structural changes of cardiac tissue in response to L-carnitine supplementation during endurance training in Wistar male rats toxicated by steroid anabolic hormone

Karimabadi¹,

Daloii

Abdi³

et al. 2017

hmj

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Introduction: The aim of this study was to investigate the structural changes of cardiac tissue in response to L-carnitine supplementation and endurance training in Wistar male rats toxicated by steroid anabolic hormone. Methods: 36 male Wistar rats aged 8-12 weeks (weight 195±7.94g) were randomly divided into six groups: Control, Non-treated, Boldenone (5 mg/kg), L-carnitine (100 mg per kg), Endurance Training-L-carnitine and Sham group. Injection was conducted deep in the hamstring once a week on an appointed day. The endurance training Protocol with moderate intensity (50-55% maximal oxygen consumption) was performed for six weeks and five times a week. After anesthesia, autopsy was performed and the cardiac tissue was isolated. Results: The results showed that boldenone causes damage to the heart tissue muscle and heart muscle cells. Also, boldenone caused mild necrosis and congestion in the heart tissue. However, the results showed that L-carnitine supplementation with endurance training can decrease to normal levels and damage the heart tissue muscle and heart muscle cells. Conclusion: According to the findings, it seems that boldenone causes some structural changes in the heart tissue, and possibly endurance training with L-carnitine supplementation can reduce these changes.

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“…The canonical function of L-carnitine is to regulate the transportation of medium-chain and long-chain fatty acids across the inner mitochondrial membrane for β-oxidation (Sada, Kato, Sumimoto, Ohmori, & Ohdan, 2015). Recent studies have shown that L-carnitine also participates in the regulation of reproduction.…”

Section: Introductionmentioning

confidence: 99%

L‐carnitine increases cell proliferation and amino acid transporter expression via the activation of insulin‐like growth factor I signaling pathway in rat trophoblast cells

Zhang

Heng

et al. 2020

Food Science & Nutrition

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Early embryo implantation and development is primarily determined by the homeostasis between cellular apoptosis and proliferation as well as placental nutrient transporters. Recent studies showed that L‐carnitine enhances female reproductive performance. However, the potential function of L‐carnitine on placenta is largely unknown. In our study, primary rat trophoblast cells were separated and cultured for 12 hr in medium containing various concentrations of L‐carnitine (0, 1, 10, and 50 mM). Placenta trophoblast cells treated with 50 mM L‐carnitine increased the proportion of cells in S phase of the cell cycle ( p < .05). In addition, live cell percentage was increased when treated with either 10 mM or 50 mM L‐carnitine, which was accompanied with decreased necrotic cells, late apoptotic cells, and early apoptotic cells ( p < .05). Compared with the control treatment, the mRNA expression of insulin‐like growth factor I (IGF‐1) and insulin‐like growth factor I receptor (IGF‐1R) was higher in rat placenta trophoblasts treated with either 10 mM or 50 mM L‐carnitine ( p < .05). Similarly, sodium‐dependent neutral amino acid transporter (SNAT)‐1 and SNAT2 were up‐regulated in both mRNA and protein levels when trophoblast cells were treated with 50 mM L‐carnitine ( p < .05). Inhibiting downstream targets (Akt or ERK signaling pathways) of IGF‐1 signaling pathway partially blocked the effect the L‐carnitine‐induced increase in protein abundances of SNAT1 and SNAT2. Collectively, our data showed protective role of L‐carnitine on placenta trophoblast cells through the involvement of IGF‐1 signaling pathway.

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Effects of L-carnitine supplementation on nutritional, immunological, and cardiac parameters in hemodialysis patients: a pilot study

Cited by 4 publications

References 30 publications

Effectiveness of monitoring free carnitine levels for L‐carnitine supplementation in hemodialysis patients to maintain carnitine sufficiency and nutritional factors

Effectiveness of monitoring free carnitine levels for L‐carnitine supplementation in hemodialysis patients to maintain carnitine sufficiency and nutritional factors

Structural changes of cardiac tissue in response to L-carnitine supplementation during endurance training in Wistar male rats toxicated by steroid anabolic hormone

L‐carnitine increases cell proliferation and amino acid transporter expression via the activation of insulin‐like growth factor I signaling pathway in rat trophoblast cells

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