Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice

Ábrahám, Szabolcs; Hermesz, Edit; Szabó, Andrea; Ferencz, Ágnes; Jancsó, Zsanett; Duda, E.; Ábrahám, Magdolna; Lázár, György

doi:10.1016/j.lfs.2011.10.021

Cited by 10 publications

(8 citation statements)

References 52 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HO-1 and MT-1 genes are rapidly upregulated by proinflammatory cytokines or oxidative stress, as a protection mechanism against cellular stress in the liver (45). HO-1 is widely used as a sensitive stress response marker in oxidative damage induced by xenobiotics (46).…”

Section: Discussionmentioning

confidence: 99%

Role of oxidative stress in liver toxicity induced by nickel oxide nanoparticles in rats

Liu

Wang

et al. 2017

Mol Med Report

View full text Add to dashboard Cite

The aim of the present study was to explore the role of oxidative stress in liver toxicity induced by nickel oxide nanoparticles (nano‑NiO) in rats. Male Wistar rats received saline (control), nano‑NiO [0.015, 0.06 or 0.24 mg/kg body weight (b.w.)] or micro‑NiO (0.24 mg/kg b.w.) by intratracheal instilling twice a week for 6 weeks. Liver tissues were then collected and examined for biomarkers of nitrative and oxidative stress, as well as mRNA expression of heme oxygenase (HO)‑1 and metallothionein (MT)‑1. The results demonstrated that the NiO exposure groups had increased liver wet weight and coefficient to body weight, as well as liver pathological changes, evidenced as cellular edema, hepatic sinus disappeara-nce and binucleated hepatocytes. The activities of total nitric oxide synthase and inducible nitric oxide synthase, and the nitric oxide content, were increased in the 0.24 mg/kg nano‑NiO group compared with the control group. The MT‑1 mRNA expression levels were downregulated, while HO‑1 mRNA was upregulated in the 0.24 mg/kg nano‑NiO exposure group compared with the control group. In addition, abnormal changes of hydroxyl radical, lipid peroxidation, catalase, glutathione peroxidase, total superoxide dismutase and total antioxidative capacity were observed in the liver tissues of the 0.24 mg/kg nano‑NiO exposure group, compared with the control group. The present results therefore indicated that nano‑NiO‑induced liver toxicity may be associated with nitrative and oxidative stress in rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of oxidative stress in liver toxicity induced by nickel oxide nanoparticles in rats

Liu

Wang

et al. 2017

Mol Med Report

View full text Add to dashboard Cite

show abstract

“…SOD and catalase activities were slightly increased in BDL groups, and both were significantly augmented by WAC administration. This phenomenon might be a compensative response to the BDL-induced oxidative stress and the depletion of the GSH defense system (Abraham et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Artemisia capillaris extract protects against bile duct ligation-induced liver fibrosis in rats

Han

Kim

Choi

et al. 2013

Experimental and Toxicologic Pathology

View full text Add to dashboard Cite

“…In MOJ, the lack of bile salt, impaired intestinal mucosal barrier, and disrupted intestinal immune barrier function result in absorption of endotoxin into the liver through the portal vein (6,27,28). In addition, the activity of liver Kupffer cells (KCs) is inhibited, and their functions in phagocytosis and cell killing are impaired, meaning that KCs cannot effectively remove endotoxin (29,30). Consequently, endotoxemia occurs, and the invading endotoxin activates KCs to induce their secretion of various inflammatory factors, such as TNF-α, IL-6, and Lp-PLA2, that mediate inflammatory reactions and cause body damage (31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

Changes in preoperative and postoperative lipoprotein-associated phospholipase A2 activity in patients with malignant obstructive jaundice

Ying

Feng

2020

Ann Palliat Med

View full text Add to dashboard Cite

Background: Malignant obstructive jaundice (MOJ) leads to hyperbilirubinemia and systemic pathophysiological changes. The main clinical treatments for MOJ include radical pancreatoduodenectomy, palliative surgical treatment, and minimally invasive treatment, which can relieve biliary obstruction, drain bile, reduce jaundice, and improve liver function. In rat models, hepatic exposure to endotoxin resulted in rapid increases in biliary and plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels, and our previous study revealed that Lp-PLA2 activity was strongly associated with liver damage. The present study aimed to clarify the serum Lp-PLA2 activity changes and evaluate the associations between Lp-PLA2 activity and laboratory parameters in MOJ patients preoperatively and postoperatively.Methods: Twenty-one patients with MOJ were enrolled in this prospective study. Lp-PLA2 activity and other laboratory parameters were analyzed using a Hitachi 7600 automatic biochemical analyzer. Spearman correlation coefficients, percent differences, and dynamic difference plots were used to evaluate the changes in preoperative and postoperative Lp-PLA2 activity and the associations of Lp-PLA2 activity with other laboratory parameters.

show abstract

Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice

Cited by 10 publications

References 52 publications

Role of oxidative stress in liver toxicity induced by nickel oxide nanoparticles in rats

Role of oxidative stress in liver toxicity induced by nickel oxide nanoparticles in rats

Artemisia capillaris extract protects against bile duct ligation-induced liver fibrosis in rats

Changes in preoperative and postoperative lipoprotein-associated phospholipase A2 activity in patients with malignant obstructive jaundice

Contact Info

Product

Resources

About