2011
DOI: 10.1111/j.1540-8167.2011.02173.x
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Abstract: Ivabradine decreased the I(f)s and Ca(2+)(i) transient in the PV cardiomyocytes, which may contribute to its inhibitory effects on the PV spontaneous activity.

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Cited by 37 publications
(31 citation statements)
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“…The pulmonary venous myocardium, which is an important source of AF initiation and maintenance,6 demonstrates an I f current which is affected by ivabradine 7. This raises the possibility that ivabradine treatment may affect AF risk.…”
Section: Introductionmentioning
confidence: 99%
“…The pulmonary venous myocardium, which is an important source of AF initiation and maintenance,6 demonstrates an I f current which is affected by ivabradine 7. This raises the possibility that ivabradine treatment may affect AF risk.…”
Section: Introductionmentioning
confidence: 99%
“…This suggests a positive correlation between the I f channel protein expression and the beating rate [5]. Blocking I f by ivabradine has been found to decrease spontaneous activity of PV cells by 85% [10]. I NCX has also been shown to contribute to cell automaticity as blocking I NCX decreases the firing rates of PV cells [6].…”
Section: Introductionmentioning
confidence: 94%
“…Whether it is appropriate to extrapolate from data in a rabbit to man,1 particularly when the evidence is currently only at concentrations many times higher than found with licensed dosing, is unclear. Another mechanism of action may be that bradycardia in itself may encourage the initiation of AF, although the evidence for this is also weak.…”
Section: What Might the Mechanism Of Increased Af Risk Be?mentioning
confidence: 99%
“…There is some evidence of more widespread I f channel expression in disease states, and in other species, including in pulmonary vein myocytes in the rabbit 1. Ruairidh and colleagues2 raise the possibility that ivabradine may affect the electrical properties of pulmonary venous myocardium, increasing the risk of AF.…”
mentioning
confidence: 99%